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Chemical constituents and biological activities of South East Asia marine sponges: a review

The ocean has an exceptional resource with various groups of natural products that are potentially useful for biomedical and other applications. Marine sponges have prominent characteristic natural products with high diversity. They produce many vital therapeutic metabolites with prominent biologica...

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Main Authors: Lee, Kah Nyan, Abas, Faridah, Maulidiani, Ahmed, Mediani, Leong, Sze Wei, Ismail, Intan Safinar, Shaari, Khozirah
Format: Article
Language:English
Published: Universiti Putra Malaysia Press 2019
Online Access:http://psasir.upm.edu.my/id/eprint/68705/1/27.%20JST%201171-2018.pdf
http://psasir.upm.edu.my/id/eprint/68705/
http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JST%20Vol.%2027%20(2)%20Apr.%202019/27.%20JST%201171-2018.pdf
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spelling my.upm.eprints.687052019-06-10T03:00:37Z http://psasir.upm.edu.my/id/eprint/68705/ Chemical constituents and biological activities of South East Asia marine sponges: a review Lee, Kah Nyan Abas, Faridah Maulidiani Ahmed, Mediani Leong, Sze Wei Ismail, Intan Safinar Shaari, Khozirah The ocean has an exceptional resource with various groups of natural products that are potentially useful for biomedical and other applications. Marine sponges have prominent characteristic natural products with high diversity. They produce many vital therapeutic metabolites with prominent biological activities. Marine invertebrates and microbial communities are the primary producers of such metabolites. Among the richest sources of these metabolites, class Demospongiae and the order Haplosclerida and genus Xestopongiae from family Petrosiidae are of interest. This review summarizes the research that has been conducted on two classes, eight orders, twelve families and fourteen genera of marine sponges available in the South East Asia region, covering the literature of the last 20 years. Ninety-five metabolites including alkaloids, sterols, terpenoids, quinones isolated from marine sponges collected in South East Asia along with their bioactivities especially cytotoxicity and antibacterial activities were reported in this review. Chemistry and biology are highly involved in studying marine sponges. Thus, tight collaboration is needed for understanding their taxonomy aspects. This review will outline chemistry and biological aspects, challenge, limitation, new idea and a clear future perspective on the discovery of new drugs from South East Asia's marine sponges. Universiti Putra Malaysia Press 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/68705/1/27.%20JST%201171-2018.pdf Lee, Kah Nyan and Abas, Faridah and Maulidiani and Ahmed, Mediani and Leong, Sze Wei and Ismail, Intan Safinar and Shaari, Khozirah (2019) Chemical constituents and biological activities of South East Asia marine sponges: a review. Pertanika Journal of Science & Technology, 27 (2). pp. 953-983. ISSN 0128-7680; ESSN: 2231-8526 http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JST%20Vol.%2027%20(2)%20Apr.%202019/27.%20JST%201171-2018.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The ocean has an exceptional resource with various groups of natural products that are potentially useful for biomedical and other applications. Marine sponges have prominent characteristic natural products with high diversity. They produce many vital therapeutic metabolites with prominent biological activities. Marine invertebrates and microbial communities are the primary producers of such metabolites. Among the richest sources of these metabolites, class Demospongiae and the order Haplosclerida and genus Xestopongiae from family Petrosiidae are of interest. This review summarizes the research that has been conducted on two classes, eight orders, twelve families and fourteen genera of marine sponges available in the South East Asia region, covering the literature of the last 20 years. Ninety-five metabolites including alkaloids, sterols, terpenoids, quinones isolated from marine sponges collected in South East Asia along with their bioactivities especially cytotoxicity and antibacterial activities were reported in this review. Chemistry and biology are highly involved in studying marine sponges. Thus, tight collaboration is needed for understanding their taxonomy aspects. This review will outline chemistry and biological aspects, challenge, limitation, new idea and a clear future perspective on the discovery of new drugs from South East Asia's marine sponges.
format Article
author Lee, Kah Nyan
Abas, Faridah
Maulidiani
Ahmed, Mediani
Leong, Sze Wei
Ismail, Intan Safinar
Shaari, Khozirah
spellingShingle Lee, Kah Nyan
Abas, Faridah
Maulidiani
Ahmed, Mediani
Leong, Sze Wei
Ismail, Intan Safinar
Shaari, Khozirah
Chemical constituents and biological activities of South East Asia marine sponges: a review
author_facet Lee, Kah Nyan
Abas, Faridah
Maulidiani
Ahmed, Mediani
Leong, Sze Wei
Ismail, Intan Safinar
Shaari, Khozirah
author_sort Lee, Kah Nyan
title Chemical constituents and biological activities of South East Asia marine sponges: a review
title_short Chemical constituents and biological activities of South East Asia marine sponges: a review
title_full Chemical constituents and biological activities of South East Asia marine sponges: a review
title_fullStr Chemical constituents and biological activities of South East Asia marine sponges: a review
title_full_unstemmed Chemical constituents and biological activities of South East Asia marine sponges: a review
title_sort chemical constituents and biological activities of south east asia marine sponges: a review
publisher Universiti Putra Malaysia Press
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/68705/1/27.%20JST%201171-2018.pdf
http://psasir.upm.edu.my/id/eprint/68705/
http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JST%20Vol.%2027%20(2)%20Apr.%202019/27.%20JST%201171-2018.pdf
_version_ 1643839281709449216
score 13.211869

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