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Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves

This report describes the effect of vaccination with attenuated P. multocida B:2 on wild-type P. multocida B:2 infection in calves. Calves were given 5 ml intranasal 107 CFU/mL live attenuated gdhA derivative of P. multocida B:2. Untreated calves were then mingled with the vaccinated Group. Control...

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Main Authors: Khin, Myat Nwe, Saad, Mohd Zamri, Mohamed Mustapha, Noordin, Abd Wahid, Mohd Effendy
Format: Article
Language:English
Published: Online Journal of Veterinary Research 2009
Online Access:http://psasir.upm.edu.my/id/eprint/7064/1/Effect%20of%20intranasal%20attenuated%20Pasteurella%20multocida%20B.pdf
http://psasir.upm.edu.my/id/eprint/7064/
http://onljvetres.com/pasteurellaabs2009.htm
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spelling my.upm.eprints.70642016-11-22T01:09:45Z http://psasir.upm.edu.my/id/eprint/7064/ Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves Khin, Myat Nwe Saad, Mohd Zamri Mohamed Mustapha, Noordin Abd Wahid, Mohd Effendy This report describes the effect of vaccination with attenuated P. multocida B:2 on wild-type P. multocida B:2 infection in calves. Calves were given 5 ml intranasal 107 CFU/mL live attenuated gdhA derivative of P. multocida B:2. Untreated calves were then mingled with the vaccinated Group. Control untreated calves were kept separate. After 6 weeks, all calves were challenged intra-tracheally with 107 CFU/mL of live wild-type P. multocida B:2. At Post-Mortem none of the vaccinated or mingled calves had lesions whereas controls revealed pulmonary petechial haemorrhages with acute pneumonia patches with neutrophils. Both exposed and commingled calves showed significantly (p<0.05) higher levels of serum IgG. P. multocida B:2 were successfully isolated only from the control calves of Group 3. These findings suggest that intranasal exposures to live attenuated P. multocida B:2 prevented infection by wild-type P. multocida B:2 and may have protected susceptible calves. Online Journal of Veterinary Research 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/7064/1/Effect%20of%20intranasal%20attenuated%20Pasteurella%20multocida%20B.pdf Khin, Myat Nwe and Saad, Mohd Zamri and Mohamed Mustapha, Noordin and Abd Wahid, Mohd Effendy (2009) Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves. Online Journal of Veterinary Research, 13 (2). pp. 65-72. ISSN 1328-925X http://onljvetres.com/pasteurellaabs2009.htm
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description This report describes the effect of vaccination with attenuated P. multocida B:2 on wild-type P. multocida B:2 infection in calves. Calves were given 5 ml intranasal 107 CFU/mL live attenuated gdhA derivative of P. multocida B:2. Untreated calves were then mingled with the vaccinated Group. Control untreated calves were kept separate. After 6 weeks, all calves were challenged intra-tracheally with 107 CFU/mL of live wild-type P. multocida B:2. At Post-Mortem none of the vaccinated or mingled calves had lesions whereas controls revealed pulmonary petechial haemorrhages with acute pneumonia patches with neutrophils. Both exposed and commingled calves showed significantly (p<0.05) higher levels of serum IgG. P. multocida B:2 were successfully isolated only from the control calves of Group 3. These findings suggest that intranasal exposures to live attenuated P. multocida B:2 prevented infection by wild-type P. multocida B:2 and may have protected susceptible calves.
format Article
author Khin, Myat Nwe
Saad, Mohd Zamri
Mohamed Mustapha, Noordin
Abd Wahid, Mohd Effendy
spellingShingle Khin, Myat Nwe
Saad, Mohd Zamri
Mohamed Mustapha, Noordin
Abd Wahid, Mohd Effendy
Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves
author_facet Khin, Myat Nwe
Saad, Mohd Zamri
Mohamed Mustapha, Noordin
Abd Wahid, Mohd Effendy
author_sort Khin, Myat Nwe
title Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves
title_short Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves
title_full Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves
title_fullStr Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves
title_full_unstemmed Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves
title_sort effect of intranasal attenuated pasteurella multocida b:2 on haemorrhagic septicaemia in calves
publisher Online Journal of Veterinary Research
publishDate 2009
url http://psasir.upm.edu.my/id/eprint/7064/1/Effect%20of%20intranasal%20attenuated%20Pasteurella%20multocida%20B.pdf
http://psasir.upm.edu.my/id/eprint/7064/
http://onljvetres.com/pasteurellaabs2009.htm
_version_ 1643823612399976448
score 13.211869

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