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Effect of the applied pressure on the essential characteristics of sodium starch glycolate tablets

Immediate onset of action in a lot of cases is extensively used than ordinary therapy, however; produce tablets with acceptable features as tensile strength, suitable with acceptable industrial limits, reduced ordered unit segregation tendency, and rapidly or appropriate disintegration time, is a cl...

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Main Authors: Mousa Al-Ibraheemi, Zahraa A., Mahdi, Ali Basim, Taip, Farah Saleena, Anuar, Mohd Shamsul
Format: Article
Language:English
Published: IOP Publishing 2019
Online Access:http://psasir.upm.edu.my/id/eprint/79555/1/Effect%20of%20the%20applied%20pressure%20on%20the%20essential%20characteristics%20of%20sodium%20starch%20glycolate%20tablets.pdf
http://psasir.upm.edu.my/id/eprint/79555/
https://iopscience.iop.org/article/10.1088/1742-6596/1279/1/012028/meta
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spelling my.upm.eprints.795552021-06-28T09:54:45Z http://psasir.upm.edu.my/id/eprint/79555/ Effect of the applied pressure on the essential characteristics of sodium starch glycolate tablets Mousa Al-Ibraheemi, Zahraa A. Mahdi, Ali Basim Taip, Farah Saleena Anuar, Mohd Shamsul Immediate onset of action in a lot of cases is extensively used than ordinary therapy, however; produce tablets with acceptable features as tensile strength, suitable with acceptable industrial limits, reduced ordered unit segregation tendency, and rapidly or appropriate disintegration time, is a classic problem. Use disintegrant is considered one of corner stone to achieve pharmaceutical tablets that meet requirements of recommended tablet formulation in the markets. Sodium Starch Glycolate as an elastic material (super disintegrant) is the component of compacted tablets by direct compression in current work. Uniaxial compaction process was implemented by utilizing a universal testing machine. The tablets were compacted under applied load ranging from 75 to 375 MPa. A 13 mm diameter cylindrical die was used to characterize the compression behaviour of the 1.0 ± 0.01 g of material. Number of the evidences from this study is, the tabletted powder characteristics and the volume-pressure measurements relationship were investigated. The recommended tablet formulations were evaluated by using elastic relaxation, indirect tensile strength, friability, and disintegration tests. Applying load higher than 150 Mpa produces compacts with a longer disintegration time, low elastic relaxation, in addition to tensile strength and friability percentage identical to recommended tablets formulation in the markets. IOP Publishing 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/79555/1/Effect%20of%20the%20applied%20pressure%20on%20the%20essential%20characteristics%20of%20sodium%20starch%20glycolate%20tablets.pdf Mousa Al-Ibraheemi, Zahraa A. and Mahdi, Ali Basim and Taip, Farah Saleena and Anuar, Mohd Shamsul (2019) Effect of the applied pressure on the essential characteristics of sodium starch glycolate tablets. Journal of Physics: Conference Series, 1279. pp. 1-11. ISSN 1742-6588; ESSN: 1742-6596 https://iopscience.iop.org/article/10.1088/1742-6596/1279/1/012028/meta 10.1088/1742-6596/1279/1/012028
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Immediate onset of action in a lot of cases is extensively used than ordinary therapy, however; produce tablets with acceptable features as tensile strength, suitable with acceptable industrial limits, reduced ordered unit segregation tendency, and rapidly or appropriate disintegration time, is a classic problem. Use disintegrant is considered one of corner stone to achieve pharmaceutical tablets that meet requirements of recommended tablet formulation in the markets. Sodium Starch Glycolate as an elastic material (super disintegrant) is the component of compacted tablets by direct compression in current work. Uniaxial compaction process was implemented by utilizing a universal testing machine. The tablets were compacted under applied load ranging from 75 to 375 MPa. A 13 mm diameter cylindrical die was used to characterize the compression behaviour of the 1.0 ± 0.01 g of material. Number of the evidences from this study is, the tabletted powder characteristics and the volume-pressure measurements relationship were investigated. The recommended tablet formulations were evaluated by using elastic relaxation, indirect tensile strength, friability, and disintegration tests. Applying load higher than 150 Mpa produces compacts with a longer disintegration time, low elastic relaxation, in addition to tensile strength and friability percentage identical to recommended tablets formulation in the markets.
format Article
author Mousa Al-Ibraheemi, Zahraa A.
Mahdi, Ali Basim
Taip, Farah Saleena
Anuar, Mohd Shamsul
spellingShingle Mousa Al-Ibraheemi, Zahraa A.
Mahdi, Ali Basim
Taip, Farah Saleena
Anuar, Mohd Shamsul
Effect of the applied pressure on the essential characteristics of sodium starch glycolate tablets
author_facet Mousa Al-Ibraheemi, Zahraa A.
Mahdi, Ali Basim
Taip, Farah Saleena
Anuar, Mohd Shamsul
author_sort Mousa Al-Ibraheemi, Zahraa A.
title Effect of the applied pressure on the essential characteristics of sodium starch glycolate tablets
title_short Effect of the applied pressure on the essential characteristics of sodium starch glycolate tablets
title_full Effect of the applied pressure on the essential characteristics of sodium starch glycolate tablets
title_fullStr Effect of the applied pressure on the essential characteristics of sodium starch glycolate tablets
title_full_unstemmed Effect of the applied pressure on the essential characteristics of sodium starch glycolate tablets
title_sort effect of the applied pressure on the essential characteristics of sodium starch glycolate tablets
publisher IOP Publishing
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/79555/1/Effect%20of%20the%20applied%20pressure%20on%20the%20essential%20characteristics%20of%20sodium%20starch%20glycolate%20tablets.pdf
http://psasir.upm.edu.my/id/eprint/79555/
https://iopscience.iop.org/article/10.1088/1742-6596/1279/1/012028/meta
_version_ 1703962144112902144
score 13.211869

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