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Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies

A variety of imine derivatives have been synthesized via Suzuki cross coupling of N-(4-bromophenyl)-1-(3-bromothiophen-2-yl)methanimine with various arylboronic acids in moderate to good yields (58–72%). A wide range of electron donating and withdrawing functional groups were well tolerated in react...

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Main Authors: Rizwan, Komal, Rasool, Nasir, Rehman, Ravya, Mahmood, Tariq, Ayub, Khurshid, Rasheed, Tahir, Ahmad, Gulraiz, Malik, Ayesha, Khan, Shakeel Ahmad, Akhtar, Muhammad Nadeem, Mohammed Alitheen, Noorjahan Banu, Aziz, Muhammad Nazirul Mubin
Format: Article
Language:English
Published: SpringerOpen 2018
Online Access:http://psasir.upm.edu.my/id/eprint/72707/1/Facile%20synthesis.pdf
http://psasir.upm.edu.my/id/eprint/72707/
https://link.springer.com/article/10.1186/s13065-018-0451-0
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spelling my.upm.eprints.727072021-01-27T15:35:20Z http://psasir.upm.edu.my/id/eprint/72707/ Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies Rizwan, Komal Rasool, Nasir Rehman, Ravya Mahmood, Tariq Ayub, Khurshid Rasheed, Tahir Ahmad, Gulraiz Malik, Ayesha Khan, Shakeel Ahmad Akhtar, Muhammad Nadeem Mohammed Alitheen, Noorjahan Banu Aziz, Muhammad Nazirul Mubin A variety of imine derivatives have been synthesized via Suzuki cross coupling of N-(4-bromophenyl)-1-(3-bromothiophen-2-yl)methanimine with various arylboronic acids in moderate to good yields (58–72%). A wide range of electron donating and withdrawing functional groups were well tolerated in reaction conditions. To explore the structural properties, Density functional theory (DFT) investigations on all synthesized molecules (3a–3i) were performed. Conceptual DFT reactivity descriptors and molecular electrostatic potential analyses were performed by using B3LYP/6-31G(d,p) method to explore the reactivity and reacting sites of all derivatives (3a–3i). SpringerOpen 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72707/1/Facile%20synthesis.pdf Rizwan, Komal and Rasool, Nasir and Rehman, Ravya and Mahmood, Tariq and Ayub, Khurshid and Rasheed, Tahir and Ahmad, Gulraiz and Malik, Ayesha and Khan, Shakeel Ahmad and Akhtar, Muhammad Nadeem and Mohammed Alitheen, Noorjahan Banu and Aziz, Muhammad Nazirul Mubin (2018) Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies. Chemistry Central Journal, 12 (1). art. no. 84. pp. 1-9. ISSN 1752-153X https://link.springer.com/article/10.1186/s13065-018-0451-0 10.1186/s13065-018-0451-0
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description A variety of imine derivatives have been synthesized via Suzuki cross coupling of N-(4-bromophenyl)-1-(3-bromothiophen-2-yl)methanimine with various arylboronic acids in moderate to good yields (58–72%). A wide range of electron donating and withdrawing functional groups were well tolerated in reaction conditions. To explore the structural properties, Density functional theory (DFT) investigations on all synthesized molecules (3a–3i) were performed. Conceptual DFT reactivity descriptors and molecular electrostatic potential analyses were performed by using B3LYP/6-31G(d,p) method to explore the reactivity and reacting sites of all derivatives (3a–3i).
format Article
author Rizwan, Komal
Rasool, Nasir
Rehman, Ravya
Mahmood, Tariq
Ayub, Khurshid
Rasheed, Tahir
Ahmad, Gulraiz
Malik, Ayesha
Khan, Shakeel Ahmad
Akhtar, Muhammad Nadeem
Mohammed Alitheen, Noorjahan Banu
Aziz, Muhammad Nazirul Mubin
spellingShingle Rizwan, Komal
Rasool, Nasir
Rehman, Ravya
Mahmood, Tariq
Ayub, Khurshid
Rasheed, Tahir
Ahmad, Gulraiz
Malik, Ayesha
Khan, Shakeel Ahmad
Akhtar, Muhammad Nadeem
Mohammed Alitheen, Noorjahan Banu
Aziz, Muhammad Nazirul Mubin
Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies
author_facet Rizwan, Komal
Rasool, Nasir
Rehman, Ravya
Mahmood, Tariq
Ayub, Khurshid
Rasheed, Tahir
Ahmad, Gulraiz
Malik, Ayesha
Khan, Shakeel Ahmad
Akhtar, Muhammad Nadeem
Mohammed Alitheen, Noorjahan Banu
Aziz, Muhammad Nazirul Mubin
author_sort Rizwan, Komal
title Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies
title_short Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies
title_full Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies
title_fullStr Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies
title_full_unstemmed Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies
title_sort facile synthesis of n- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via suzuki cross-coupling reaction: their characterization and dft studies
publisher SpringerOpen
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/72707/1/Facile%20synthesis.pdf
http://psasir.upm.edu.my/id/eprint/72707/
https://link.springer.com/article/10.1186/s13065-018-0451-0
_version_ 1690372563983663104
score 13.211869

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