Cover Image

Characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system

The drug release properties of magnesium orotate (MgOr) encapsulated in the chitosan (CS) cavity and the complexation behavior between MgOr and CS were investigated. The MgOr‐loaded CS nanoparticles (MgOrCSNPs) were characterized by differential scanning calorimetry, Fourier transform infrared spect...

Full description

Saved in:
Bibliographic Details
Main Authors: Abdelkader, Hassani, Hussain, Siti Aslina, Abdullah, Norhafizah, Kamarudin, Suryani, Rosli, Rozita
Format: Article
Language:English
Published: WILEY-VCH Verlag 2019
Online Access:http://psasir.upm.edu.my/id/eprint/80914/1/OROTATE.pdf
http://psasir.upm.edu.my/id/eprint/80914/
https://onlinelibrary.wiley.com/doi/full/10.1002/ceat.201800478
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.80914
record_format eprints
spelling my.upm.eprints.809142020-10-14T21:22:47Z http://psasir.upm.edu.my/id/eprint/80914/ Characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system Abdelkader, Hassani Hussain, Siti Aslina Abdullah, Norhafizah Kamarudin, Suryani Rosli, Rozita The drug release properties of magnesium orotate (MgOr) encapsulated in the chitosan (CS) cavity and the complexation behavior between MgOr and CS were investigated. The MgOr‐loaded CS nanoparticles (MgOrCSNPs) were characterized by differential scanning calorimetry, Fourier transform infrared spectroscopy, X‐ray diffraction, transmission electron microscopy, and scanning electron microscopy with energy‐dispersive X‐ray spectroscopy. MgOr was successfully encapsulated into the CS cavity. Results with 3‐(4,5‐dimethylthiazol‐2‐yl)2,5‐diphenyl tetrazolium bromide indicated that MgOrCSNPs retained their cytotoxic activity against the liver cancer cell line (HepG2) and breast cancer cell line (MCF‐7), and low toxicity against the human cell line (3T3) and human retinal epithelial cell line (ARPE‐19). WILEY-VCH Verlag 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80914/1/OROTATE.pdf Abdelkader, Hassani and Hussain, Siti Aslina and Abdullah, Norhafizah and Kamarudin, Suryani and Rosli, Rozita (2019) Characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system. Chemical Engineering & Technology, 42 (9). pp. 1816-1824. ISSN 0930-7516; ESSN: 1521-4125 https://onlinelibrary.wiley.com/doi/full/10.1002/ceat.201800478 10.1002/ceat.201800478
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The drug release properties of magnesium orotate (MgOr) encapsulated in the chitosan (CS) cavity and the complexation behavior between MgOr and CS were investigated. The MgOr‐loaded CS nanoparticles (MgOrCSNPs) were characterized by differential scanning calorimetry, Fourier transform infrared spectroscopy, X‐ray diffraction, transmission electron microscopy, and scanning electron microscopy with energy‐dispersive X‐ray spectroscopy. MgOr was successfully encapsulated into the CS cavity. Results with 3‐(4,5‐dimethylthiazol‐2‐yl)2,5‐diphenyl tetrazolium bromide indicated that MgOrCSNPs retained their cytotoxic activity against the liver cancer cell line (HepG2) and breast cancer cell line (MCF‐7), and low toxicity against the human cell line (3T3) and human retinal epithelial cell line (ARPE‐19).
format Article
author Abdelkader, Hassani
Hussain, Siti Aslina
Abdullah, Norhafizah
Kamarudin, Suryani
Rosli, Rozita
spellingShingle Abdelkader, Hassani
Hussain, Siti Aslina
Abdullah, Norhafizah
Kamarudin, Suryani
Rosli, Rozita
Characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system
author_facet Abdelkader, Hassani
Hussain, Siti Aslina
Abdullah, Norhafizah
Kamarudin, Suryani
Rosli, Rozita
author_sort Abdelkader, Hassani
title Characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system
title_short Characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system
title_full Characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system
title_fullStr Characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system
title_full_unstemmed Characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system
title_sort characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system
publisher WILEY-VCH Verlag
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/80914/1/OROTATE.pdf
http://psasir.upm.edu.my/id/eprint/80914/
https://onlinelibrary.wiley.com/doi/full/10.1002/ceat.201800478
_version_ 1681490830241562624
score 13.211869

Similar Items