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Impact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of F-18 fluorocholine synthesis

Objective: The goal of this preliminary work was to observe the impact of the prolonged reduced-pressure condition prior to labeling stage on the F-18 Fluorocholine labeling yield at the end of synthesis.Methods: At this present work, the condition inside the reactor vial prior to labeling stage was...

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Main Authors: Hassan, Hishar, Hanafi, Muhammad Hafiz, A S, Fathinul Fikri
Format: Article
Language:English
Published: 2018
Online Access:http://psasir.upm.edu.my/id/eprint/74575/1/Impact%20of%20prolonged.pdf
http://psasir.upm.edu.my/id/eprint/74575/
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spelling my.upm.eprints.745752020-03-17T08:13:54Z http://psasir.upm.edu.my/id/eprint/74575/ Impact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of F-18 fluorocholine synthesis Hassan, Hishar Hanafi, Muhammad Hafiz A S, Fathinul Fikri Objective: The goal of this preliminary work was to observe the impact of the prolonged reduced-pressure condition prior to labeling stage on the F-18 Fluorocholine labeling yield at the end of synthesis.Methods: At this present work, the condition inside the reactor vial prior to labeling stage was manipulated. In the first technique of syntheses of F-18 Fluorocholine, the condition inside the reactor vial was set at 0 atmospheric pressure (0 atm) while in the second technique the condition inside the reactor was set at reduced-pressure (between-0.65 to-0.85 bars) with the delay time of 120 seconds. At the end of the synthesis, the impact of the prolonged reduced-pressure condition prior to precursor labeling was measured in terms of labeling yield of F-18 Fluorocholine. Results: With the second technique, the labeling yield of F-18 Fluorocholine was elevated from 9.7% (the first technique) to 24.3%.Conclusion: This preliminary work indicates that delay in a reduced-pressure condition prior to labeling step has greatly improved the labeling yield of F-18 Fluorocholine at the end of synthesis. Using this approach, the labeling yield of F-18 Fluorocholine was elevated from 7.5% to 24.3%. 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/74575/1/Impact%20of%20prolonged.pdf Hassan, Hishar and Hanafi, Muhammad Hafiz and A S, Fathinul Fikri (2018) Impact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of F-18 fluorocholine synthesis. International Journal of Pharmacy and Pharmaceutical Sciences, 10 (4). 143 - 145. ISSN 0975-1491 10.22159/ijpps.2018v10i4.23057
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Objective: The goal of this preliminary work was to observe the impact of the prolonged reduced-pressure condition prior to labeling stage on the F-18 Fluorocholine labeling yield at the end of synthesis.Methods: At this present work, the condition inside the reactor vial prior to labeling stage was manipulated. In the first technique of syntheses of F-18 Fluorocholine, the condition inside the reactor vial was set at 0 atmospheric pressure (0 atm) while in the second technique the condition inside the reactor was set at reduced-pressure (between-0.65 to-0.85 bars) with the delay time of 120 seconds. At the end of the synthesis, the impact of the prolonged reduced-pressure condition prior to precursor labeling was measured in terms of labeling yield of F-18 Fluorocholine. Results: With the second technique, the labeling yield of F-18 Fluorocholine was elevated from 9.7% (the first technique) to 24.3%.Conclusion: This preliminary work indicates that delay in a reduced-pressure condition prior to labeling step has greatly improved the labeling yield of F-18 Fluorocholine at the end of synthesis. Using this approach, the labeling yield of F-18 Fluorocholine was elevated from 7.5% to 24.3%.
format Article
author Hassan, Hishar
Hanafi, Muhammad Hafiz
A S, Fathinul Fikri
spellingShingle Hassan, Hishar
Hanafi, Muhammad Hafiz
A S, Fathinul Fikri
Impact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of F-18 fluorocholine synthesis
author_facet Hassan, Hishar
Hanafi, Muhammad Hafiz
A S, Fathinul Fikri
author_sort Hassan, Hishar
title Impact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of F-18 fluorocholine synthesis
title_short Impact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of F-18 fluorocholine synthesis
title_full Impact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of F-18 fluorocholine synthesis
title_fullStr Impact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of F-18 fluorocholine synthesis
title_full_unstemmed Impact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of F-18 fluorocholine synthesis
title_sort impact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of f-18 fluorocholine synthesis
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/74575/1/Impact%20of%20prolonged.pdf
http://psasir.upm.edu.my/id/eprint/74575/
_version_ 1662756494001569792
score 13.211869

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