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Blood fatty acid status and clinical outcomes in dialysis patients: a systematic review

Blood fatty acids (FAs) are derived from endogenous and dietary routes. Metabolic abnormalities from kidney dysfunction, as well as cross-cultural dietary habits, may alter the FA profile of dialysis patients (DP), leading to detrimental clinical outcomes. Therefore, we aimed to (i) summarize FA sta...

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Main Authors: Mat Daud, Zulfitri 'Azuan, Karuppiah, Thilakavathy, Narayanan, Sreelakshmi Sankara, Chinna, Karuthan, Abdul Gafor, Abdul Halim, Khosla, Pramod, Khor, Ban Hock, Sundram, Kalyana
Format: Article
Language:English
Published: Multidisciplinary Digital Publishing Institute (MDPI) 2018
Online Access:http://psasir.upm.edu.my/id/eprint/73291/1/BLOOD.pdf
http://psasir.upm.edu.my/id/eprint/73291/
https://pubmed.ncbi.nlm.nih.gov/30248953/
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spelling my.upm.eprints.732912020-11-30T08:32:51Z http://psasir.upm.edu.my/id/eprint/73291/ Blood fatty acid status and clinical outcomes in dialysis patients: a systematic review Mat Daud, Zulfitri 'Azuan Karuppiah, Thilakavathy Narayanan, Sreelakshmi Sankara Chinna, Karuthan Abdul Gafor, Abdul Halim Khosla, Pramod Khor, Ban Hock Sundram, Kalyana Blood fatty acids (FAs) are derived from endogenous and dietary routes. Metabolic abnormalities from kidney dysfunction, as well as cross-cultural dietary habits, may alter the FA profile of dialysis patients (DP), leading to detrimental clinical outcomes. Therefore, we aimed to (i) summarize FA status of DP from different countries, (ii) compare blood FA composition between healthy controls and DP, and (iii) evaluate FA profile and clinical endpoints in DP. Fifty-three articles from 1980 onwards, reporting FA profile in hemodialysis and peritoneal DP, were identified from PubMed, Embase, and the Cochrane library. Studies on pediatric, predialysis chronic kidney disease, acute kidney injury, and transplant patients were excluded. Moderate to high levels of n-3 polyunsaturated fatty acids (PUFA) were reported in Japan, Korea, Denmark, and Sweden. Compared to healthy adults, DP had lower proportions of n-3 and n-6 PUFA, but higher proportion of monounsaturated fatty acids. Two studies reported inverse associations between n-3 PUFAs and risks of sudden cardiac death, while one reported eicosapentaenoic acid + docosahexaenoic acid)/arachidonic acid ratio was inversely associated with cardiovascular events. The relationship between all-cause mortality and blood FA composition in DP remained inconclusive. The current evidence highlights a critical role for essential FA in nutritional management of DP. Multidisciplinary Digital Publishing Institute (MDPI) 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/73291/1/BLOOD.pdf Mat Daud, Zulfitri 'Azuan and Karuppiah, Thilakavathy and Narayanan, Sreelakshmi Sankara and Chinna, Karuthan and Abdul Gafor, Abdul Halim and Khosla, Pramod and Khor, Ban Hock and Sundram, Kalyana (2018) Blood fatty acid status and clinical outcomes in dialysis patients: a systematic review. Nutrients, 10 (10). art. no. 1353. pp. 1-21. ISSN 2072-6643 https://pubmed.ncbi.nlm.nih.gov/30248953/ 10.3390/nu10101353
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Blood fatty acids (FAs) are derived from endogenous and dietary routes. Metabolic abnormalities from kidney dysfunction, as well as cross-cultural dietary habits, may alter the FA profile of dialysis patients (DP), leading to detrimental clinical outcomes. Therefore, we aimed to (i) summarize FA status of DP from different countries, (ii) compare blood FA composition between healthy controls and DP, and (iii) evaluate FA profile and clinical endpoints in DP. Fifty-three articles from 1980 onwards, reporting FA profile in hemodialysis and peritoneal DP, were identified from PubMed, Embase, and the Cochrane library. Studies on pediatric, predialysis chronic kidney disease, acute kidney injury, and transplant patients were excluded. Moderate to high levels of n-3 polyunsaturated fatty acids (PUFA) were reported in Japan, Korea, Denmark, and Sweden. Compared to healthy adults, DP had lower proportions of n-3 and n-6 PUFA, but higher proportion of monounsaturated fatty acids. Two studies reported inverse associations between n-3 PUFAs and risks of sudden cardiac death, while one reported eicosapentaenoic acid + docosahexaenoic acid)/arachidonic acid ratio was inversely associated with cardiovascular events. The relationship between all-cause mortality and blood FA composition in DP remained inconclusive. The current evidence highlights a critical role for essential FA in nutritional management of DP.
format Article
author Mat Daud, Zulfitri 'Azuan
Karuppiah, Thilakavathy
Narayanan, Sreelakshmi Sankara
Chinna, Karuthan
Abdul Gafor, Abdul Halim
Khosla, Pramod
Khor, Ban Hock
Sundram, Kalyana
spellingShingle Mat Daud, Zulfitri 'Azuan
Karuppiah, Thilakavathy
Narayanan, Sreelakshmi Sankara
Chinna, Karuthan
Abdul Gafor, Abdul Halim
Khosla, Pramod
Khor, Ban Hock
Sundram, Kalyana
Blood fatty acid status and clinical outcomes in dialysis patients: a systematic review
author_facet Mat Daud, Zulfitri 'Azuan
Karuppiah, Thilakavathy
Narayanan, Sreelakshmi Sankara
Chinna, Karuthan
Abdul Gafor, Abdul Halim
Khosla, Pramod
Khor, Ban Hock
Sundram, Kalyana
author_sort Mat Daud, Zulfitri 'Azuan
title Blood fatty acid status and clinical outcomes in dialysis patients: a systematic review
title_short Blood fatty acid status and clinical outcomes in dialysis patients: a systematic review
title_full Blood fatty acid status and clinical outcomes in dialysis patients: a systematic review
title_fullStr Blood fatty acid status and clinical outcomes in dialysis patients: a systematic review
title_full_unstemmed Blood fatty acid status and clinical outcomes in dialysis patients: a systematic review
title_sort blood fatty acid status and clinical outcomes in dialysis patients: a systematic review
publisher Multidisciplinary Digital Publishing Institute (MDPI)
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/73291/1/BLOOD.pdf
http://psasir.upm.edu.my/id/eprint/73291/
https://pubmed.ncbi.nlm.nih.gov/30248953/
_version_ 1685580243493978112
score 13.211869

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