Influence of Environment and Genetics on Reproductive Health of Twins
Reproductive health is a dynamic part of our lives with a broad spectrum of events. Study of twins can assist to investigate the relationship between environmental and hereditary causes of reproductive diseases, which would otherwise be difficult if not impossible to study. High concordance betwe...
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| Format: | Thesis |
| Language: | English English |
| Published: |
2007
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| Online Access: | http://psasir.upm.edu.my/id/eprint/7159/1/FPSK%28M%29_2009_3a.pdf http://psasir.upm.edu.my/id/eprint/7159/ |
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| Summary: | Reproductive health is a dynamic part of our lives with a broad spectrum of events.
Study of twins can assist to investigate the relationship between environmental and
hereditary causes of reproductive diseases, which would otherwise be difficult if not
impossible to study. High concordance between twin pairs suggests a strong influence
for genetic factors, whereas low concordance indicates a weak influence. Preventive
measures can be taken into consideration for those who are at risk of environmental
influences if and only when the role of genetic is minor even though gene therapy may
minimize the occurrence of genetic disease.
This cross-sectional descriptive study of reproductive health of twins investigated the
heritability of qualitative and quantitative measured variables related to reproductive
events or behavior of adult twins. Subjects included 156 identical and 110 non-identical
twins, 15 years and above who were living in urban areas of Iran and Malaysia. Basic
and modern genetic analysis was adopted. Maximum likelihood analysis and model fitting analysis suggested that birth weight, weight, height, age of menarche,
premenstrual symptoms, acne, hirsutism, baldness and infertility are mostly determined
by genetic factors while characteristics of menstruation were more likely under the
influence of environmental factors. Classical genetic analysis using Falconer’s formula
suggested higher similarity between monozygotic twins than dyzyotics in relation to
reproductive behaviors such as age of first pregnancy and number of pregnancies.
Probandwise concordance rate analysis showed higher similarity between identical twins
in adopting correct reproductive behavior such as undergoing pap smear and using
family planning techniques. Model fitting analysis for the ACE model supported these
findings.
Same-sex twins had a higher risk of congenital abnormality, gynecological problem, and
irregular menstruation than opposite sex twins. Other reproductive events were not
found to be significantly different between the two groups indicating that hormonal
transition from male to female may not be a valid explanation for reproductive ill health.
Birth weight was not found to affect reproductive morbidity during adult life as
frequency of reproductive event was found to be higher among low birth weight twins
compared with normal weight twins. This finding is not consistent with fetal origin
hypothesis or thrifty gene hypothesis.
Reproductive ill-health influenced by environmental factors may be minimized using
careful primary care evaluation, early detection and prevention while genetic predisposition can be monitored for those variables under genetic influence. Early
reproductive health consultation for adolescents is recommended to avoid complications
of reproductive ill-health. |
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