Staff View: Occurrence of Chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths

Occurrence of Chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths

This study aims to determine the occurrence of C. trachomatis infection across a multi-ethnic cohort of pregnant women who presented with preterm complications and stillbirths and to determine the risk factors for C. trachomatis infection. This study also detects C. trachomatis using nested PCR and...

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Main Author:	Sulaiman, Nurshahira
Format:	Thesis
Language:	English
Published:	2012
Subjects:	Chlamydia trachomatis - isolation & purification Chlamydia trachomatis - pathogenicity Stillbirth - epidemiology - Malaysia
Online Access:	http://psasir.upm.edu.my/id/eprint/71500/1/FPSK%28M%29%202012%2044%20IR.pdf http://psasir.upm.edu.my/id/eprint/71500/
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spelling	my.upm.eprints.715002019-11-21T06:53:36Z http://psasir.upm.edu.my/id/eprint/71500/ Occurrence of Chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths Sulaiman, Nurshahira This study aims to determine the occurrence of C. trachomatis infection across a multi-ethnic cohort of pregnant women who presented with preterm complications and stillbirths and to determine the risk factors for C. trachomatis infection. This study also detects C. trachomatis using nested PCR and PCR ELISA as the screening tools. A cross-sectional study on pregnant women less than 37 weeks of pregnancy who presented with preterm contractions, preterm premature rupture of membranes and stillbirths was carried out in two public hospitals in Southern Selangor, Malaysia. A total of 106 endocervical swabs obtained were subjected to DNA amplification using Nested PCR (BioSewoom, Korea) and PCR-ELISA (Roche, USA) for C. trachomatis detection.Self-administered questionnaires were used to collect data on demographic and behavioural factors. In addition, C. trachomatis was detected in 43% of women with preterm complications and in 62% of women with stillbirths. Multiple logistic regression analysis indicated that mothers who were less than 25 years old of age (OR 2.731; 95% CI: 1.139, 6.549) and Chinese ethnicity (OR 17.799; 95% CI: 1.406, 225.387) were significant independent risk factors for chlamydial infection (p<0.05). High prevalence of C. trachomatis infection was observed among women with preterm complications and stillbirths. This study supports the essential need to screen pregnant women with preterm complications and stillbirths for infection with C. trachomatis using highly sensitive PCR ELISA. Thus, early intervention such as antibiotic therapy can be instituted at the earliest possible time with appropriate screening guidelines to reduce the adverse outcomes of C. trachomatis infection. 2012-09 Thesis NonPeerReviewed text en http://psasir.upm.edu.my/id/eprint/71500/1/FPSK%28M%29%202012%2044%20IR.pdf Sulaiman, Nurshahira (2012) Occurrence of Chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths. Masters thesis, Universiti Putra Malaysia. Chlamydia trachomatis - isolation & purification Chlamydia trachomatis - pathogenicity Stillbirth - epidemiology - Malaysia
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
language	English
topic	Chlamydia trachomatis - isolation & purification Chlamydia trachomatis - pathogenicity Stillbirth - epidemiology - Malaysia
spellingShingle	Chlamydia trachomatis - isolation & purification Chlamydia trachomatis - pathogenicity Stillbirth - epidemiology - Malaysia Sulaiman, Nurshahira Occurrence of Chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths
description	This study aims to determine the occurrence of C. trachomatis infection across a multi-ethnic cohort of pregnant women who presented with preterm complications and stillbirths and to determine the risk factors for C. trachomatis infection. This study also detects C. trachomatis using nested PCR and PCR ELISA as the screening tools. A cross-sectional study on pregnant women less than 37 weeks of pregnancy who presented with preterm contractions, preterm premature rupture of membranes and stillbirths was carried out in two public hospitals in Southern Selangor, Malaysia. A total of 106 endocervical swabs obtained were subjected to DNA amplification using Nested PCR (BioSewoom, Korea) and PCR-ELISA (Roche, USA) for C. trachomatis detection.Self-administered questionnaires were used to collect data on demographic and behavioural factors. In addition, C. trachomatis was detected in 43% of women with preterm complications and in 62% of women with stillbirths. Multiple logistic regression analysis indicated that mothers who were less than 25 years old of age (OR 2.731; 95% CI: 1.139, 6.549) and Chinese ethnicity (OR 17.799; 95% CI: 1.406, 225.387) were significant independent risk factors for chlamydial infection (p<0.05). High prevalence of C. trachomatis infection was observed among women with preterm complications and stillbirths. This study supports the essential need to screen pregnant women with preterm complications and stillbirths for infection with C. trachomatis using highly sensitive PCR ELISA. Thus, early intervention such as antibiotic therapy can be instituted at the earliest possible time with appropriate screening guidelines to reduce the adverse outcomes of C. trachomatis infection.
format	Thesis
author	Sulaiman, Nurshahira
author_facet	Sulaiman, Nurshahira
author_sort	Sulaiman, Nurshahira
title	Occurrence of Chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths
title_short	Occurrence of Chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths
title_full	Occurrence of Chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths
title_fullStr	Occurrence of Chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths
title_full_unstemmed	Occurrence of Chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths
title_sort	occurrence of chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths
publishDate	2012
url	http://psasir.upm.edu.my/id/eprint/71500/1/FPSK%28M%29%202012%2044%20IR.pdf http://psasir.upm.edu.my/id/eprint/71500/
_version_	1651869162114383872
score	13.211869

Occurrence of Chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths

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