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Recent updates on phthalate exposure and human health: a special focus on liver toxicity and stem cell regeneration

Phthalates have been blended in various compositions as plasticizers worldwide for a variety of purposes. Consequently, humans are exposed to a wide spectrum of phthalates that needs to be researched and understood correctly. The goal of this review is to focus on phthalate's internal exposure...

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Main Authors: Praveena, Sarva Mangala, Seoh, Wei Teh, Rajendran, Ranjith Kumar, Kannan, Narayanan, Chu, Ching Lin, Abdullah, Rozaini, Kumar, Suresh
Format: Article
Language:English
Published: Springer 2018
Online Access:http://psasir.upm.edu.my/id/eprint/73719/1/Recent%20updates%20on%20phthalate%20exposure%20and%20human%20health%20a%20special%20focus%20on%20liver%20toxicity%20and%20stem%20cell%20regeneration.pdf
http://psasir.upm.edu.my/id/eprint/73719/
https://link.springer.com/article/10.1007%2Fs11356-018-1652-8
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spelling my.upm.eprints.737192020-05-08T16:49:43Z http://psasir.upm.edu.my/id/eprint/73719/ Recent updates on phthalate exposure and human health: a special focus on liver toxicity and stem cell regeneration Praveena, Sarva Mangala Seoh, Wei Teh Rajendran, Ranjith Kumar Kannan, Narayanan Chu, Ching Lin Abdullah, Rozaini Kumar, Suresh Phthalates have been blended in various compositions as plasticizers worldwide for a variety of purposes. Consequently, humans are exposed to a wide spectrum of phthalates that needs to be researched and understood correctly. The goal of this review is to focus on phthalate's internal exposure pathways and possible role of human digestion on liver toxicity. In addition, special focus was made on stem cell therapy in reverting liver toxicity. The known entry of higher molecular weight phthalates is through ingestion while inhalation and dermal pathways are for lower molecular weight phthalates. In human body, certain phthalates are digested through phase 1 (hydrolysis, oxidation) and phase 2 (conjugation) metabolic processes. The phthalates that are made bioavailable through digestion enter the blood stream and reach the liver for further detoxification, and these are excreted via urine and/or feces. Bis(2-ethylhexyl) phthalate (DEHP) is a compound well studied involving human metabolism. Liver plays a pivotal role in humans for detoxification of pollutants. Thus, continuous exposure to phthalates in humans may lead to inhibition of liver detoxifying enzymes and may result in liver dysfunction. The potential of stem cell therapy addressed herewith will revert liver dysfunction and lead to restoration of liver function properly. Springer 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/73719/1/Recent%20updates%20on%20phthalate%20exposure%20and%20human%20health%20a%20special%20focus%20on%20liver%20toxicity%20and%20stem%20cell%20regeneration.pdf Praveena, Sarva Mangala and Seoh, Wei Teh and Rajendran, Ranjith Kumar and Kannan, Narayanan and Chu, Ching Lin and Abdullah, Rozaini and Kumar, Suresh (2018) Recent updates on phthalate exposure and human health: a special focus on liver toxicity and stem cell regeneration. Environmental Science and Pollution Research, 25 (12). 11333 - 11342. ISSN 0944-1344; ESSN: 1614-7499 https://link.springer.com/article/10.1007%2Fs11356-018-1652-8 10.1007/s11356-018-1652-8
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Phthalates have been blended in various compositions as plasticizers worldwide for a variety of purposes. Consequently, humans are exposed to a wide spectrum of phthalates that needs to be researched and understood correctly. The goal of this review is to focus on phthalate's internal exposure pathways and possible role of human digestion on liver toxicity. In addition, special focus was made on stem cell therapy in reverting liver toxicity. The known entry of higher molecular weight phthalates is through ingestion while inhalation and dermal pathways are for lower molecular weight phthalates. In human body, certain phthalates are digested through phase 1 (hydrolysis, oxidation) and phase 2 (conjugation) metabolic processes. The phthalates that are made bioavailable through digestion enter the blood stream and reach the liver for further detoxification, and these are excreted via urine and/or feces. Bis(2-ethylhexyl) phthalate (DEHP) is a compound well studied involving human metabolism. Liver plays a pivotal role in humans for detoxification of pollutants. Thus, continuous exposure to phthalates in humans may lead to inhibition of liver detoxifying enzymes and may result in liver dysfunction. The potential of stem cell therapy addressed herewith will revert liver dysfunction and lead to restoration of liver function properly.
format Article
author Praveena, Sarva Mangala
Seoh, Wei Teh
Rajendran, Ranjith Kumar
Kannan, Narayanan
Chu, Ching Lin
Abdullah, Rozaini
Kumar, Suresh
spellingShingle Praveena, Sarva Mangala
Seoh, Wei Teh
Rajendran, Ranjith Kumar
Kannan, Narayanan
Chu, Ching Lin
Abdullah, Rozaini
Kumar, Suresh
Recent updates on phthalate exposure and human health: a special focus on liver toxicity and stem cell regeneration
author_facet Praveena, Sarva Mangala
Seoh, Wei Teh
Rajendran, Ranjith Kumar
Kannan, Narayanan
Chu, Ching Lin
Abdullah, Rozaini
Kumar, Suresh
author_sort Praveena, Sarva Mangala
title Recent updates on phthalate exposure and human health: a special focus on liver toxicity and stem cell regeneration
title_short Recent updates on phthalate exposure and human health: a special focus on liver toxicity and stem cell regeneration
title_full Recent updates on phthalate exposure and human health: a special focus on liver toxicity and stem cell regeneration
title_fullStr Recent updates on phthalate exposure and human health: a special focus on liver toxicity and stem cell regeneration
title_full_unstemmed Recent updates on phthalate exposure and human health: a special focus on liver toxicity and stem cell regeneration
title_sort recent updates on phthalate exposure and human health: a special focus on liver toxicity and stem cell regeneration
publisher Springer
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/73719/1/Recent%20updates%20on%20phthalate%20exposure%20and%20human%20health%20a%20special%20focus%20on%20liver%20toxicity%20and%20stem%20cell%20regeneration.pdf
http://psasir.upm.edu.my/id/eprint/73719/
https://link.springer.com/article/10.1007%2Fs11356-018-1652-8
_version_ 1669008828665954304
score 13.211869

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