Staff View: Crystal structure and functional analysis of human C1ORF123

Crystal structure and functional analysis of human C1ORF123

Proteins of the DUF866 superfamily are exclusively found in eukaryotic cells. A member of the DUF866 superfamily, C1ORF123, is a human protein found in the open reading frame 123 of chromosome 1. The physiological role of C1ORF123 is yet to be determined. The only available protein structure of the...

Full description

Saved in:

Bibliographic Details
Main Authors:	A. Rahaman, Siti Nurulnabila, Mat Yusop, Jastina, Mohamed Hussein, Zeti Azura, Wan Kamaruddin, Wan Mohd Aizat, Ho, Kok Lian, Teh, Aik Hong, Waterman, Jitka, Tan, Boon Keat, Tan, Hwei Ling, Li, Adelicia Yongling, Chen, Ee Sin, Ng, Chyan Leong
Format:	Article
Language:	English
Published:	PeerJ 2018
Online Access:	http://psasir.upm.edu.my/id/eprint/72149/1/Crystal%20structure%20and%20functional%20analysis.pdf http://psasir.upm.edu.my/id/eprint/72149/ https://peerj.com/articles/5377/#
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my.upm.eprints.72149
record_format	eprints
spelling	my.upm.eprints.721492020-03-04T07:45:43Z http://psasir.upm.edu.my/id/eprint/72149/ Crystal structure and functional analysis of human C1ORF123 A. Rahaman, Siti Nurulnabila Mat Yusop, Jastina Mohamed Hussein, Zeti Azura Wan Kamaruddin, Wan Mohd Aizat Ho, Kok Lian Teh, Aik Hong Waterman, Jitka Tan, Boon Keat Tan, Hwei Ling Li, Adelicia Yongling Chen, Ee Sin Ng, Chyan Leong Proteins of the DUF866 superfamily are exclusively found in eukaryotic cells. A member of the DUF866 superfamily, C1ORF123, is a human protein found in the open reading frame 123 of chromosome 1. The physiological role of C1ORF123 is yet to be determined. The only available protein structure of the DUF866 family shares just 26% sequence similarity and does not contain a zinc binding motif. Here, we present the crystal structure of the recombinant human C1ORF123 protein (rC1ORF123). The structure has a 2-fold internal symmetry dividing the monomeric protein into two mirrored halves that comprise of distinct electrostatic potential. The N-terminal half of rC1ORF123 includes a zinc-binding domain interacting with a zinc ion near to a potential ligand binding cavity. Functional studies of human C1ORF123 and its homologue in the fission yeast Schizosaccharomyces pombe (SpEss1) point to a role of DUF866 protein in mitochondrial oxidative phosphorylation. PeerJ 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72149/1/Crystal%20structure%20and%20functional%20analysis.pdf A. Rahaman, Siti Nurulnabila and Mat Yusop, Jastina and Mohamed Hussein, Zeti Azura and Wan Kamaruddin, Wan Mohd Aizat and Ho, Kok Lian and Teh, Aik Hong and Waterman, Jitka and Tan, Boon Keat and Tan, Hwei Ling and Li, Adelicia Yongling and Chen, Ee Sin and Ng, Chyan Leong (2018) Crystal structure and functional analysis of human C1ORF123. PeerJ, 6. pp. 1-25. ISSN 2167-8359 https://peerj.com/articles/5377/# 10.7717/peerj.5377
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
language	English
description	Proteins of the DUF866 superfamily are exclusively found in eukaryotic cells. A member of the DUF866 superfamily, C1ORF123, is a human protein found in the open reading frame 123 of chromosome 1. The physiological role of C1ORF123 is yet to be determined. The only available protein structure of the DUF866 family shares just 26% sequence similarity and does not contain a zinc binding motif. Here, we present the crystal structure of the recombinant human C1ORF123 protein (rC1ORF123). The structure has a 2-fold internal symmetry dividing the monomeric protein into two mirrored halves that comprise of distinct electrostatic potential. The N-terminal half of rC1ORF123 includes a zinc-binding domain interacting with a zinc ion near to a potential ligand binding cavity. Functional studies of human C1ORF123 and its homologue in the fission yeast Schizosaccharomyces pombe (SpEss1) point to a role of DUF866 protein in mitochondrial oxidative phosphorylation.
format	Article
author	A. Rahaman, Siti Nurulnabila Mat Yusop, Jastina Mohamed Hussein, Zeti Azura Wan Kamaruddin, Wan Mohd Aizat Ho, Kok Lian Teh, Aik Hong Waterman, Jitka Tan, Boon Keat Tan, Hwei Ling Li, Adelicia Yongling Chen, Ee Sin Ng, Chyan Leong
spellingShingle	A. Rahaman, Siti Nurulnabila Mat Yusop, Jastina Mohamed Hussein, Zeti Azura Wan Kamaruddin, Wan Mohd Aizat Ho, Kok Lian Teh, Aik Hong Waterman, Jitka Tan, Boon Keat Tan, Hwei Ling Li, Adelicia Yongling Chen, Ee Sin Ng, Chyan Leong Crystal structure and functional analysis of human C1ORF123
author_facet	A. Rahaman, Siti Nurulnabila Mat Yusop, Jastina Mohamed Hussein, Zeti Azura Wan Kamaruddin, Wan Mohd Aizat Ho, Kok Lian Teh, Aik Hong Waterman, Jitka Tan, Boon Keat Tan, Hwei Ling Li, Adelicia Yongling Chen, Ee Sin Ng, Chyan Leong
author_sort	A. Rahaman, Siti Nurulnabila
title	Crystal structure and functional analysis of human C1ORF123
title_short	Crystal structure and functional analysis of human C1ORF123
title_full	Crystal structure and functional analysis of human C1ORF123
title_fullStr	Crystal structure and functional analysis of human C1ORF123
title_full_unstemmed	Crystal structure and functional analysis of human C1ORF123
title_sort	crystal structure and functional analysis of human c1orf123
publisher	PeerJ
publishDate	2018
url	http://psasir.upm.edu.my/id/eprint/72149/1/Crystal%20structure%20and%20functional%20analysis.pdf http://psasir.upm.edu.my/id/eprint/72149/ https://peerj.com/articles/5377/#
_version_	1662756480924778496
score	13.211869

Crystal structure and functional analysis of human C1ORF123

Similar Items