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Protective role of Ficus deltoidea against BPA-induced impairments of the follicular development, estrous cycle, gonadotropin and sex steroid hormones level of prepubertal rats

Ficus deltoideais one of the well-known medicinal plants in Malaysia that is traditionally used by the Malay community totreat various ailments and for maintenance of female reproductive health. The objective of this study is to evaluate thepotential protective roles ofFicus deltoideaagainst BPA-ind...

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Main Authors: Mohamad Zaid, Siti Sarah, Othman, Shatrah, M. Kassim, Normadiah
Format: Article
Language:English
Published: BMC 2018
Online Access:http://psasir.upm.edu.my/id/eprint/73665/1/Protective%20role%20of%20Ficus%20deltoidea%20against%20BPA-induced%20impairments%20of%20the%20follicular%20development%2C%20estrous%20cycle%2C%20gonadotropin%20and%20sex%20steroid%20hormones%20level%20of%20prepubertal%20rats.pdf
http://psasir.upm.edu.my/id/eprint/73665/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260867/pdf/13048_2018_Article_466.pdf
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spelling my.upm.eprints.736652020-06-24T03:08:13Z http://psasir.upm.edu.my/id/eprint/73665/ Protective role of Ficus deltoidea against BPA-induced impairments of the follicular development, estrous cycle, gonadotropin and sex steroid hormones level of prepubertal rats Mohamad Zaid, Siti Sarah Othman, Shatrah M. Kassim, Normadiah Ficus deltoideais one of the well-known medicinal plants in Malaysia that is traditionally used by the Malay community totreat various ailments and for maintenance of female reproductive health. The objective of this study is to evaluate thepotential protective roles ofFicus deltoideaagainst BPA-induced toxicity of the pituitary-ovarian axis in pre-pubertal femalerats. In this study, four groups of pre-pubertal female Sprague Dawley rats were administered with the followings by oralgavage for a period of six weeks: NC (negative control- treated with vehicle), PC (positive control-treated with BPA at 10 mg/kg/BW), F (treated withFicus deltoideaat 100 mg/kg/BW, then exposed to BPA at 10 mg/kg/BW) and FC (Ficus deltoideacontrol - treated withFicus deltoideaat 100 mg/kg/BW). Daily vaginal smear, ovarian follicular development as well asgonadotropin and sexual-steroid hormone levels were determined. The findings showed thatFicus deltoideademonstratedpreventive role against BPA-induced toxicity on the ovaries. This was evident bythe increased percentage of rats withnormal estrous cycle, qualitatively reduced number of atretic follicles (as observed in histopathological examination) andnormalization of the gonadotropins hormone (FSH) and sexual steroid hormone (progesterone) levels. In conclusion,Ficusdeltoideahas the capability to prevent the effects of BPA toxicity in the hypothalamus-pituitary-gonadal axis of prepubertalfemale reproductive system, possibly due to its variety ofphytochemical properties. Therefore, these findingsstrongly support the traditional belief that this medicinal plant is beneficial as daily dietary supplement forthe maintenance of female reproductive health. BMC 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/73665/1/Protective%20role%20of%20Ficus%20deltoidea%20against%20BPA-induced%20impairments%20of%20the%20follicular%20development%2C%20estrous%20cycle%2C%20gonadotropin%20and%20sex%20steroid%20hormones%20level%20of%20prepubertal%20rats.pdf Mohamad Zaid, Siti Sarah and Othman, Shatrah and M. Kassim, Normadiah (2018) Protective role of Ficus deltoidea against BPA-induced impairments of the follicular development, estrous cycle, gonadotropin and sex steroid hormones level of prepubertal rats. Journal of Ovarian Research, 11 (1). pp. 1-9. ISSN ESSN: 1757-2215 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260867/pdf/13048_2018_Article_466.pdf 10.1186/s13048-018-0466-0
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Ficus deltoideais one of the well-known medicinal plants in Malaysia that is traditionally used by the Malay community totreat various ailments and for maintenance of female reproductive health. The objective of this study is to evaluate thepotential protective roles ofFicus deltoideaagainst BPA-induced toxicity of the pituitary-ovarian axis in pre-pubertal femalerats. In this study, four groups of pre-pubertal female Sprague Dawley rats were administered with the followings by oralgavage for a period of six weeks: NC (negative control- treated with vehicle), PC (positive control-treated with BPA at 10 mg/kg/BW), F (treated withFicus deltoideaat 100 mg/kg/BW, then exposed to BPA at 10 mg/kg/BW) and FC (Ficus deltoideacontrol - treated withFicus deltoideaat 100 mg/kg/BW). Daily vaginal smear, ovarian follicular development as well asgonadotropin and sexual-steroid hormone levels were determined. The findings showed thatFicus deltoideademonstratedpreventive role against BPA-induced toxicity on the ovaries. This was evident bythe increased percentage of rats withnormal estrous cycle, qualitatively reduced number of atretic follicles (as observed in histopathological examination) andnormalization of the gonadotropins hormone (FSH) and sexual steroid hormone (progesterone) levels. In conclusion,Ficusdeltoideahas the capability to prevent the effects of BPA toxicity in the hypothalamus-pituitary-gonadal axis of prepubertalfemale reproductive system, possibly due to its variety ofphytochemical properties. Therefore, these findingsstrongly support the traditional belief that this medicinal plant is beneficial as daily dietary supplement forthe maintenance of female reproductive health.
format Article
author Mohamad Zaid, Siti Sarah
Othman, Shatrah
M. Kassim, Normadiah
spellingShingle Mohamad Zaid, Siti Sarah
Othman, Shatrah
M. Kassim, Normadiah
Protective role of Ficus deltoidea against BPA-induced impairments of the follicular development, estrous cycle, gonadotropin and sex steroid hormones level of prepubertal rats
author_facet Mohamad Zaid, Siti Sarah
Othman, Shatrah
M. Kassim, Normadiah
author_sort Mohamad Zaid, Siti Sarah
title Protective role of Ficus deltoidea against BPA-induced impairments of the follicular development, estrous cycle, gonadotropin and sex steroid hormones level of prepubertal rats
title_short Protective role of Ficus deltoidea against BPA-induced impairments of the follicular development, estrous cycle, gonadotropin and sex steroid hormones level of prepubertal rats
title_full Protective role of Ficus deltoidea against BPA-induced impairments of the follicular development, estrous cycle, gonadotropin and sex steroid hormones level of prepubertal rats
title_fullStr Protective role of Ficus deltoidea against BPA-induced impairments of the follicular development, estrous cycle, gonadotropin and sex steroid hormones level of prepubertal rats
title_full_unstemmed Protective role of Ficus deltoidea against BPA-induced impairments of the follicular development, estrous cycle, gonadotropin and sex steroid hormones level of prepubertal rats
title_sort protective role of ficus deltoidea against bpa-induced impairments of the follicular development, estrous cycle, gonadotropin and sex steroid hormones level of prepubertal rats
publisher BMC
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/73665/1/Protective%20role%20of%20Ficus%20deltoidea%20against%20BPA-induced%20impairments%20of%20the%20follicular%20development%2C%20estrous%20cycle%2C%20gonadotropin%20and%20sex%20steroid%20hormones%20level%20of%20prepubertal%20rats.pdf
http://psasir.upm.edu.my/id/eprint/73665/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260867/pdf/13048_2018_Article_466.pdf
_version_ 1671341098011721728
score 13.211869

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