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Fabrication, characterization and cytotoxicity of spherical-shaped conjugated gold-cockle shell derived calcium carbonate nanoparticles for biomedical applications

The evolution of nanomaterial in science has brought about a growing increase in nanotechnology, biomedicine, and engineering fields. This study was aimed at fabrication and characterization of conjugated gold-cockle shell-derived calcium carbonate nanoparticles (Au-CSCaCO3NPs) for biomedical applic...

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Main Authors: Kiranda, Hanan Karimah, Mahmud, Rozi, Abubakar, Danmaigoro, Abu Bakar @ Zakaria, Md Zuki
Format: Article
Language:English
Published: SpringerOpen 2018
Online Access:http://psasir.upm.edu.my/id/eprint/72702/1/Fabrication.pdf
http://psasir.upm.edu.my/id/eprint/72702/
https://nanoscalereslett.springeropen.com/articles/10.1186/s11671-017-2411-3
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spelling my.upm.eprints.727022021-01-11T09:19:10Z http://psasir.upm.edu.my/id/eprint/72702/ Fabrication, characterization and cytotoxicity of spherical-shaped conjugated gold-cockle shell derived calcium carbonate nanoparticles for biomedical applications Kiranda, Hanan Karimah Mahmud, Rozi Abubakar, Danmaigoro Abu Bakar @ Zakaria, Md Zuki The evolution of nanomaterial in science has brought about a growing increase in nanotechnology, biomedicine, and engineering fields. This study was aimed at fabrication and characterization of conjugated gold-cockle shell-derived calcium carbonate nanoparticles (Au-CSCaCO3NPs) for biomedical application. The synthetic technique employed used gold nanoparticle citrate reduction method and a simple precipitation method coupled with mechanical use of a Programmable roller-ball mill. The synthesized conjugated nanomaterial was characterized for its physicochemical properties using transmission electron microscope (TEM), field emission scanning electron microscope (FESEM) equipped with energy dispersive X-ray (EDX) and Fourier transform infrared spectroscopy (FTIR). However, the intricacy of cellular mechanisms can prove challenging for nanomaterial like Au-CSCaCO3NPs and thus, the need for cytotoxicity assessment. The obtained spherical-shaped nanoparticles (light-green purplish) have an average diameter size of 35 ± 16 nm, high carbon and oxygen composition. The conjugated nanomaterial, also possesses a unique spectra for aragonite polymorph and carboxylic bond significantly supporting interactions between conjugated nanoparticles. The negative surface charge and spectra absorbance highlighted their stability. The resultant spherical shaped conjugated Au-CSCaCO3NPs could be a great nanomaterial for biomedical applications. SpringerOpen 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72702/1/Fabrication.pdf Kiranda, Hanan Karimah and Mahmud, Rozi and Abubakar, Danmaigoro and Abu Bakar @ Zakaria, Md Zuki (2018) Fabrication, characterization and cytotoxicity of spherical-shaped conjugated gold-cockle shell derived calcium carbonate nanoparticles for biomedical applications. Nanoscale Research Letters, 13 (1). pp. 1-10. ISSN 1556-276X https://nanoscalereslett.springeropen.com/articles/10.1186/s11671-017-2411-3 10.1186/s11671-017-2411-3
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The evolution of nanomaterial in science has brought about a growing increase in nanotechnology, biomedicine, and engineering fields. This study was aimed at fabrication and characterization of conjugated gold-cockle shell-derived calcium carbonate nanoparticles (Au-CSCaCO3NPs) for biomedical application. The synthetic technique employed used gold nanoparticle citrate reduction method and a simple precipitation method coupled with mechanical use of a Programmable roller-ball mill. The synthesized conjugated nanomaterial was characterized for its physicochemical properties using transmission electron microscope (TEM), field emission scanning electron microscope (FESEM) equipped with energy dispersive X-ray (EDX) and Fourier transform infrared spectroscopy (FTIR). However, the intricacy of cellular mechanisms can prove challenging for nanomaterial like Au-CSCaCO3NPs and thus, the need for cytotoxicity assessment. The obtained spherical-shaped nanoparticles (light-green purplish) have an average diameter size of 35 ± 16 nm, high carbon and oxygen composition. The conjugated nanomaterial, also possesses a unique spectra for aragonite polymorph and carboxylic bond significantly supporting interactions between conjugated nanoparticles. The negative surface charge and spectra absorbance highlighted their stability. The resultant spherical shaped conjugated Au-CSCaCO3NPs could be a great nanomaterial for biomedical applications.
format Article
author Kiranda, Hanan Karimah
Mahmud, Rozi
Abubakar, Danmaigoro
Abu Bakar @ Zakaria, Md Zuki
spellingShingle Kiranda, Hanan Karimah
Mahmud, Rozi
Abubakar, Danmaigoro
Abu Bakar @ Zakaria, Md Zuki
Fabrication, characterization and cytotoxicity of spherical-shaped conjugated gold-cockle shell derived calcium carbonate nanoparticles for biomedical applications
author_facet Kiranda, Hanan Karimah
Mahmud, Rozi
Abubakar, Danmaigoro
Abu Bakar @ Zakaria, Md Zuki
author_sort Kiranda, Hanan Karimah
title Fabrication, characterization and cytotoxicity of spherical-shaped conjugated gold-cockle shell derived calcium carbonate nanoparticles for biomedical applications
title_short Fabrication, characterization and cytotoxicity of spherical-shaped conjugated gold-cockle shell derived calcium carbonate nanoparticles for biomedical applications
title_full Fabrication, characterization and cytotoxicity of spherical-shaped conjugated gold-cockle shell derived calcium carbonate nanoparticles for biomedical applications
title_fullStr Fabrication, characterization and cytotoxicity of spherical-shaped conjugated gold-cockle shell derived calcium carbonate nanoparticles for biomedical applications
title_full_unstemmed Fabrication, characterization and cytotoxicity of spherical-shaped conjugated gold-cockle shell derived calcium carbonate nanoparticles for biomedical applications
title_sort fabrication, characterization and cytotoxicity of spherical-shaped conjugated gold-cockle shell derived calcium carbonate nanoparticles for biomedical applications
publisher SpringerOpen
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/72702/1/Fabrication.pdf
http://psasir.upm.edu.my/id/eprint/72702/
https://nanoscalereslett.springeropen.com/articles/10.1186/s11671-017-2411-3
_version_ 1688648275375161344
score 13.211869

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