Cover Image

In vitro antiatherothrombotic effects of extracts from Berberis vulgaris L., Teucrium polium L., and Orthosiphon stamineus benth

Coronary artery disease is the leading cause of mortality and morbidity worldwide. The pathogenesis is mainly due to atherosclerosis, plaque rupture, and platelet thrombus formation. The main risk factors for coronary artery disease include obesity, hypercholesterolemia, smoking, diabetes, and high...

Full description

Saved in:
Bibliographic Details
Main Authors: Mohd Nor, Nurul Huda, Othman, Fauziah, Mohd Tohid, Eusni Rahayu, Md Noor, Sabariah, Razali, Rosniza, Ahmad Hassali, Hazlina, Hassan, Hadijah
Format: Article
Language:English
Published: Hindawi Limited 2019
Online Access:http://psasir.upm.edu.my/id/eprint/80215/1/In%20vitro%20antiatherothrombotic%20effects%20of%20extracts%20from%20Berberis%20vulgaris%20L.%2C%20Teucrium%20polium%20L.%2C%20and%20Orthosiphon%20stamineus%20benth.pdf
http://psasir.upm.edu.my/id/eprint/80215/
https://www.hindawi.com/journals/ecam/2019/3245836/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.80215
record_format eprints
spelling my.upm.eprints.802152020-10-02T07:28:35Z http://psasir.upm.edu.my/id/eprint/80215/ In vitro antiatherothrombotic effects of extracts from Berberis vulgaris L., Teucrium polium L., and Orthosiphon stamineus benth Mohd Nor, Nurul Huda Othman, Fauziah Mohd Tohid, Eusni Rahayu Md Noor, Sabariah Razali, Rosniza Ahmad Hassali, Hazlina Hassan, Hadijah Coronary artery disease is the leading cause of mortality and morbidity worldwide. The pathogenesis is mainly due to atherosclerosis, plaque rupture, and platelet thrombus formation. The main risk factors for coronary artery disease include obesity, hypercholesterolemia, smoking, diabetes, and high blood pressure. As a part of disease management, treatment options using anticoagulant and antiplatelet drugs can be applied with addition to lipid-lowering medication. However, medicinal plants comprising antiatherothrombotic effects can be used as options to combat the disease rather than drug therapies with lesser adverse effects. Therefore, the haematological effect of Berberis vulgaris L., Teucrium polium L., and Orthosiphon stamineus Benth extracts was studied using in vitro model to prevent and to treat coronary atherothrombotic disease. The aqueous, methanol, and polysaccharide extracts of B. vulgaris, T. polium, and O. stamineus, respectively, were studied for their anticoagulant and antiplatelet effect on human whole blood. Extracts were subjected to the prothrombin time (PT) and activated partial thromboplastin time (APTT) test for anticoagulant activity. The antiplatelet activity was investigated using an electrical impedance method. B. vulgaris aqueous extract (BVAE), B. vulgaris polysaccharide extract (BVPE), T. polium aqueous extract (TPAE), and T. polium polysaccharide extract (TPPE) significantly prolonged the coagulation time in a concentration-dependent manner (p<0.05). The administration of BVAE demonstrated the most effective antiplatelet activity against platelet aggregation caused by arachidonic acid (AA) and collagen. These antiplatelet activities may correspond to the presence of higher total phenolic compound, which thus inhibit the platelet aggregation activity. In conclusion, these findings provide strong evidence on the antiatherothrombotic effect of BVAE and TPAE. Hindawi Limited 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80215/1/In%20vitro%20antiatherothrombotic%20effects%20of%20extracts%20from%20Berberis%20vulgaris%20L.%2C%20Teucrium%20polium%20L.%2C%20and%20Orthosiphon%20stamineus%20benth.pdf Mohd Nor, Nurul Huda and Othman, Fauziah and Mohd Tohid, Eusni Rahayu and Md Noor, Sabariah and Razali, Rosniza and Ahmad Hassali, Hazlina and Hassan, Hadijah (2019) In vitro antiatherothrombotic effects of extracts from Berberis vulgaris L., Teucrium polium L., and Orthosiphon stamineus benth. Evidence-Based Complementary and Alternative Medicine. art. no. 245836. pp. 1-10. ISSN 1741-427X; ESSN: 1741-4288 https://www.hindawi.com/journals/ecam/2019/3245836/ 10.1155/2019/3245836
