Evaluation of in vitro release kinetics and mechanisms of curcumin-loaded cockle shell-derived calcium carbonate nanoparticles

Introduction: Curcumin has remarkable pharmacological activities but remains clinically constrained due to its poor bioavailability as a result of insolubility. This has necessitated the search for natural inorganic materials for curcumin delivery. Cockleshells are external hard materials of marine...

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Main Authors: Mailafiya, Maryam Muhammad, Abubakar, Kabeer, Danmaigoro, Abubakar, Chiroma, Samaila Musa, Abdul Rahim, Ezamin, Mohd Moklas, Mohamad Aris, Abu Bakar @ Zakaria, Md Zuki
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Published: BioMedPress 2019
Online Access:http://psasir.upm.edu.my/id/eprint/79756/
http://www.bmrat.org/index.php/BMRAT/article/view/580
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spelling my.upm.eprints.797562022-11-01T06:52:48Z http://psasir.upm.edu.my/id/eprint/79756/ Evaluation of in vitro release kinetics and mechanisms of curcumin-loaded cockle shell-derived calcium carbonate nanoparticles Mailafiya, Maryam Muhammad Abubakar, Kabeer Danmaigoro, Abubakar Chiroma, Samaila Musa Abdul Rahim, Ezamin Mohd Moklas, Mohamad Aris Abu Bakar @ Zakaria, Md Zuki Introduction: Curcumin has remarkable pharmacological activities but remains clinically constrained due to its poor bioavailability as a result of insolubility. This has necessitated the search for natural inorganic materials for curcumin delivery. Cockleshells are external hard materials of marine animals often treated as unwanted wastes, which are excellent sources of calcium carbonate. This study aimed to synthesize cockle shell-derived calcium carbonate (aragonite) nanoparticles (CSCaCO3NP) for delivery of curcumin and to evaluate its kinetic release in vitro. Methods: CSCaCO3NP was synthesized and conjugated with curcumin (Cur-CSCaCO3NP) using a simple top down approach and characterized for its physicochemical properties as a potential curcumin carrier. The in vitro release profile was assessed using the dialysis bag membrane method. The release data were fitted to Korsmeyer-Peppas, Zero order, and Higuchi models to evaluate the mechanism(s) of the release pattern. Results: A spherical shaped CSCaCO3NP with a surface area of 14.48+/-0.1 m2/g, with mean diameter size of 21.38+/-2.7 nm and zeta potential of -18.7 mV, was synthesized and found to have high loading content and encapsulation efficiency. The FT-IR and XRD revealed fewer observable changes on the peaks after conjugation. The profile of the in vitro kinetic release demonstrated a sustained release, and which was best fitted to the Higuchi equation model. Conclusion: The results of this study showed the capacity of the synthesized CSCaCO3NP to encapsulate curcumin efficiently with a stable release in vitro. This provides insight into and rationale for the potential of CSCaCO3NP for curcumin delivery. Therefore, CSCaCO3NP holds great prospects in the preclinical framework for enhancing curcumin efficacy in oral therapeutic applications. BioMedPress 2019 Article PeerReviewed Mailafiya, Maryam Muhammad and Abubakar, Kabeer and Danmaigoro, Abubakar and Chiroma, Samaila Musa and Abdul Rahim, Ezamin and Mohd Moklas, Mohamad Aris and Abu Bakar @ Zakaria, Md Zuki (2019) Evaluation of in vitro release kinetics and mechanisms of curcumin-loaded cockle shell-derived calcium carbonate nanoparticles. Biomedical Research and Therapy, 6 (12). pp. 3518-3540. ISSN 2198-4093 http://www.bmrat.org/index.php/BMRAT/article/view/580 10.15419/bmrat.v6i12.580
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Introduction: Curcumin has remarkable pharmacological activities but remains clinically constrained due to its poor bioavailability as a result of insolubility. This has necessitated the search for natural inorganic materials for curcumin delivery. Cockleshells are external hard materials of marine animals often treated as unwanted wastes, which are excellent sources of calcium carbonate. This study aimed to synthesize cockle shell-derived calcium carbonate (aragonite) nanoparticles (CSCaCO3NP) for delivery of curcumin and to evaluate its kinetic release in vitro. Methods: CSCaCO3NP was synthesized and conjugated with curcumin (Cur-CSCaCO3NP) using a simple top down approach and characterized for its physicochemical properties as a potential curcumin carrier. The in vitro release profile was assessed using the dialysis bag membrane method. The release data were fitted to Korsmeyer-Peppas, Zero order, and Higuchi models to evaluate the mechanism(s) of the release pattern. Results: A spherical shaped CSCaCO3NP with a surface area of 14.48+/-0.1 m2/g, with mean diameter size of 21.38+/-2.7 nm and zeta potential of -18.7 mV, was synthesized and found to have high loading content and encapsulation efficiency. The FT-IR and XRD revealed fewer observable changes on the peaks after conjugation. The profile of the in vitro kinetic release demonstrated a sustained release, and which was best fitted to the Higuchi equation model. Conclusion: The results of this study showed the capacity of the synthesized CSCaCO3NP to encapsulate curcumin efficiently with a stable release in vitro. This provides insight into and rationale for the potential of CSCaCO3NP for curcumin delivery. Therefore, CSCaCO3NP holds great prospects in the preclinical framework for enhancing curcumin efficacy in oral therapeutic applications.
format Article
author Mailafiya, Maryam Muhammad
Abubakar, Kabeer
Danmaigoro, Abubakar
Chiroma, Samaila Musa
Abdul Rahim, Ezamin
Mohd Moklas, Mohamad Aris
Abu Bakar @ Zakaria, Md Zuki
spellingShingle Mailafiya, Maryam Muhammad
Abubakar, Kabeer
Danmaigoro, Abubakar
Chiroma, Samaila Musa
Abdul Rahim, Ezamin
Mohd Moklas, Mohamad Aris
Abu Bakar @ Zakaria, Md Zuki
Evaluation of in vitro release kinetics and mechanisms of curcumin-loaded cockle shell-derived calcium carbonate nanoparticles
author_facet Mailafiya, Maryam Muhammad
Abubakar, Kabeer
Danmaigoro, Abubakar
Chiroma, Samaila Musa
Abdul Rahim, Ezamin
Mohd Moklas, Mohamad Aris
Abu Bakar @ Zakaria, Md Zuki
author_sort Mailafiya, Maryam Muhammad
title Evaluation of in vitro release kinetics and mechanisms of curcumin-loaded cockle shell-derived calcium carbonate nanoparticles
title_short Evaluation of in vitro release kinetics and mechanisms of curcumin-loaded cockle shell-derived calcium carbonate nanoparticles
title_full Evaluation of in vitro release kinetics and mechanisms of curcumin-loaded cockle shell-derived calcium carbonate nanoparticles
title_fullStr Evaluation of in vitro release kinetics and mechanisms of curcumin-loaded cockle shell-derived calcium carbonate nanoparticles
title_full_unstemmed Evaluation of in vitro release kinetics and mechanisms of curcumin-loaded cockle shell-derived calcium carbonate nanoparticles
title_sort evaluation of in vitro release kinetics and mechanisms of curcumin-loaded cockle shell-derived calcium carbonate nanoparticles
publisher BioMedPress
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/79756/
http://www.bmrat.org/index.php/BMRAT/article/view/580
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