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Diabetes-associated autoantibodies among young diabetes mellitus patients in Malaysia

Introduction: Diabetes-associated autoantibodies (DAA) is the hallmark of T1DM and LADA which are frequently tested in young diabetes patients. It was noted that up to 10-15% of patients with initial diagnosis of T2DM also exhibit DAA. Regardless of the classification, the presence of DAA suggests a...

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Main Authors: Mahayidin, Hasni, Zakariah, Siti Zulaikha, Ishah, Noor Ashidah, Wee, Xu Ann, Mohamed Nor, Nurhanani, Arip, Masita
Format: Article
Language:English
Published: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020
Online Access:http://psasir.upm.edu.my/id/eprint/77935/1/2020042010163517_MJMHS_0516.pdf
http://psasir.upm.edu.my/id/eprint/77935/
https://medic.upm.edu.my/upload/dokumen/2020042010163517_MJMHS_0516.pdf
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spelling my.upm.eprints.779352020-05-04T17:47:04Z http://psasir.upm.edu.my/id/eprint/77935/ Diabetes-associated autoantibodies among young diabetes mellitus patients in Malaysia Mahayidin, Hasni Zakariah, Siti Zulaikha Ishah, Noor Ashidah Wee, Xu Ann Mohamed Nor, Nurhanani Arip, Masita Introduction: Diabetes-associated autoantibodies (DAA) is the hallmark of T1DM and LADA which are frequently tested in young diabetes patients. It was noted that up to 10-15% of patients with initial diagnosis of T2DM also exhibit DAA. Regardless of the classification, the presence of DAA suggests an underlying islet autoimmunity which lead to progressive pancreatic β-cell failure. There is limited data reported on DAA in young diabetes patients in Malaysia. This study aims to determine the frequency of DAA positivity and its association with demographic and clinical characteristics among this cohort. Methods: A retrospective study using secondary data obtained from Allergy and Immunology Research Centre, Institute for Medical Research, Malaysia. This study included 194 diabetes patients who were diagnosed before the age of 40 years old and tested for GADA, ICA, IA2A and IAA. Results: From 194 patients, 91 (46.9%) were positive for least one of the following DAA: ICA (79, 40.7%), GADA (61, 31.4%), IA2A (37, 19.1%) and IAA (9, 4.6%). Multiple positivity was higher (73.6%) compared to single positivity. Highest combination of double positivity was ICA+GADA (54, 59.3%) and triple positivity was ICA+GADA+IA2A (25, 27.5%). Simultaneous positivity of four autoantibodies was seen in only one (1.1%) patient. ICA, GADA and IA2A were associated with age group and ethnicity (all p < 0.001). Only IA2A was associated with gender (p = 0.012). Conclusions: GADA, ICA ad IA2A are more significant in young Malaysian diabetes patients. IAA has a very low frequency in this studied population. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/77935/1/2020042010163517_MJMHS_0516.pdf Mahayidin, Hasni and Zakariah, Siti Zulaikha and Ishah, Noor Ashidah and Wee, Xu Ann and Mohamed Nor, Nurhanani and Arip, Masita (2020) Diabetes-associated autoantibodies among young diabetes mellitus patients in Malaysia. Malaysian Journal of Medicine and Health Sciences, 16 (2). pp. 118-125. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2020042010163517_MJMHS_0516.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Introduction: Diabetes-associated autoantibodies (DAA) is the hallmark of T1DM and LADA which are frequently tested in young diabetes patients. It was noted that up to 10-15% of patients with initial diagnosis of T2DM also exhibit DAA. Regardless of the classification, the presence of DAA suggests an underlying islet autoimmunity which lead to progressive pancreatic β-cell failure. There is limited data reported on DAA in young diabetes patients in Malaysia. This study aims to determine the frequency of DAA positivity and its association with demographic and clinical characteristics among this cohort. Methods: A retrospective study using secondary data obtained from Allergy and Immunology Research Centre, Institute for Medical Research, Malaysia. This study included 194 diabetes patients who were diagnosed before the age of 40 years old and tested for GADA, ICA, IA2A and IAA. Results: From 194 patients, 91 (46.9%) were positive for least one of the following DAA: ICA (79, 40.7%), GADA (61, 31.4%), IA2A (37, 19.1%) and IAA (9, 4.6%). Multiple positivity was higher (73.6%) compared to single positivity. Highest combination of double positivity was ICA+GADA (54, 59.3%) and triple positivity was ICA+GADA+IA2A (25, 27.5%). Simultaneous positivity of four autoantibodies was seen in only one (1.1%) patient. ICA, GADA and IA2A were associated with age group and ethnicity (all p < 0.001). Only IA2A was associated with gender (p = 0.012). Conclusions: GADA, ICA ad IA2A are more significant in young Malaysian diabetes patients. IAA has a very low frequency in this studied population.
format Article
author Mahayidin, Hasni
Zakariah, Siti Zulaikha
Ishah, Noor Ashidah
Wee, Xu Ann
Mohamed Nor, Nurhanani
Arip, Masita
spellingShingle Mahayidin, Hasni
Zakariah, Siti Zulaikha
Ishah, Noor Ashidah
Wee, Xu Ann
Mohamed Nor, Nurhanani
Arip, Masita
Diabetes-associated autoantibodies among young diabetes mellitus patients in Malaysia
author_facet Mahayidin, Hasni
Zakariah, Siti Zulaikha
Ishah, Noor Ashidah
Wee, Xu Ann
Mohamed Nor, Nurhanani
Arip, Masita
author_sort Mahayidin, Hasni
title Diabetes-associated autoantibodies among young diabetes mellitus patients in Malaysia
title_short Diabetes-associated autoantibodies among young diabetes mellitus patients in Malaysia
title_full Diabetes-associated autoantibodies among young diabetes mellitus patients in Malaysia
title_fullStr Diabetes-associated autoantibodies among young diabetes mellitus patients in Malaysia
title_full_unstemmed Diabetes-associated autoantibodies among young diabetes mellitus patients in Malaysia
title_sort diabetes-associated autoantibodies among young diabetes mellitus patients in malaysia
publisher Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/77935/1/2020042010163517_MJMHS_0516.pdf
http://psasir.upm.edu.my/id/eprint/77935/
https://medic.upm.edu.my/upload/dokumen/2020042010163517_MJMHS_0516.pdf
_version_ 1665896047917924352
score 13.211869

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