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Coronary artery disease is the leading cause of mortality and morbidity worldwide. The pathogenesis is mainly due to atherosclerosis, plaque rupture, and platelet thrombus formation. The main risk factors for coronary artery disease include obesity, hypercholesterolemia, smoking, diabetes, and high blood pressure. As a part of disease management, treatment options using anticoagulant and antiplatelet drugs can be applied with addition to lipid-lowering medication. However, medicinal plants comprising antiatherothrombotic effects can be used as options to combat the disease rather than drug therapies with lesser adverse effects. Therefore, the haematological effect of Berberis vulgaris L., Teucrium polium L., and Orthosiphon stamineus Benth extracts was studied using in vitro model to prevent and to treat coronary atherothrombotic disease. The aqueous, methanol, and polysaccharide extracts of B. vulgaris, T. polium, and O. stamineus, respectively, were studied for their anticoagulant and antiplatelet effect on human whole blood. Extracts were subjected to the prothrombin time (PT) and activated partial thromboplastin time (APTT) test for anticoagulant activity. The antiplatelet activity was investigated using an electrical impedance method. B. vulgaris aqueous extract (BVAE), B. vulgaris polysaccharide extract (BVPE), T. polium aqueous extract (TPAE), and T. polium polysaccharide extract (TPPE) significantly prolonged the coagulation time in a concentration-dependent manner (p<0.05). The administration of BVAE demonstrated the most effective antiplatelet activity against platelet aggregation caused by arachidonic acid (AA) and collagen. These antiplatelet activities may correspond to the presence of higher total phenolic compound, which thus inhibit the platelet aggregation activity. In conclusion, these findings provide strong evidence on the antiatherothrombotic effect of BVAE and TPAE.
format Article
author Mohd Nor, Nurul Huda
Othman, Fauziah
Mohd Tohid, Eusni Rahayu
Md Noor, Sabariah
Razali, Rosniza
Ahmad Hassali, Hazlina
Hassan, Hadijah
spellingShingle Mohd Nor, Nurul Huda
Othman, Fauziah
Mohd Tohid, Eusni Rahayu
Md Noor, Sabariah
Razali, Rosniza
Ahmad Hassali, Hazlina
Hassan, Hadijah
In vitro antiatherothrombotic effects of extracts from Berberis vulgaris L., Teucrium polium L., and Orthosiphon stamineus benth
author_facet Mohd Nor, Nurul Huda
Othman, Fauziah
Mohd Tohid, Eusni Rahayu
Md Noor, Sabariah
Razali, Rosniza
Ahmad Hassali, Hazlina
Hassan, Hadijah
author_sort Mohd Nor, Nurul Huda
title In vitro antiatherothrombotic effects of extracts from Berberis vulgaris L., Teucrium polium L., and Orthosiphon stamineus benth
title_short In vitro antiatherothrombotic effects of extracts from Berberis vulgaris L., Teucrium polium L., and Orthosiphon stamineus benth
title_full In vitro antiatherothrombotic effects of extracts from Berberis vulgaris L., Teucrium polium L., and Orthosiphon stamineus benth
title_fullStr In vitro antiatherothrombotic effects of extracts from Berberis vulgaris L., Teucrium polium L., and Orthosiphon stamineus benth
title_full_unstemmed In vitro antiatherothrombotic effects of extracts from Berberis vulgaris L., Teucrium polium L., and Orthosiphon stamineus benth
title_sort in vitro antiatherothrombotic effects of extracts from berberis vulgaris l., teucrium polium l., and orthosiphon stamineus benth
publisher Hindawi Limited
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/80215/1/In%20vitro%20antiatherothrombotic%20effects%20of%20extracts%20from%20Berberis%20vulgaris%20L.%2C%20Teucrium%20polium%20L.%2C%20and%20Orthosiphon%20stamineus%20benth.pdf
http://psasir.upm.edu.my/id/eprint/80215/
https://www.hindawi.com/journals/ecam/2019/3245836/
_version_ 1680322372367810560
score 13.211869

Similar Items