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The crosstalk between mesenchymal stem cells and damaged cartilage in osteoarthritis

Human cartilage contains multipotent stem cells, namely mesenchymal stem cells (MSCs) which are progenitors of connective tissue that play homeostatic and reparative roles. Although the major constituent cells in the cartilage are chondrocytes, they possess a limited regenerative ability, and as a r...

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Main Authors: Al-Graittee, Satar Jabbar Rahi, Ramasamy, Rajesh
Format: Article
Language:English
Published: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020
Online Access:http://psasir.upm.edu.my/id/eprint/77944/1/2020042010381637_MJMHS_0147.pdf
http://psasir.upm.edu.my/id/eprint/77944/
https://medic.upm.edu.my/upload/dokumen/2020042010381637_MJMHS_0147.pdf
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spelling my.upm.eprints.779442020-05-04T17:48:51Z http://psasir.upm.edu.my/id/eprint/77944/ The crosstalk between mesenchymal stem cells and damaged cartilage in osteoarthritis Al-Graittee, Satar Jabbar Rahi Ramasamy, Rajesh Human cartilage contains multipotent stem cells, namely mesenchymal stem cells (MSCs) which are progenitors of connective tissue that play homeostatic and reparative roles. Although the major constituent cells in the cartilage are chondrocytes, they possess a limited regenerative ability, and as a result, spontaneous cartilage repair by chondrocytes leads to the synthesis of fibrocartilage. Similarly, MSCs derived from articular cartilage of osteoarthritis patients have demonstrated inadequacy in cartilage repair. The role of MSCs in the pathophysiology of osteoarthritis (OA) is not entirely understood, whether the inflammatory milieu associated with OA joints affects the reparative properties of MSCs or the inherent defects of OA cartilage-derived MSCs impair the proper execution of the required immunosuppressive and reparative functions. Therefore, the current review explores the biological characteristics and features of MSCs derived from physiological state and OA condition with the aim of identifying how OA affects MSC functions as well as the role of MSCs in the pathophysiology of OA. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/77944/1/2020042010381637_MJMHS_0147.pdf Al-Graittee, Satar Jabbar Rahi and Ramasamy, Rajesh (2020) The crosstalk between mesenchymal stem cells and damaged cartilage in osteoarthritis. Malaysian Journal of Medicine and Health Sciences, 16 (2). pp. 262-268. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2020042010381637_MJMHS_0147.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Human cartilage contains multipotent stem cells, namely mesenchymal stem cells (MSCs) which are progenitors of connective tissue that play homeostatic and reparative roles. Although the major constituent cells in the cartilage are chondrocytes, they possess a limited regenerative ability, and as a result, spontaneous cartilage repair by chondrocytes leads to the synthesis of fibrocartilage. Similarly, MSCs derived from articular cartilage of osteoarthritis patients have demonstrated inadequacy in cartilage repair. The role of MSCs in the pathophysiology of osteoarthritis (OA) is not entirely understood, whether the inflammatory milieu associated with OA joints affects the reparative properties of MSCs or the inherent defects of OA cartilage-derived MSCs impair the proper execution of the required immunosuppressive and reparative functions. Therefore, the current review explores the biological characteristics and features of MSCs derived from physiological state and OA condition with the aim of identifying how OA affects MSC functions as well as the role of MSCs in the pathophysiology of OA.
format Article
author Al-Graittee, Satar Jabbar Rahi
Ramasamy, Rajesh
spellingShingle Al-Graittee, Satar Jabbar Rahi
Ramasamy, Rajesh
The crosstalk between mesenchymal stem cells and damaged cartilage in osteoarthritis
author_facet Al-Graittee, Satar Jabbar Rahi
Ramasamy, Rajesh
author_sort Al-Graittee, Satar Jabbar Rahi
title The crosstalk between mesenchymal stem cells and damaged cartilage in osteoarthritis
title_short The crosstalk between mesenchymal stem cells and damaged cartilage in osteoarthritis
title_full The crosstalk between mesenchymal stem cells and damaged cartilage in osteoarthritis
title_fullStr The crosstalk between mesenchymal stem cells and damaged cartilage in osteoarthritis
title_full_unstemmed The crosstalk between mesenchymal stem cells and damaged cartilage in osteoarthritis
title_sort crosstalk between mesenchymal stem cells and damaged cartilage in osteoarthritis
publisher Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/77944/1/2020042010381637_MJMHS_0147.pdf
http://psasir.upm.edu.my/id/eprint/77944/
https://medic.upm.edu.my/upload/dokumen/2020042010381637_MJMHS_0147.pdf
_version_ 1665896048791388160
score 13.211869

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