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Effects of oral fatty acid on left ventricular 2-[18F] Fluoro-2-Deoxy-D-Glucose uptake during whole body positron emission and computed tomography

Background: There are two main myocardial metabolic pathways including glucose oxidative pathway and free fatty acid (FFA) oxidative pathway. FFA is the major source of energy for the heart, generating 60% to 90% of energy while glucose metabolism produces the rest 10% to 40% of energy depending on...

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Main Author: Che Nordin, Mohd Nazmi
Format: Thesis
Language:English
Published: 2016
Online Access:http://psasir.upm.edu.my/id/eprint/75323/1/FPSK%28M%29%202016%2040%20IR.pdf
http://psasir.upm.edu.my/id/eprint/75323/
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spelling my.upm.eprints.753232019-10-17T08:59:35Z http://psasir.upm.edu.my/id/eprint/75323/ Effects of oral fatty acid on left ventricular 2-[18F] Fluoro-2-Deoxy-D-Glucose uptake during whole body positron emission and computed tomography Che Nordin, Mohd Nazmi Background: There are two main myocardial metabolic pathways including glucose oxidative pathway and free fatty acid (FFA) oxidative pathway. FFA is the major source of energy for the heart, generating 60% to 90% of energy while glucose metabolism produces the rest 10% to 40% of energy depending on physiological conditions. Objective: This study was carried out to observe the intensity and to analyze the differences in the intensity of 18F-FDG uptake in the wall of LV WITH and WITHOUT oral ingestion of edible oils during whole body (WB) 18F-FDG PET/CT study. Methodology: This is a prospective study involving patients undergoing modified WB 18F-FDG PET/CT protocol; [Group A (n=12) : WB + oral ingestion of 50ml virgin coconut oil (VCO); Group B (n=9) : WB + oral ingestion of 50ml olive oil(OO)]. And Group C (n=9) applied standard preparation protocol for WB 18F-FDG PET/CT examination. The 18FFDG uptake in the wall of LV was qualitatively and quantitatively assessed. Results: The mean age for group A, B, and C were 49.25 ± 13.19, 56.11 ± 11.66 and 64.33 ± 7.50. The mean BMI were 22.46 ± 3.83, 25.68 ± 5.66 and 26.74 ± 4.26 respectively, while the mean FBS were 5.80 ± 1.23, 5.60 ± 1.61 and 5.73 ± 0.51 respectively. The LV uptake of 18F-FDG was significantly higher in Group C patients. There was a significant difference in mean SUVmax at mid (2.58 ± 3.97 vs 2.28 ± 2.75 vs 6.59 ± 2.09, p=0.002), basal (6.43 ± 8.57 vs 4.87 ± 3.08 vs 13.89 ± 3.77, p=0.005) and apical (6.37 ± 8.27 vs 5.33 ± 3.22 vs 11.42 ± 4.66, p=0.002) of LV. The mean normalized 18F-FDG distribution in 20-segment polar map expressed in percentage for Group B was lower in comparison to Group A and Group C (66.37% vs 63.13% vs 68.78%, p=0.04). Conclusion: Oral ingestion of edible oils leads to preference towards fatty metabolism of myocardium hence reduction in glucose uptake. 2016-08 Thesis NonPeerReviewed text en http://psasir.upm.edu.my/id/eprint/75323/1/FPSK%28M%29%202016%2040%20IR.pdf Che Nordin, Mohd Nazmi (2016) Effects of oral fatty acid on left ventricular 2-[18F] Fluoro-2-Deoxy-D-Glucose uptake during whole body positron emission and computed tomography. Masters thesis, Universiti Putra Malaysia.
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Background: There are two main myocardial metabolic pathways including glucose oxidative pathway and free fatty acid (FFA) oxidative pathway. FFA is the major source of energy for the heart, generating 60% to 90% of energy while glucose metabolism produces the rest 10% to 40% of energy depending on physiological conditions. Objective: This study was carried out to observe the intensity and to analyze the differences in the intensity of 18F-FDG uptake in the wall of LV WITH and WITHOUT oral ingestion of edible oils during whole body (WB) 18F-FDG PET/CT study. Methodology: This is a prospective study involving patients undergoing modified WB 18F-FDG PET/CT protocol; [Group A (n=12) : WB + oral ingestion of 50ml virgin coconut oil (VCO); Group B (n=9) : WB + oral ingestion of 50ml olive oil(OO)]. And Group C (n=9) applied standard preparation protocol for WB 18F-FDG PET/CT examination. The 18FFDG uptake in the wall of LV was qualitatively and quantitatively assessed. Results: The mean age for group A, B, and C were 49.25 ± 13.19, 56.11 ± 11.66 and 64.33 ± 7.50. The mean BMI were 22.46 ± 3.83, 25.68 ± 5.66 and 26.74 ± 4.26 respectively, while the mean FBS were 5.80 ± 1.23, 5.60 ± 1.61 and 5.73 ± 0.51 respectively. The LV uptake of 18F-FDG was significantly higher in Group C patients. There was a significant difference in mean SUVmax at mid (2.58 ± 3.97 vs 2.28 ± 2.75 vs 6.59 ± 2.09, p=0.002), basal (6.43 ± 8.57 vs 4.87 ± 3.08 vs 13.89 ± 3.77, p=0.005) and apical (6.37 ± 8.27 vs 5.33 ± 3.22 vs 11.42 ± 4.66, p=0.002) of LV. The mean normalized 18F-FDG distribution in 20-segment polar map expressed in percentage for Group B was lower in comparison to Group A and Group C (66.37% vs 63.13% vs 68.78%, p=0.04). Conclusion: Oral ingestion of edible oils leads to preference towards fatty metabolism of myocardium hence reduction in glucose uptake.
format Thesis
author Che Nordin, Mohd Nazmi
spellingShingle Che Nordin, Mohd Nazmi
Effects of oral fatty acid on left ventricular 2-[18F] Fluoro-2-Deoxy-D-Glucose uptake during whole body positron emission and computed tomography
author_facet Che Nordin, Mohd Nazmi
author_sort Che Nordin, Mohd Nazmi
title Effects of oral fatty acid on left ventricular 2-[18F] Fluoro-2-Deoxy-D-Glucose uptake during whole body positron emission and computed tomography
title_short Effects of oral fatty acid on left ventricular 2-[18F] Fluoro-2-Deoxy-D-Glucose uptake during whole body positron emission and computed tomography
title_full Effects of oral fatty acid on left ventricular 2-[18F] Fluoro-2-Deoxy-D-Glucose uptake during whole body positron emission and computed tomography
title_fullStr Effects of oral fatty acid on left ventricular 2-[18F] Fluoro-2-Deoxy-D-Glucose uptake during whole body positron emission and computed tomography
title_full_unstemmed Effects of oral fatty acid on left ventricular 2-[18F] Fluoro-2-Deoxy-D-Glucose uptake during whole body positron emission and computed tomography
title_sort effects of oral fatty acid on left ventricular 2-[18f] fluoro-2-deoxy-d-glucose uptake during whole body positron emission and computed tomography
publishDate 2016
url http://psasir.upm.edu.my/id/eprint/75323/1/FPSK%28M%29%202016%2040%20IR.pdf
http://psasir.upm.edu.my/id/eprint/75323/
_version_ 1648738198206021632
score 13.223943

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