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Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients

Context: Rash and oral mucositis are major non-haematological adverse events (AEs) of docetaxel, in addition to fatigue, nausea, vomiting and diarrhoea, which restrict the use of the drug in cancer therapy. Alpha-1-acid glycoprotein (AAG) is an acute phase reactant glycoprotein and is a primary carr...

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Main Authors: Jabir, Rafid Salim, Gwo, Fuang Ho, Ahmad Annuar, Muhammad Azrif, Stanslas, Johnson
Format: Article
Language:English
Published: Taylor & Francis 2018
Online Access:http://psasir.upm.edu.my/id/eprint/73537/1/Plasma%20alpha-1-acid%20glycoprotein%20as%20a%20potential%20predictive%20biomarker%20for%20non-haematological%20adverse%20events%20of%20docetaxel%20in%20breast%20cancer%20patients.pdf
http://psasir.upm.edu.my/id/eprint/73537/
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spelling my.upm.eprints.735372020-06-08T18:50:56Z http://psasir.upm.edu.my/id/eprint/73537/ Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients Jabir, Rafid Salim Gwo, Fuang Ho Ahmad Annuar, Muhammad Azrif Stanslas, Johnson Context: Rash and oral mucositis are major non-haematological adverse events (AEs) of docetaxel, in addition to fatigue, nausea, vomiting and diarrhoea, which restrict the use of the drug in cancer therapy. Alpha-1-acid glycoprotein (AAG) is an acute phase reactant glycoprotein and is a primary carrier of docetaxel in the blood. Docetaxel has extensive binding (>98%) to plasma proteins such as AAG, lipoproteins and albumin. Objective: To study the association between plasma AAG level and non-haematological AEs of docetaxel in Malaysian breast cancer patients of three major ethnic groups (Malays, Chinese and Indians). Materials and methods: One hundred and twenty Malaysian breast cancer patients receiving docetaxel as single agent chemotherapy were investigated for AAG plasma level using enzyme-linked immunosorbent assay technique. Toxicity assessment was determined using Common Terminology Criteria of Adverse Events v4.0. The association between AAG and toxicity were then established. Results: There was interethnic variation of plasma AAG level; it was 182 ± 85 mg/dl in Chinese, 237 ± 94 mg/dl in Malays and 240 ± 83 mg/dl in Indians. It was found that low plasma levels of AAG were significantly associated with oral mucositis and rash. Conclusions: This study proposes plasma AAG as a potential predictive biomarker of docetaxel non-haematological AEs namely oral mucositis and rash. Taylor & Francis 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/73537/1/Plasma%20alpha-1-acid%20glycoprotein%20as%20a%20potential%20predictive%20biomarker%20for%20non-haematological%20adverse%20events%20of%20docetaxel%20in%20breast%20cancer%20patients.pdf Jabir, Rafid Salim and Gwo, Fuang Ho and Ahmad Annuar, Muhammad Azrif and Stanslas, Johnson (2018) Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients. Biomarkers, 23 (2). 142 - 146. ISSN 1354-750X, ESSN: 1366-5804 10.1080/1354750X.2017.1334152
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Context: Rash and oral mucositis are major non-haematological adverse events (AEs) of docetaxel, in addition to fatigue, nausea, vomiting and diarrhoea, which restrict the use of the drug in cancer therapy. Alpha-1-acid glycoprotein (AAG) is an acute phase reactant glycoprotein and is a primary carrier of docetaxel in the blood. Docetaxel has extensive binding (>98%) to plasma proteins such as AAG, lipoproteins and albumin. Objective: To study the association between plasma AAG level and non-haematological AEs of docetaxel in Malaysian breast cancer patients of three major ethnic groups (Malays, Chinese and Indians). Materials and methods: One hundred and twenty Malaysian breast cancer patients receiving docetaxel as single agent chemotherapy were investigated for AAG plasma level using enzyme-linked immunosorbent assay technique. Toxicity assessment was determined using Common Terminology Criteria of Adverse Events v4.0. The association between AAG and toxicity were then established. Results: There was interethnic variation of plasma AAG level; it was 182 ± 85 mg/dl in Chinese, 237 ± 94 mg/dl in Malays and 240 ± 83 mg/dl in Indians. It was found that low plasma levels of AAG were significantly associated with oral mucositis and rash. Conclusions: This study proposes plasma AAG as a potential predictive biomarker of docetaxel non-haematological AEs namely oral mucositis and rash.
format Article
author Jabir, Rafid Salim
Gwo, Fuang Ho
Ahmad Annuar, Muhammad Azrif
Stanslas, Johnson
spellingShingle Jabir, Rafid Salim
Gwo, Fuang Ho
Ahmad Annuar, Muhammad Azrif
Stanslas, Johnson
Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients
author_facet Jabir, Rafid Salim
Gwo, Fuang Ho
Ahmad Annuar, Muhammad Azrif
Stanslas, Johnson
author_sort Jabir, Rafid Salim
title Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients
title_short Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients
title_full Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients
title_fullStr Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients
title_full_unstemmed Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients
title_sort plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients
publisher Taylor & Francis
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/73537/1/Plasma%20alpha-1-acid%20glycoprotein%20as%20a%20potential%20predictive%20biomarker%20for%20non-haematological%20adverse%20events%20of%20docetaxel%20in%20breast%20cancer%20patients.pdf
http://psasir.upm.edu.my/id/eprint/73537/
_version_ 1669008820013105152
score 13.211869

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