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Manipulation of microalgal lipid production: a genetic engineering aspect

Interests in microalgal lipids as green and renewable energy sources are piquing as cheap hydrocarbon fossil fuels reach their limit. Lipids from microalgae have important human uses, i.e., energy, food, and pharmaceuticals, depending on its quantity and quality. Genetic engineering is the introduct...

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Main Authors: Foo, Su Chern, Khong, Nicholas M.H., Md Yusoff, Fatimah
Other Authors: Alam, Md. Asraful
Format: Book Section
Language:English
Published: Springer 2019
Online Access:http://psasir.upm.edu.my/id/eprint/78854/1/Manipulation%20of%20microalgal%20lipid%20production.pdf
http://psasir.upm.edu.my/id/eprint/78854/
https://link.springer.com/chapter/10.1007/978-981-13-2264-8_9
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spelling my.upm.eprints.788542021-07-11T11:35:48Z http://psasir.upm.edu.my/id/eprint/78854/ Manipulation of microalgal lipid production: a genetic engineering aspect Foo, Su Chern Khong, Nicholas M.H. Md Yusoff, Fatimah Interests in microalgal lipids as green and renewable energy sources are piquing as cheap hydrocarbon fossil fuels reach their limit. Lipids from microalgae have important human uses, i.e., energy, food, and pharmaceuticals, depending on its quantity and quality. Genetic engineering is the introduction or suppression of a target gene for the selective expression of a bio-product, e.g., hydrocarbons for fuel or polyunsaturated fatty acids (PUFAs) for food, at a favorable quantity. Past studies like nitrogen starvation or salinity stress have shown to increase lipid contents of microalgae; however, studies on the molecular mechanisms underlying these stress-induced lipid productions remain limited. Next, complementing environmental stress manipulation with genetic engineering would potentially be a better and more effective approach to increase microalgae lipid production and accumulation. There are generally two approaches to enhance microalgae lipid production on a molecular level: firstly, overexpression and improvement of key enzymes involved in fatty acid and isoprenoid biosynthesis and, secondly, repression of lipid catabolic and competitive pathways such as beta-oxidation and starch synthesis. This review provides an update of microalgae lipid research findings to date and aims to address recent system biology discoveries and approaches on microalgae lipid production, the roadblocks encountered, and help needed to realize the ultimate goal, that is, microalgal lipids as sustainable resources for energy and high-value products. Springer Alam, Md. Asraful Wang, Zhongming 2019 Book Section PeerReviewed text en http://psasir.upm.edu.my/id/eprint/78854/1/Manipulation%20of%20microalgal%20lipid%20production.pdf Foo, Su Chern and Khong, Nicholas M.H. and Md Yusoff, Fatimah (2019) Manipulation of microalgal lipid production: a genetic engineering aspect. In: Microalgae Biotechnology for Development of Biofuel and Wastewater Treatment. Springer, Singapore, 179 - 209. ISBN 9789811322631; EISBN: 9789811322648 https://link.springer.com/chapter/10.1007/978-981-13-2264-8_9 10.1007/978-981-13-2264-8_9
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Interests in microalgal lipids as green and renewable energy sources are piquing as cheap hydrocarbon fossil fuels reach their limit. Lipids from microalgae have important human uses, i.e., energy, food, and pharmaceuticals, depending on its quantity and quality. Genetic engineering is the introduction or suppression of a target gene for the selective expression of a bio-product, e.g., hydrocarbons for fuel or polyunsaturated fatty acids (PUFAs) for food, at a favorable quantity. Past studies like nitrogen starvation or salinity stress have shown to increase lipid contents of microalgae; however, studies on the molecular mechanisms underlying these stress-induced lipid productions remain limited. Next, complementing environmental stress manipulation with genetic engineering would potentially be a better and more effective approach to increase microalgae lipid production and accumulation. There are generally two approaches to enhance microalgae lipid production on a molecular level: firstly, overexpression and improvement of key enzymes involved in fatty acid and isoprenoid biosynthesis and, secondly, repression of lipid catabolic and competitive pathways such as beta-oxidation and starch synthesis. This review provides an update of microalgae lipid research findings to date and aims to address recent system biology discoveries and approaches on microalgae lipid production, the roadblocks encountered, and help needed to realize the ultimate goal, that is, microalgal lipids as sustainable resources for energy and high-value products.
author2 Alam, Md. Asraful
author_facet Alam, Md. Asraful
Foo, Su Chern
Khong, Nicholas M.H.
Md Yusoff, Fatimah
format Book Section
author Foo, Su Chern
Khong, Nicholas M.H.
Md Yusoff, Fatimah
spellingShingle Foo, Su Chern
Khong, Nicholas M.H.
Md Yusoff, Fatimah
Manipulation of microalgal lipid production: a genetic engineering aspect
author_sort Foo, Su Chern
title Manipulation of microalgal lipid production: a genetic engineering aspect
title_short Manipulation of microalgal lipid production: a genetic engineering aspect
title_full Manipulation of microalgal lipid production: a genetic engineering aspect
title_fullStr Manipulation of microalgal lipid production: a genetic engineering aspect
title_full_unstemmed Manipulation of microalgal lipid production: a genetic engineering aspect
title_sort manipulation of microalgal lipid production: a genetic engineering aspect
publisher Springer
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/78854/1/Manipulation%20of%20microalgal%20lipid%20production.pdf
http://psasir.upm.edu.my/id/eprint/78854/
https://link.springer.com/chapter/10.1007/978-981-13-2264-8_9
_version_ 1705058432671809536
score 13.211869

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