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Hypocholesterolaemic and anti-atherogenic effects of palm-based oils (NoveLin I and NoveLin II) in cholesterol-fed rabbits

NoveLin I and NoveLin II are palm-based oils. NoveLin I has an equal distribution of saturated, monounsaturated and polyunsaturated fatty acids, whereas NoveLin II has a moderate level of monounsaturated fatty acids, and a lower content of saturated and polyunsaturated fatty acids. However, their hy...

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Main Authors: Che Idris, Che Anishas, Siew, Wai Lin, Abdull Razis, Ahmad Faizal
Format: Article
Language:English
Published: MDPI 2020
Online Access:http://psasir.upm.edu.my/id/eprint/78159/1/78159.pdf
http://psasir.upm.edu.my/id/eprint/78159/
https://www.mdpi.com/1660-4601/17/9/3226
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spelling my.upm.eprints.781592020-06-15T07:26:31Z http://psasir.upm.edu.my/id/eprint/78159/ Hypocholesterolaemic and anti-atherogenic effects of palm-based oils (NoveLin I and NoveLin II) in cholesterol-fed rabbits Che Idris, Che Anishas Siew, Wai Lin Abdull Razis, Ahmad Faizal NoveLin I and NoveLin II are palm-based oils. NoveLin I has an equal distribution of saturated, monounsaturated and polyunsaturated fatty acids, whereas NoveLin II has a moderate level of monounsaturated fatty acids, and a lower content of saturated and polyunsaturated fatty acids. However, their hypocholesterolaemic and anti-atherogenic effects have not been studied. Therefore, this study aimed to assess the hypocholesterolaemic and anti-atherogenic effects of these oils. Forty male New Zealand White rabbits were divided into four groups and fed with diets containing 35% energy fat with added 0.15% (w/w) dietary cholesterol. Group 1, as the control group (CNO) was fed with a diet containing coconut oil, group 2 and 3 were fed with diets containing either NoveLin I or NoveLin II, and group 4, was fed with diet containing olive oil (OLV) for 100 days. Our results demonstrated that both NoveLin groups have significantly lower total cholesterol and low-density lipoprotein–cholesterol (LDL–C) compared to CNO group and are comparable to the OLV group. Low density lipoprotein–cholesterol/high density lipoprotein-cholesterol (LDL/HDL–C) ratio was significantly lower after the NoveLin II diet but attained significance only in comparison to NoveLin I and CNO groups. Aortic fibrous plaque score was significantly lower in both NoveLin groups compared to CNO group. Our findings suggest that despite the high-fat cholesterol diet, NoveLin II oil resulted in atherogenic effects comparable to olive oil. MDPI 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/78159/1/78159.pdf Che Idris, Che Anishas and Siew, Wai Lin and Abdull Razis, Ahmad Faizal (2020) Hypocholesterolaemic and anti-atherogenic effects of palm-based oils (NoveLin I and NoveLin II) in cholesterol-fed rabbits. International Journal of Environmental Research and Public Health, 17 (9). art. no. 3226. pp. 1-10. ISSN 1661-7827; ESSN: 1660-4601 https://www.mdpi.com/1660-4601/17/9/3226 10.3390/ijerph17093226
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description NoveLin I and NoveLin II are palm-based oils. NoveLin I has an equal distribution of saturated, monounsaturated and polyunsaturated fatty acids, whereas NoveLin II has a moderate level of monounsaturated fatty acids, and a lower content of saturated and polyunsaturated fatty acids. However, their hypocholesterolaemic and anti-atherogenic effects have not been studied. Therefore, this study aimed to assess the hypocholesterolaemic and anti-atherogenic effects of these oils. Forty male New Zealand White rabbits were divided into four groups and fed with diets containing 35% energy fat with added 0.15% (w/w) dietary cholesterol. Group 1, as the control group (CNO) was fed with a diet containing coconut oil, group 2 and 3 were fed with diets containing either NoveLin I or NoveLin II, and group 4, was fed with diet containing olive oil (OLV) for 100 days. Our results demonstrated that both NoveLin groups have significantly lower total cholesterol and low-density lipoprotein–cholesterol (LDL–C) compared to CNO group and are comparable to the OLV group. Low density lipoprotein–cholesterol/high density lipoprotein-cholesterol (LDL/HDL–C) ratio was significantly lower after the NoveLin II diet but attained significance only in comparison to NoveLin I and CNO groups. Aortic fibrous plaque score was significantly lower in both NoveLin groups compared to CNO group. Our findings suggest that despite the high-fat cholesterol diet, NoveLin II oil resulted in atherogenic effects comparable to olive oil.
format Article
author Che Idris, Che Anishas
Siew, Wai Lin
Abdull Razis, Ahmad Faizal
spellingShingle Che Idris, Che Anishas
Siew, Wai Lin
Abdull Razis, Ahmad Faizal
Hypocholesterolaemic and anti-atherogenic effects of palm-based oils (NoveLin I and NoveLin II) in cholesterol-fed rabbits
author_facet Che Idris, Che Anishas
Siew, Wai Lin
Abdull Razis, Ahmad Faizal
author_sort Che Idris, Che Anishas
title Hypocholesterolaemic and anti-atherogenic effects of palm-based oils (NoveLin I and NoveLin II) in cholesterol-fed rabbits
title_short Hypocholesterolaemic and anti-atherogenic effects of palm-based oils (NoveLin I and NoveLin II) in cholesterol-fed rabbits
title_full Hypocholesterolaemic and anti-atherogenic effects of palm-based oils (NoveLin I and NoveLin II) in cholesterol-fed rabbits
title_fullStr Hypocholesterolaemic and anti-atherogenic effects of palm-based oils (NoveLin I and NoveLin II) in cholesterol-fed rabbits
title_full_unstemmed Hypocholesterolaemic and anti-atherogenic effects of palm-based oils (NoveLin I and NoveLin II) in cholesterol-fed rabbits
title_sort hypocholesterolaemic and anti-atherogenic effects of palm-based oils (novelin i and novelin ii) in cholesterol-fed rabbits
publisher MDPI
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/78159/1/78159.pdf
http://psasir.upm.edu.my/id/eprint/78159/
https://www.mdpi.com/1660-4601/17/9/3226
_version_ 1671341105107435520
score 13.244413

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