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Antifungal activity of titanium dioxide nanoparticles against Candida albicans

The unregulated release of titanium dioxide nanoparticles into the environment has raised concern, in particular due to the impact of the nanoparticles on indigenous micro-biome in our ecosystem. This paper reports a study on antifungal activity of titanium dioxide nanoparticles on a healthy growing...

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Main Authors: Ahmad, Nurul Shahidah, Abdullah, Norhafizah, Md Yasin, Faizah
Format: Article
Language:English
Published: North Carolina State University 2019
Online Access:http://psasir.upm.edu.my/id/eprint/80672/1/FUNGAL.pdf
http://psasir.upm.edu.my/id/eprint/80672/
https://bioresources.cnr.ncsu.edu/resources/antifungal-activity-of-titanium-dioxide-nanoparticles-against-candida-albicans/
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spelling my.upm.eprints.806722020-11-12T00:43:54Z http://psasir.upm.edu.my/id/eprint/80672/ Antifungal activity of titanium dioxide nanoparticles against Candida albicans Ahmad, Nurul Shahidah Abdullah, Norhafizah Md Yasin, Faizah The unregulated release of titanium dioxide nanoparticles into the environment has raised concern, in particular due to the impact of the nanoparticles on indigenous micro-biome in our ecosystem. This paper reports a study on antifungal activity of titanium dioxide nanoparticles on a healthy growing fungi species, Candida albicans, a known opportunistic pathogen. A quantification of the total cell death was performed using a direct staining method, Trypan blue exclusion assay. Exposure to nanoparticles not only altered the growth rate, but also affected the onset and length of Candida albicans growth phases. The log and the onset of the death phase were shortened and accelerated, respectively. Up to 65% of the Candida albicans were killed after exposure to 100 μg/mL of the anatase titanium dioxide nanoparticles, while only 33% were killed with rutile. A higher dosage and incubation time of the nanoparticles increased their toxicity. Cells suffered from morphological changes upon the nanoparticle exposure, which correlates well with the results showing an altered growth phase culture. North Carolina State University 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80672/1/FUNGAL.pdf Ahmad, Nurul Shahidah and Abdullah, Norhafizah and Md Yasin, Faizah (2019) Antifungal activity of titanium dioxide nanoparticles against Candida albicans. BioResources, 14 (4). pp. 8866-8878. ISSN 1930-2126 https://bioresources.cnr.ncsu.edu/resources/antifungal-activity-of-titanium-dioxide-nanoparticles-against-candida-albicans/
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The unregulated release of titanium dioxide nanoparticles into the environment has raised concern, in particular due to the impact of the nanoparticles on indigenous micro-biome in our ecosystem. This paper reports a study on antifungal activity of titanium dioxide nanoparticles on a healthy growing fungi species, Candida albicans, a known opportunistic pathogen. A quantification of the total cell death was performed using a direct staining method, Trypan blue exclusion assay. Exposure to nanoparticles not only altered the growth rate, but also affected the onset and length of Candida albicans growth phases. The log and the onset of the death phase were shortened and accelerated, respectively. Up to 65% of the Candida albicans were killed after exposure to 100 μg/mL of the anatase titanium dioxide nanoparticles, while only 33% were killed with rutile. A higher dosage and incubation time of the nanoparticles increased their toxicity. Cells suffered from morphological changes upon the nanoparticle exposure, which correlates well with the results showing an altered growth phase culture.
format Article
author Ahmad, Nurul Shahidah
Abdullah, Norhafizah
Md Yasin, Faizah
spellingShingle Ahmad, Nurul Shahidah
Abdullah, Norhafizah
Md Yasin, Faizah
Antifungal activity of titanium dioxide nanoparticles against Candida albicans
author_facet Ahmad, Nurul Shahidah
Abdullah, Norhafizah
Md Yasin, Faizah
author_sort Ahmad, Nurul Shahidah
title Antifungal activity of titanium dioxide nanoparticles against Candida albicans
title_short Antifungal activity of titanium dioxide nanoparticles against Candida albicans
title_full Antifungal activity of titanium dioxide nanoparticles against Candida albicans
title_fullStr Antifungal activity of titanium dioxide nanoparticles against Candida albicans
title_full_unstemmed Antifungal activity of titanium dioxide nanoparticles against Candida albicans
title_sort antifungal activity of titanium dioxide nanoparticles against candida albicans
publisher North Carolina State University
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/80672/1/FUNGAL.pdf
http://psasir.upm.edu.my/id/eprint/80672/
https://bioresources.cnr.ncsu.edu/resources/antifungal-activity-of-titanium-dioxide-nanoparticles-against-candida-albicans/
_version_ 1684654755991781376
score 13.211869

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