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Ocular blood flow in rabbits under deep anesthesia: a real-time measurement technique and its application in characterizing retinal ischemia

In this study, we reported a new technique based on laser speckle flowgraphy to record the ocular blood flow in rabbits under deep anesthesia, and proposed parameters to characterize retinal ischemia. We applied the proposed technique to study the correlation of blood flow between the eyes of normal...

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Main Authors: Bhatti, Mehwish Saba, Tang, Tong Boon, Chen, Hui Cheng
Format: Article
Language:English
Published: Nature Research 2018
Online Access:http://psasir.upm.edu.my/id/eprint/75117/1/Ocular%20blood%20flow%20in%20rabbits%20.pdf
http://psasir.upm.edu.my/id/eprint/75117/
https://www.nature.com/articles/s41598-018-24141-4
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spelling my.upm.eprints.751172021-09-08T09:38:13Z http://psasir.upm.edu.my/id/eprint/75117/ Ocular blood flow in rabbits under deep anesthesia: a real-time measurement technique and its application in characterizing retinal ischemia Bhatti, Mehwish Saba Tang, Tong Boon Chen, Hui Cheng In this study, we reported a new technique based on laser speckle flowgraphy to record the ocular blood flow in rabbits under deep anesthesia, and proposed parameters to characterize retinal ischemia. We applied the proposed technique to study the correlation of blood flow between the eyes of normal non-anesthetized animals, and to characterize the occlusion of the internal carotid artery (ICA) and external carotid artery (ECA). We established a correlation in blood flow between the eyes of non-anesthetized animals, and derived two new parameters, namely, the laterality index and vascular perfusion estimate (VPE). Our experimental results from 16 eyes (of 13 New Zealand white rabbits) showed a reduction in ocular blood flow with a significant decrease in the VPE after the occlusion of the ECA (p < 0.001). A low/minimal effect on blood flow was observed with the occlusion of the ICA. In conclusion, we demonstrated a means for the real-time measurement of the ocular blood flow in rabbits under deep anesthesia by using laser speckle flowgraphy and the VPE as an indicator of successful occlusion. The proposed technique might be applicable in quantifying the efficacy of new drugs and interventions for the treatment of retinal ischemia. Nature Research 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/75117/1/Ocular%20blood%20flow%20in%20rabbits%20.pdf Bhatti, Mehwish Saba and Tang, Tong Boon and Chen, Hui Cheng (2018) Ocular blood flow in rabbits under deep anesthesia: a real-time measurement technique and its application in characterizing retinal ischemia. Scientific Reports, 8 (1). art. no. 5713. pp. 1-9. ISSN 2045-2322 https://www.nature.com/articles/s41598-018-24141-4 10.1038/s41598-018-24141-4
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description In this study, we reported a new technique based on laser speckle flowgraphy to record the ocular blood flow in rabbits under deep anesthesia, and proposed parameters to characterize retinal ischemia. We applied the proposed technique to study the correlation of blood flow between the eyes of normal non-anesthetized animals, and to characterize the occlusion of the internal carotid artery (ICA) and external carotid artery (ECA). We established a correlation in blood flow between the eyes of non-anesthetized animals, and derived two new parameters, namely, the laterality index and vascular perfusion estimate (VPE). Our experimental results from 16 eyes (of 13 New Zealand white rabbits) showed a reduction in ocular blood flow with a significant decrease in the VPE after the occlusion of the ECA (p < 0.001). A low/minimal effect on blood flow was observed with the occlusion of the ICA. In conclusion, we demonstrated a means for the real-time measurement of the ocular blood flow in rabbits under deep anesthesia by using laser speckle flowgraphy and the VPE as an indicator of successful occlusion. The proposed technique might be applicable in quantifying the efficacy of new drugs and interventions for the treatment of retinal ischemia.
format Article
author Bhatti, Mehwish Saba
Tang, Tong Boon
Chen, Hui Cheng
spellingShingle Bhatti, Mehwish Saba
Tang, Tong Boon
Chen, Hui Cheng
Ocular blood flow in rabbits under deep anesthesia: a real-time measurement technique and its application in characterizing retinal ischemia
author_facet Bhatti, Mehwish Saba
Tang, Tong Boon
Chen, Hui Cheng
author_sort Bhatti, Mehwish Saba
title Ocular blood flow in rabbits under deep anesthesia: a real-time measurement technique and its application in characterizing retinal ischemia
title_short Ocular blood flow in rabbits under deep anesthesia: a real-time measurement technique and its application in characterizing retinal ischemia
title_full Ocular blood flow in rabbits under deep anesthesia: a real-time measurement technique and its application in characterizing retinal ischemia
title_fullStr Ocular blood flow in rabbits under deep anesthesia: a real-time measurement technique and its application in characterizing retinal ischemia
title_full_unstemmed Ocular blood flow in rabbits under deep anesthesia: a real-time measurement technique and its application in characterizing retinal ischemia
title_sort ocular blood flow in rabbits under deep anesthesia: a real-time measurement technique and its application in characterizing retinal ischemia
publisher Nature Research
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/75117/1/Ocular%20blood%20flow%20in%20rabbits%20.pdf
http://psasir.upm.edu.my/id/eprint/75117/
https://www.nature.com/articles/s41598-018-24141-4
_version_ 1710677140882587648
score 13.211869

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