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Early life secondhand smoke exposure assessed by hair nicotine biomarker may reduce children's neurodevelopment at 2 years of age

Exposure to secondhand smoke (SHS) can affect fetal brain development as well as subsequent neurodevelopment. This study aimed to determine the association between prenatal and postnatal SHS exposure with children's neurodevelopment at 2 years of age. Among 107 mother-child pairs from a Malaysi...

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Main Authors: Mohamed, Nur Nadia, Loy, See Ling, Lim, Poh Ying, Al Mamun, Abdullah, Jan Mohamed, Hamid Jan
Format: Article
Language:English
Published: Elsevier 2018
Online Access:http://psasir.upm.edu.my/id/eprint/72356/1/Early%20life%20secondhand%20smoke%20exposure%20assessed%20by%20hair%20nicotine%20biomarker%20.pdf
http://psasir.upm.edu.my/id/eprint/72356/
https://www.sciencedirect.com/science/article/pii/S0048969717320284
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spelling my.upm.eprints.723562020-05-19T02:52:11Z http://psasir.upm.edu.my/id/eprint/72356/ Early life secondhand smoke exposure assessed by hair nicotine biomarker may reduce children's neurodevelopment at 2 years of age Mohamed, Nur Nadia Loy, See Ling Lim, Poh Ying Al Mamun, Abdullah Jan Mohamed, Hamid Jan Exposure to secondhand smoke (SHS) can affect fetal brain development as well as subsequent neurodevelopment. This study aimed to determine the association between prenatal and postnatal SHS exposure with children's neurodevelopment at 2 years of age. Among 107 mother-child pairs from a Malaysia prospective cohort, prenatal and postnatal SHS exposure was determined based on maternal and child hair nicotine concentrations. Multiple linear regressions were used to determine the association between prenatal and postnatal levels of nicotine in maternal and children's' hair with children's neurodevelopment. After adjustment for confounders, prenatal nicotine concentration levels were negatively associated with communication (β = − 2.059; p = 0.015) and fine motor skills (β = − 2.120; p = 0.002) while postnatal nicotine concentration levels were inversely associated with fine motors (β = − 0.124; p = 0.004) and problem solving skills (β = − 0.117; p = 0.013). In conclusion, this study suggests that early life exposure to SHS may affect children's neurodevelopment. Elsevier 2018-01 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72356/1/Early%20life%20secondhand%20smoke%20exposure%20assessed%20by%20hair%20nicotine%20biomarker%20.pdf Mohamed, Nur Nadia and Loy, See Ling and Lim, Poh Ying and Al Mamun, Abdullah and Jan Mohamed, Hamid Jan (2018) Early life secondhand smoke exposure assessed by hair nicotine biomarker may reduce children's neurodevelopment at 2 years of age. Science of the Total Environment, 610-611. 147 - 153. ISSN 0048-9697; ESSN: 1879-1026 https://www.sciencedirect.com/science/article/pii/S0048969717320284 10.1016/j.scitotenv.2017.08.030
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Exposure to secondhand smoke (SHS) can affect fetal brain development as well as subsequent neurodevelopment. This study aimed to determine the association between prenatal and postnatal SHS exposure with children's neurodevelopment at 2 years of age. Among 107 mother-child pairs from a Malaysia prospective cohort, prenatal and postnatal SHS exposure was determined based on maternal and child hair nicotine concentrations. Multiple linear regressions were used to determine the association between prenatal and postnatal levels of nicotine in maternal and children's' hair with children's neurodevelopment. After adjustment for confounders, prenatal nicotine concentration levels were negatively associated with communication (β = − 2.059; p = 0.015) and fine motor skills (β = − 2.120; p = 0.002) while postnatal nicotine concentration levels were inversely associated with fine motors (β = − 0.124; p = 0.004) and problem solving skills (β = − 0.117; p = 0.013). In conclusion, this study suggests that early life exposure to SHS may affect children's neurodevelopment.
format Article
author Mohamed, Nur Nadia
Loy, See Ling
Lim, Poh Ying
Al Mamun, Abdullah
Jan Mohamed, Hamid Jan
spellingShingle Mohamed, Nur Nadia
Loy, See Ling
Lim, Poh Ying
Al Mamun, Abdullah
Jan Mohamed, Hamid Jan
Early life secondhand smoke exposure assessed by hair nicotine biomarker may reduce children's neurodevelopment at 2 years of age
author_facet Mohamed, Nur Nadia
Loy, See Ling
Lim, Poh Ying
Al Mamun, Abdullah
Jan Mohamed, Hamid Jan
author_sort Mohamed, Nur Nadia
title Early life secondhand smoke exposure assessed by hair nicotine biomarker may reduce children's neurodevelopment at 2 years of age
title_short Early life secondhand smoke exposure assessed by hair nicotine biomarker may reduce children's neurodevelopment at 2 years of age
title_full Early life secondhand smoke exposure assessed by hair nicotine biomarker may reduce children's neurodevelopment at 2 years of age
title_fullStr Early life secondhand smoke exposure assessed by hair nicotine biomarker may reduce children's neurodevelopment at 2 years of age
title_full_unstemmed Early life secondhand smoke exposure assessed by hair nicotine biomarker may reduce children's neurodevelopment at 2 years of age
title_sort early life secondhand smoke exposure assessed by hair nicotine biomarker may reduce children's neurodevelopment at 2 years of age
publisher Elsevier
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/72356/1/Early%20life%20secondhand%20smoke%20exposure%20assessed%20by%20hair%20nicotine%20biomarker%20.pdf
http://psasir.upm.edu.my/id/eprint/72356/
https://www.sciencedirect.com/science/article/pii/S0048969717320284
_version_ 1669008809748594688
score 13.222552

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