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Skin and eye irritation assessment of oil palm (Elaeis guineensis) leaf extract for topical application

Many types of phytochemicals have been found to be present in oil palm leaf and could potentially be used as functional ingredients for skincare product. However, as of today, there is no published report on hazard identification and safety assessment of oil palm ( Elaeis guineensis) leaf extract (O...

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Main Authors: Yusof, Nor Zuliana, Abd Gani, Siti Salwa, Azizul Hasan, Zafarizal Aldrin, Idris, Zainab
Format: Article
Language:English
Published: SAGE Publications 2018
Online Access:http://psasir.upm.edu.my/id/eprint/73902/1/Skin%20and%20eye%20irritation%20assessment%20of%20oil%20palm%20%28Elaeis%20guineensis%29%20leaf%20extract%20for%20topical%20application.pdf
http://psasir.upm.edu.my/id/eprint/73902/
https://journals.sagepub.com/doi/full/10.1177/1091581818773979?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
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spelling my.upm.eprints.739022020-05-17T17:46:14Z http://psasir.upm.edu.my/id/eprint/73902/ Skin and eye irritation assessment of oil palm (Elaeis guineensis) leaf extract for topical application Yusof, Nor Zuliana Abd Gani, Siti Salwa Azizul Hasan, Zafarizal Aldrin Idris, Zainab Many types of phytochemicals have been found to be present in oil palm leaf and could potentially be used as functional ingredients for skincare product. However, as of today, there is no published report on hazard identification and safety assessment of oil palm ( Elaeis guineensis) leaf extract (OPLE), particularly on skin and eye irritation. In this study, potential hazard of OPLE on skin and eye irritation was evaluated as an initial step to the safety assessment of OPLE. In vitro cell viability study of OPLE on normal human dermal fibroblasts showed that OPLE was nontoxic to the cells with percentage viability more than 90% after 24 and 48 hours of incubation. Skin irritation potential of OPLE was evaluated using in vitro SkinEthic reconstructed human epidermis (RHE) model (Organization for Economic Cooperation and Development [OECD] Test Guideline 439, 2015), while eye irritation potential was evaluated using in vitro SkinEthic Human corneal epithelium (HCE) model (OECD test guideline 492, 2017). Hazard identification results showed that OPLE at 1%, 5%, and 10% (wt/wt) was classified as nonirritant to the skin and eye where mean tissue viabilities of SkinEthic RHE and SkinEthic HCE were more than 50% and 60%, respectively. Therefore, we recommend a further safety assessment, such as human patch testing, to confirm the nonirritant of OPLE. SAGE Publications 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/73902/1/Skin%20and%20eye%20irritation%20assessment%20of%20oil%20palm%20%28Elaeis%20guineensis%29%20leaf%20extract%20for%20topical%20application.pdf Yusof, Nor Zuliana and Abd Gani, Siti Salwa and Azizul Hasan, Zafarizal Aldrin and Idris, Zainab (2018) Skin and eye irritation assessment of oil palm (Elaeis guineensis) leaf extract for topical application. International Journal of Toxicology, 37 (4). 335 - 343. ISSN 1091-5818; ESSN: 1092-874X https://journals.sagepub.com/doi/full/10.1177/1091581818773979?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed 10.1177/1091581818773979
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Many types of phytochemicals have been found to be present in oil palm leaf and could potentially be used as functional ingredients for skincare product. However, as of today, there is no published report on hazard identification and safety assessment of oil palm ( Elaeis guineensis) leaf extract (OPLE), particularly on skin and eye irritation. In this study, potential hazard of OPLE on skin and eye irritation was evaluated as an initial step to the safety assessment of OPLE. In vitro cell viability study of OPLE on normal human dermal fibroblasts showed that OPLE was nontoxic to the cells with percentage viability more than 90% after 24 and 48 hours of incubation. Skin irritation potential of OPLE was evaluated using in vitro SkinEthic reconstructed human epidermis (RHE) model (Organization for Economic Cooperation and Development [OECD] Test Guideline 439, 2015), while eye irritation potential was evaluated using in vitro SkinEthic Human corneal epithelium (HCE) model (OECD test guideline 492, 2017). Hazard identification results showed that OPLE at 1%, 5%, and 10% (wt/wt) was classified as nonirritant to the skin and eye where mean tissue viabilities of SkinEthic RHE and SkinEthic HCE were more than 50% and 60%, respectively. Therefore, we recommend a further safety assessment, such as human patch testing, to confirm the nonirritant of OPLE.
format Article
author Yusof, Nor Zuliana
Abd Gani, Siti Salwa
Azizul Hasan, Zafarizal Aldrin
Idris, Zainab
spellingShingle Yusof, Nor Zuliana
Abd Gani, Siti Salwa
Azizul Hasan, Zafarizal Aldrin
Idris, Zainab
Skin and eye irritation assessment of oil palm (Elaeis guineensis) leaf extract for topical application
author_facet Yusof, Nor Zuliana
Abd Gani, Siti Salwa
Azizul Hasan, Zafarizal Aldrin
Idris, Zainab
author_sort Yusof, Nor Zuliana
title Skin and eye irritation assessment of oil palm (Elaeis guineensis) leaf extract for topical application
title_short Skin and eye irritation assessment of oil palm (Elaeis guineensis) leaf extract for topical application
title_full Skin and eye irritation assessment of oil palm (Elaeis guineensis) leaf extract for topical application
title_fullStr Skin and eye irritation assessment of oil palm (Elaeis guineensis) leaf extract for topical application
title_full_unstemmed Skin and eye irritation assessment of oil palm (Elaeis guineensis) leaf extract for topical application
title_sort skin and eye irritation assessment of oil palm (elaeis guineensis) leaf extract for topical application
publisher SAGE Publications
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/73902/1/Skin%20and%20eye%20irritation%20assessment%20of%20oil%20palm%20%28Elaeis%20guineensis%29%20leaf%20extract%20for%20topical%20application.pdf
http://psasir.upm.edu.my/id/eprint/73902/
https://journals.sagepub.com/doi/full/10.1177/1091581818773979?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
_version_ 1669008834887155712
score 13.211869

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