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Graphene oxide as a nanocarrier for a theranostics delivery system of protocatechuic acid and gadolinium/gold nanoparticles

We have synthesized a graphene oxide (GO)-based theranostic nanodelivery system (GOTS) for magnetic resonance imaging (MRI) using naturally occurring protocatechuic acid (PA) as an anticancer agent and gadolinium (III) nitrate hexahydrate (Gd) as the starting material for a contrast agent,. Gold nan...

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Main Authors: Usman, Muhammad Sani, Hussein, Mohd Zobir, Kura, Aminu Umar, Fakurazi, Sharida, Masarudin, Mas Jaffri, Ahmad Saad, Fathinul Fikri
Format: Article
Language:English
Published: MDPI 2018
Online Access:http://psasir.upm.edu.my/id/eprint/72860/1/Graphene%20oxide%20as%20a%20nanocarrier%20.pdf
http://psasir.upm.edu.my/id/eprint/72860/
https://v2.sherpa.ac.uk/id/publication/19458
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spelling my.upm.eprints.728602021-03-25T21:48:32Z http://psasir.upm.edu.my/id/eprint/72860/ Graphene oxide as a nanocarrier for a theranostics delivery system of protocatechuic acid and gadolinium/gold nanoparticles Usman, Muhammad Sani Hussein, Mohd Zobir Kura, Aminu Umar Fakurazi, Sharida Masarudin, Mas Jaffri Ahmad Saad, Fathinul Fikri We have synthesized a graphene oxide (GO)-based theranostic nanodelivery system (GOTS) for magnetic resonance imaging (MRI) using naturally occurring protocatechuic acid (PA) as an anticancer agent and gadolinium (III) nitrate hexahydrate (Gd) as the starting material for a contrast agent,. Gold nanoparticles (AuNPs) were subsequently used as second diagnostic agent. The GO nanosheets were first prepared from graphite via the improved Hummer’s protocol. The conjugation of the GO and the PA was done via hydrogen bonding and π–π stacking interactions, followed by surface adsorption of the AuNPs through electrostatic interactions. GAGPA is the name given to the nanocomposite obtained from Gd and PA conjugation. However, after coating with AuNPs, the name was modified to GAGPAu. The physicochemical properties of the GAGPA and GAGPAu nanohybrids were studied using various characterization techniques. The results from the analyses confirmed the formation of the GOTS. The powder X-ray diffraction (PXRD) results showed the diffractive patterns for pure GO nanolayers, which changed after subsequent conjugation of the Gd and PA. The AuNPs patterns were also recorded after surface adsorption. Cytotoxicity and magnetic resonance imaging (MRI) contrast tests were also carried out on the developed GOTS. The GAGPAu was significantly cytotoxic to the human liver hepatocellular carcinoma cell line (HepG2) but nontoxic to the standard fibroblast cell line (3T3). The GAGPAu also appeared to possess higher T1 contrast compared to the pure Gd and water reference. The GOTS has good prospects of serving as future theranostic platform for cancer chemotherapy and diagnosis. MDPI 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72860/1/Graphene%20oxide%20as%20a%20nanocarrier%20.pdf Usman, Muhammad Sani and Hussein, Mohd Zobir and Kura, Aminu Umar and Fakurazi, Sharida and Masarudin, Mas Jaffri and Ahmad Saad, Fathinul Fikri (2018) Graphene oxide as a nanocarrier for a theranostics delivery system of protocatechuic acid and gadolinium/gold nanoparticles. Molecules, 23 (2). pp. 1-16. ISSN 1420-3049 https://v2.sherpa.ac.uk/id/publication/19458 10.3390/molecules23020500
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description We have synthesized a graphene oxide (GO)-based theranostic nanodelivery system (GOTS) for magnetic resonance imaging (MRI) using naturally occurring protocatechuic acid (PA) as an anticancer agent and gadolinium (III) nitrate hexahydrate (Gd) as the starting material for a contrast agent,. Gold nanoparticles (AuNPs) were subsequently used as second diagnostic agent. The GO nanosheets were first prepared from graphite via the improved Hummer’s protocol. The conjugation of the GO and the PA was done via hydrogen bonding and π–π stacking interactions, followed by surface adsorption of the AuNPs through electrostatic interactions. GAGPA is the name given to the nanocomposite obtained from Gd and PA conjugation. However, after coating with AuNPs, the name was modified to GAGPAu. The physicochemical properties of the GAGPA and GAGPAu nanohybrids were studied using various characterization techniques. The results from the analyses confirmed the formation of the GOTS. The powder X-ray diffraction (PXRD) results showed the diffractive patterns for pure GO nanolayers, which changed after subsequent conjugation of the Gd and PA. The AuNPs patterns were also recorded after surface adsorption. Cytotoxicity and magnetic resonance imaging (MRI) contrast tests were also carried out on the developed GOTS. The GAGPAu was significantly cytotoxic to the human liver hepatocellular carcinoma cell line (HepG2) but nontoxic to the standard fibroblast cell line (3T3). The GAGPAu also appeared to possess higher T1 contrast compared to the pure Gd and water reference. The GOTS has good prospects of serving as future theranostic platform for cancer chemotherapy and diagnosis.
format Article
author Usman, Muhammad Sani
Hussein, Mohd Zobir
Kura, Aminu Umar
Fakurazi, Sharida
Masarudin, Mas Jaffri
Ahmad Saad, Fathinul Fikri
spellingShingle Usman, Muhammad Sani
Hussein, Mohd Zobir
Kura, Aminu Umar
Fakurazi, Sharida
Masarudin, Mas Jaffri
Ahmad Saad, Fathinul Fikri
Graphene oxide as a nanocarrier for a theranostics delivery system of protocatechuic acid and gadolinium/gold nanoparticles
author_facet Usman, Muhammad Sani
Hussein, Mohd Zobir
Kura, Aminu Umar
Fakurazi, Sharida
Masarudin, Mas Jaffri
Ahmad Saad, Fathinul Fikri
author_sort Usman, Muhammad Sani
title Graphene oxide as a nanocarrier for a theranostics delivery system of protocatechuic acid and gadolinium/gold nanoparticles
title_short Graphene oxide as a nanocarrier for a theranostics delivery system of protocatechuic acid and gadolinium/gold nanoparticles
title_full Graphene oxide as a nanocarrier for a theranostics delivery system of protocatechuic acid and gadolinium/gold nanoparticles
title_fullStr Graphene oxide as a nanocarrier for a theranostics delivery system of protocatechuic acid and gadolinium/gold nanoparticles
title_full_unstemmed Graphene oxide as a nanocarrier for a theranostics delivery system of protocatechuic acid and gadolinium/gold nanoparticles
title_sort graphene oxide as a nanocarrier for a theranostics delivery system of protocatechuic acid and gadolinium/gold nanoparticles
publisher MDPI
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/72860/1/Graphene%20oxide%20as%20a%20nanocarrier%20.pdf
http://psasir.upm.edu.my/id/eprint/72860/
https://v2.sherpa.ac.uk/id/publication/19458
_version_ 1695532767177080832
score 13.211869

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