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Dimethyl sulfoxide and their toxicity

The aim of the present mini-review was to report a toxic effect of dimethyl sulfoxide (DMSO) that has indicated to change the histology of the liver and kidney of rats. DMSO is a powerful co-solvent and often is used in early metabolic studies when compounds are poorly characterized and difficult to...

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Main Authors: Jamil Abdulwahid Kurdi, Samiaa, Saulol Hamid, Nur Fazila, Ranneh, Yazan, Goh, Yong Meng, Hashim, Zailina
Format: Article
Language:English
Published: Green Publication 2019
Online Access:http://psasir.upm.edu.my/id/eprint/79391/1/Dimethyl%20sulfoxide%20and%20their%20toxicity%20.pdf
http://psasir.upm.edu.my/id/eprint/79391/
https://gnpublication.org/index.php/bp/article/view/1031
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spelling my.upm.eprints.793912021-03-30T23:14:25Z http://psasir.upm.edu.my/id/eprint/79391/ Dimethyl sulfoxide and their toxicity Jamil Abdulwahid Kurdi, Samiaa Saulol Hamid, Nur Fazila Ranneh, Yazan Goh, Yong Meng Hashim, Zailina The aim of the present mini-review was to report a toxic effect of dimethyl sulfoxide (DMSO) that has indicated to change the histology of the liver and kidney of rats. DMSO is a powerful co-solvent and often is used in early metabolic studies when compounds are poorly characterized and difficult to become soluble in water. To become soluble, they have to be dissolved in organic lipophilic solvents (vehicles). Following its conventional use, plant extract has been exposed to various intense and sub-acute toxicity studies to legitimize its toxicological security. Normally, DMSO has low fundamental toxicity yet plant extract when dissolved in 10% DSMO can cause noteworthy confined toxic impacts in the liver and kidney of rats. Be that as it may, vehicles currently in use have pleiotropic impacts, which are regularly obscure. Therefore, researchers ought to be cautious in the preparation and storage of substances before they are dispensed to animals. If this is not done, it may lead to accidental adverse effects on the animals and frequently result in inaccurate outcomes. In this mini-review, we summed up data on biological impacts of the DMSO most generally utilized lipophilic medication vehicles. Other than in experimental models, the information, where accessible, are presented on the impacts of solvents in therapeutic use in rodents. All in all, a few suggestions are given on the utilization of medication solvents in tests. Green Publication 2019-07 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/79391/1/Dimethyl%20sulfoxide%20and%20their%20toxicity%20.pdf Jamil Abdulwahid Kurdi, Samiaa and Saulol Hamid, Nur Fazila and Ranneh, Yazan and Goh, Yong Meng and Hashim, Zailina (2019) Dimethyl sulfoxide and their toxicity. International Journal For Research In Biology & Pharmacy, 5 (7). pp. 1-10. ISSN 2208-2093 https://gnpublication.org/index.php/bp/article/view/1031
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The aim of the present mini-review was to report a toxic effect of dimethyl sulfoxide (DMSO) that has indicated to change the histology of the liver and kidney of rats. DMSO is a powerful co-solvent and often is used in early metabolic studies when compounds are poorly characterized and difficult to become soluble in water. To become soluble, they have to be dissolved in organic lipophilic solvents (vehicles). Following its conventional use, plant extract has been exposed to various intense and sub-acute toxicity studies to legitimize its toxicological security. Normally, DMSO has low fundamental toxicity yet plant extract when dissolved in 10% DSMO can cause noteworthy confined toxic impacts in the liver and kidney of rats. Be that as it may, vehicles currently in use have pleiotropic impacts, which are regularly obscure. Therefore, researchers ought to be cautious in the preparation and storage of substances before they are dispensed to animals. If this is not done, it may lead to accidental adverse effects on the animals and frequently result in inaccurate outcomes. In this mini-review, we summed up data on biological impacts of the DMSO most generally utilized lipophilic medication vehicles. Other than in experimental models, the information, where accessible, are presented on the impacts of solvents in therapeutic use in rodents. All in all, a few suggestions are given on the utilization of medication solvents in tests.
format Article
author Jamil Abdulwahid Kurdi, Samiaa
Saulol Hamid, Nur Fazila
Ranneh, Yazan
Goh, Yong Meng
Hashim, Zailina
spellingShingle Jamil Abdulwahid Kurdi, Samiaa
Saulol Hamid, Nur Fazila
Ranneh, Yazan
Goh, Yong Meng
Hashim, Zailina
Dimethyl sulfoxide and their toxicity
author_facet Jamil Abdulwahid Kurdi, Samiaa
Saulol Hamid, Nur Fazila
Ranneh, Yazan
Goh, Yong Meng
Hashim, Zailina
author_sort Jamil Abdulwahid Kurdi, Samiaa
title Dimethyl sulfoxide and their toxicity
title_short Dimethyl sulfoxide and their toxicity
title_full Dimethyl sulfoxide and their toxicity
title_fullStr Dimethyl sulfoxide and their toxicity
title_full_unstemmed Dimethyl sulfoxide and their toxicity
title_sort dimethyl sulfoxide and their toxicity
publisher Green Publication
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/79391/1/Dimethyl%20sulfoxide%20and%20their%20toxicity%20.pdf
http://psasir.upm.edu.my/id/eprint/79391/
https://gnpublication.org/index.php/bp/article/view/1031
_version_ 1696977666856452096
score 13.211869

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