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Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia

Increased ASM mass, primarily due to ASM hyperplasia, has been recognized as a hallmark of airway remodeling in asthma. Increased ASM mass is the major contributor to the airway narrowing, thus worsening the bronchoconstriction in response to stimuli. Inflammatory mediators and growth factors releas...

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Main Authors: Yap, Hui Min, Israf Ali, Daud Ahmad, Harith, Hanis Hazeera, Tham, Chau Ling, Sulaiman, Mohd Roslan
Format: Article
Language:English
Published: Frontiers Research Foundation 2019
Online Access:http://psasir.upm.edu.my/id/eprint/81053/1/ASM.pdf
http://psasir.upm.edu.my/id/eprint/81053/
https://www.frontiersin.org/articles/10.3389/fphar.2019.01148/full
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spelling my.upm.eprints.810532020-10-14T19:02:16Z http://psasir.upm.edu.my/id/eprint/81053/ Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia Yap, Hui Min Israf Ali, Daud Ahmad Harith, Hanis Hazeera Tham, Chau Ling Sulaiman, Mohd Roslan Increased ASM mass, primarily due to ASM hyperplasia, has been recognized as a hallmark of airway remodeling in asthma. Increased ASM mass is the major contributor to the airway narrowing, thus worsening the bronchoconstriction in response to stimuli. Inflammatory mediators and growth factors released during inflammation induce increased ASM mass surrounding airway wall via increased ASM proliferation, diminished ASM apoptosis and increased ASM migration. Several major pathways, such as MAPKs, PI3K/AKT, JAK2/STAT3 and Rho kinase, have been reported to regulate these cellular activities in ASM and were reported to be interrelated at certain points. This article aims to provide an overview of the signaling pathways/molecules involved in ASM hyperplasia as well as the mapping of the interplay/crosstalk between these major pathways in mediating ASM hyperplasia. A more comprehensive understanding of the complexity of cellular signaling in ASM cells will enable more specific and safer drug development in the control of asthma. Frontiers Research Foundation 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81053/1/ASM.pdf Yap, Hui Min and Israf Ali, Daud Ahmad and Harith, Hanis Hazeera and Tham, Chau Ling and Sulaiman, Mohd Roslan (2019) Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia. Frontiers in Pharmacology, 10. art. no. 1148. pp. 1-16. ISSN 1663-9812 https://www.frontiersin.org/articles/10.3389/fphar.2019.01148/full 10.3389/fphar.2019.01148
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Increased ASM mass, primarily due to ASM hyperplasia, has been recognized as a hallmark of airway remodeling in asthma. Increased ASM mass is the major contributor to the airway narrowing, thus worsening the bronchoconstriction in response to stimuli. Inflammatory mediators and growth factors released during inflammation induce increased ASM mass surrounding airway wall via increased ASM proliferation, diminished ASM apoptosis and increased ASM migration. Several major pathways, such as MAPKs, PI3K/AKT, JAK2/STAT3 and Rho kinase, have been reported to regulate these cellular activities in ASM and were reported to be interrelated at certain points. This article aims to provide an overview of the signaling pathways/molecules involved in ASM hyperplasia as well as the mapping of the interplay/crosstalk between these major pathways in mediating ASM hyperplasia. A more comprehensive understanding of the complexity of cellular signaling in ASM cells will enable more specific and safer drug development in the control of asthma.
format Article
author Yap, Hui Min
Israf Ali, Daud Ahmad
Harith, Hanis Hazeera
Tham, Chau Ling
Sulaiman, Mohd Roslan
spellingShingle Yap, Hui Min
Israf Ali, Daud Ahmad
Harith, Hanis Hazeera
Tham, Chau Ling
Sulaiman, Mohd Roslan
Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia
author_facet Yap, Hui Min
Israf Ali, Daud Ahmad
Harith, Hanis Hazeera
Tham, Chau Ling
Sulaiman, Mohd Roslan
author_sort Yap, Hui Min
title Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia
title_short Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia
title_full Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia
title_fullStr Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia
title_full_unstemmed Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia
title_sort crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia
publisher Frontiers Research Foundation
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/81053/1/ASM.pdf
http://psasir.upm.edu.my/id/eprint/81053/
https://www.frontiersin.org/articles/10.3389/fphar.2019.01148/full
_version_ 1681490843963228160
score 13.211869

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