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A cyclic peptide inhibitor of the iNOS–SPSB protein–protein interaction as a potential anti-infective agent

SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4 interact with inducible nitric oxide synthase (iNOS), causing the iNOS to be polyubiquitinated and targeted for degradation. Inhibition of this interaction increases iNOS levels, and consequently cellular nitric oxide (NO) concent...

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Bibliographic Details
Main Authors: Mohd Shariff, Fairolniza, Sadek, Maiada M., Barlow, Nicholas, Leung, Eleanor W.W., Noonan, Billy J. Williams, Yap, Beow Keat, Davies, Tom T. Caradoc, Nicholsan, Sandra E., Chalmers, David K., Thompson, Philip E., Law, Ruby H. P., Norton, Raymond S.
Format: Article
Language:English
Published: American Chemical Society 2018
Online Access:http://psasir.upm.edu.my/id/eprint/72901/1/INOS.pdf
http://psasir.upm.edu.my/id/eprint/72901/
https://pubs.acs.org/doi/10.1021/acschembio.8b00561
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