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Dietary fatty acid intake in hemodialysis patients and associations with circulating fatty acid profiles: a cross-sectional study

Objectives: The aims of this study were threefold: first, to assess the dietary fatty acid (FA) intake and blood FA status in Malaysian patients on hemodialysis (HD); second, to examine the association between dietary FA intakes and blood FA profiles in patients on HD; and third, to determine whethe...

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Main Authors: Khor, Ban Hock, Sahathevan, Sharmela, Sualeheen, Ayesha, Md Ali, Mohammad Syafiq, Narayanan, Sreelakshmi Sankara, Chinna, Karuthan, Abdul Gafor, Abdul Halim, Goh, Bak Leong, Ahmad, Ghazali, Morad, Zaki, Mat Daud, Zulfitri 'Azuan, Khosla, Pramod, Sundram, Kalyana, Karupaiah, Tilakavati
Format: Article
Language:English
Published: Oxford University Press 2019
Online Access:http://psasir.upm.edu.my/id/eprint/79382/1/Dietary%20fatty%20acid%20intake%20.pdf
http://psasir.upm.edu.my/id/eprint/79382/
https://www.sciencedirect.com/science/article/pii/S0899900718311092
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spelling my.upm.eprints.793822021-03-30T21:59:13Z http://psasir.upm.edu.my/id/eprint/79382/ Dietary fatty acid intake in hemodialysis patients and associations with circulating fatty acid profiles: a cross-sectional study Khor, Ban Hock Sahathevan, Sharmela Sualeheen, Ayesha Md Ali, Mohammad Syafiq Narayanan, Sreelakshmi Sankara Chinna, Karuthan Abdul Gafor, Abdul Halim Goh, Bak Leong Ahmad, Ghazali Morad, Zaki Mat Daud, Zulfitri 'Azuan Khosla, Pramod Sundram, Kalyana Karupaiah, Tilakavati Objectives: The aims of this study were threefold: first, to assess the dietary fatty acid (FA) intake and blood FA status in Malaysian patients on hemodialysis (HD); second, to examine the association between dietary FA intakes and blood FA profiles in patients on HD; and third, to determine whether blood FAs could serve as a biomarker of dietary fat intake quality in these patients. Methods: Using 3 d of dietary records, FA intakes of 333 recruited patients were calculated using a food database built from laboratory analyses of commonly consumed Malaysian foods. Plasma triacylglycerol (TG) and erythrocyte FAs were determined by gas chromatography. Results: High dietary saturated fatty acid (SFA) and monounsaturated fatty acid (MUFA) consumption trends were observed. Patients on HD also reported low dietary ω-3 and ω-6 polyunsaturated fatty acid (PUFA) consumptions and low levels of TG and erythrocyte FAs. TG and dietary FAs were significantly associated respective to total PUFA, total ω-6 PUFA, 18:2 ω-6, total ω-3 PUFA, 18:3 ω-3, 22:6 ω-3, and trans 18:2 isomers (P < 0.05). Contrarily, only dietary total ω-3 PUFA and 22:6 ω-3 were significantly associated with erythrocyte FAs (P < 0.01). The highest tertile of fish and shellfish consumption reflected a significantly higher proportion of TG 22:6 ω-3. Dietary SFAs were directly associated with TG and erythrocyte MUFA, whereas dietary PUFAs were not. Conclusion: TG and erythrocyte FAs serve as biomarkers of dietary PUFA intake in patients on HD. Elevation of circulating MUFA may be attributed to inadequate intake of PUFAs. Oxford University Press 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/79382/1/Dietary%20fatty%20acid%20intake%20.pdf Khor, Ban Hock and Sahathevan, Sharmela and Sualeheen, Ayesha and Md Ali, Mohammad Syafiq and Narayanan, Sreelakshmi Sankara and Chinna, Karuthan and Abdul Gafor, Abdul Halim and Goh, Bak Leong and Ahmad, Ghazali and Morad, Zaki and Mat Daud, Zulfitri 'Azuan and Khosla, Pramod and Sundram, Kalyana and Karupaiah, Tilakavati (2019) Dietary fatty acid intake in hemodialysis patients and associations with circulating fatty acid profiles: a cross-sectional study. Journal of Nutrition, 63-64. pp. 14-21. ISSN 0022-3166; ESSN: 1541-6100 https://www.sciencedirect.com/science/article/pii/S0899900718311092 10.1016/j.nut.2019.01.005
