Cover Image

Isobolographic analysis of the hypnotic interaction between propofol and thiopental

Introduction: Giving two intravenous anaesthetic agents simultaneously generally results in an additive effect. The aim of this study was to investigate the interaction between propofol and thiopental when given to patients who have had sedative premedication. Methods: Fifty patients were admitted...

Full description

Saved in:
Bibliographic Details
Main Authors: Wong, Wai Hong, Lim, Thiam Aun, Lim, K. Y.
Format: Article
Language:English
Published: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2010
Online Access:http://psasir.upm.edu.my/id/eprint/8092/1/Isobolographic83-89%28edSP%29.pdf
http://psasir.upm.edu.my/id/eprint/8092/
http://www.medic.upm.edu.my/dokumen/FKUSK1_MJMHS_2010V06N1_OP05.pdf
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.8092
record_format eprints
spelling my.upm.eprints.80922015-09-08T08:39:00Z http://psasir.upm.edu.my/id/eprint/8092/ Isobolographic analysis of the hypnotic interaction between propofol and thiopental Wong, Wai Hong Lim, Thiam Aun Lim, K. Y. Introduction: Giving two intravenous anaesthetic agents simultaneously generally results in an additive effect. The aim of this study was to investigate the interaction between propofol and thiopental when given to patients who have had sedative premedication. Methods: Fifty patients were admitted into the study. All patients received oral midazolam 3.75 mg and intravenous fentanyl 100 mg before induction of anaesthesia. Twenty patients received an infusion of either propofol or thiopental while 30 patients received an infusion of an admixture of both drugs. Isobolographic analysis was used to determine the interaction between the two drugs. Results: The interaction between propofol and thiopental was additive. The average dose at loss of the eyelash reflex for propofol and thiopental was 0.71 mg kg-1 and 1.54 mg kg-1 respectively. Premedication decreased the induction dose by 38.2%. Conclusion: Propofol and thiopental interact in an additive fashion when given at induction of anaesthesia. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2010-01 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/8092/1/Isobolographic83-89%28edSP%29.pdf Wong, Wai Hong and Lim, Thiam Aun and Lim, K. Y. (2010) Isobolographic analysis of the hypnotic interaction between propofol and thiopental. Malaysian Journal of Medicine and Health Sciences, 6 (1). pp. 83-89. ISSN 1675-8544 http://www.medic.upm.edu.my/dokumen/FKUSK1_MJMHS_2010V06N1_OP05.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Introduction: Giving two intravenous anaesthetic agents simultaneously generally results in an additive effect. The aim of this study was to investigate the interaction between propofol and thiopental when given to patients who have had sedative premedication. Methods: Fifty patients were admitted into the study. All patients received oral midazolam 3.75 mg and intravenous fentanyl 100 mg before induction of anaesthesia. Twenty patients received an infusion of either propofol or thiopental while 30 patients received an infusion of an admixture of both drugs. Isobolographic analysis was used to determine the interaction between the two drugs. Results: The interaction between propofol and thiopental was additive. The average dose at loss of the eyelash reflex for propofol and thiopental was 0.71 mg kg-1 and 1.54 mg kg-1 respectively. Premedication decreased the induction dose by 38.2%. Conclusion: Propofol and thiopental interact in an additive fashion when given at induction of anaesthesia.
format Article
author Wong, Wai Hong
Lim, Thiam Aun
Lim, K. Y.
spellingShingle Wong, Wai Hong
Lim, Thiam Aun
Lim, K. Y.
Isobolographic analysis of the hypnotic interaction between propofol and thiopental
author_facet Wong, Wai Hong
Lim, Thiam Aun
Lim, K. Y.
author_sort Wong, Wai Hong
title Isobolographic analysis of the hypnotic interaction between propofol and thiopental
title_short Isobolographic analysis of the hypnotic interaction between propofol and thiopental
title_full Isobolographic analysis of the hypnotic interaction between propofol and thiopental
title_fullStr Isobolographic analysis of the hypnotic interaction between propofol and thiopental
title_full_unstemmed Isobolographic analysis of the hypnotic interaction between propofol and thiopental
title_sort isobolographic analysis of the hypnotic interaction between propofol and thiopental
publisher Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
publishDate 2010
url http://psasir.upm.edu.my/id/eprint/8092/1/Isobolographic83-89%28edSP%29.pdf
http://psasir.upm.edu.my/id/eprint/8092/
http://www.medic.upm.edu.my/dokumen/FKUSK1_MJMHS_2010V06N1_OP05.pdf
_version_ 1643823916235358208
score 13.211869

Similar Items