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Objectives: The aims of this study were threefold: first, to assess the dietary fatty acid (FA) intake and blood FA status in Malaysian patients on hemodialysis (HD); second, to examine the association between dietary FA intakes and blood FA profiles in patients on HD; and third, to determine whether blood FAs could serve as a biomarker of dietary fat intake quality in these patients. Methods: Using 3 d of dietary records, FA intakes of 333 recruited patients were calculated using a food database built from laboratory analyses of commonly consumed Malaysian foods. Plasma triacylglycerol (TG) and erythrocyte FAs were determined by gas chromatography. Results: High dietary saturated fatty acid (SFA) and monounsaturated fatty acid (MUFA) consumption trends were observed. Patients on HD also reported low dietary ω-3 and ω-6 polyunsaturated fatty acid (PUFA) consumptions and low levels of TG and erythrocyte FAs. TG and dietary FAs were significantly associated respective to total PUFA, total ω-6 PUFA, 18:2 ω-6, total ω-3 PUFA, 18:3 ω-3, 22:6 ω-3, and trans 18:2 isomers (P < 0.05). Contrarily, only dietary total ω-3 PUFA and 22:6 ω-3 were significantly associated with erythrocyte FAs (P < 0.01). The highest tertile of fish and shellfish consumption reflected a significantly higher proportion of TG 22:6 ω-3. Dietary SFAs were directly associated with TG and erythrocyte MUFA, whereas dietary PUFAs were not. Conclusion: TG and erythrocyte FAs serve as biomarkers of dietary PUFA intake in patients on HD. Elevation of circulating MUFA may be attributed to inadequate intake of PUFAs.
format Article
author Khor, Ban Hock
Sahathevan, Sharmela
Sualeheen, Ayesha
Md Ali, Mohammad Syafiq
Narayanan, Sreelakshmi Sankara
Chinna, Karuthan
Abdul Gafor, Abdul Halim
Goh, Bak Leong
Ahmad, Ghazali
Morad, Zaki
Mat Daud, Zulfitri 'Azuan
Khosla, Pramod
Sundram, Kalyana
Karupaiah, Tilakavati
spellingShingle Khor, Ban Hock
Sahathevan, Sharmela
Sualeheen, Ayesha
Md Ali, Mohammad Syafiq
Narayanan, Sreelakshmi Sankara
Chinna, Karuthan
Abdul Gafor, Abdul Halim
Goh, Bak Leong
Ahmad, Ghazali
Morad, Zaki
Mat Daud, Zulfitri 'Azuan
Khosla, Pramod
Sundram, Kalyana
Karupaiah, Tilakavati
Dietary fatty acid intake in hemodialysis patients and associations with circulating fatty acid profiles: a cross-sectional study
author_facet Khor, Ban Hock
Sahathevan, Sharmela
Sualeheen, Ayesha
Md Ali, Mohammad Syafiq
Narayanan, Sreelakshmi Sankara
Chinna, Karuthan
Abdul Gafor, Abdul Halim
Goh, Bak Leong
Ahmad, Ghazali
Morad, Zaki
Mat Daud, Zulfitri 'Azuan
Khosla, Pramod
Sundram, Kalyana
Karupaiah, Tilakavati
author_sort Khor, Ban Hock
title Dietary fatty acid intake in hemodialysis patients and associations with circulating fatty acid profiles: a cross-sectional study
title_short Dietary fatty acid intake in hemodialysis patients and associations with circulating fatty acid profiles: a cross-sectional study
title_full Dietary fatty acid intake in hemodialysis patients and associations with circulating fatty acid profiles: a cross-sectional study
title_fullStr Dietary fatty acid intake in hemodialysis patients and associations with circulating fatty acid profiles: a cross-sectional study
title_full_unstemmed Dietary fatty acid intake in hemodialysis patients and associations with circulating fatty acid profiles: a cross-sectional study
title_sort dietary fatty acid intake in hemodialysis patients and associations with circulating fatty acid profiles: a cross-sectional study
publisher Oxford University Press
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/79382/1/Dietary%20fatty%20acid%20intake%20.pdf
http://psasir.upm.edu.my/id/eprint/79382/
https://www.sciencedirect.com/science/article/pii/S0899900718311092
_version_ 1696977665869742080
score 13.211869

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