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Regulation of bursa immune response by velogenic NDV

Newcastle disease virus (NDV) has been well characterised and classified. We have reported the differential regulation of cytokines/chemokines expression in spleen post-infected with genotype VII and VIII NDV. To further understand the regulation of adaptive immunity by these strains of NDV, we comp...

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Main Authors: Teo, Kristeen Ye Wen, Yeap, Swee Keong, Tan, Sheau Wei, Omar, Abdul Rahman, Ideris, Aini, Tan, Soon Guan, Mohammed Alitheen, Noorjahan Banu
Format: Conference or Workshop Item
Language:English
Published: Faculty of Veterinary Medicine, Universiti Putra Malaysia 2015
Online Access:http://psasir.upm.edu.my/id/eprint/65047/1/PA-46.pdf
http://psasir.upm.edu.my/id/eprint/65047/
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spelling my.upm.eprints.650472018-09-03T04:49:26Z http://psasir.upm.edu.my/id/eprint/65047/ Regulation of bursa immune response by velogenic NDV Teo, Kristeen Ye Wen Yeap, Swee Keong Tan, Sheau Wei Omar, Abdul Rahman Ideris, Aini Tan, Soon Guan Mohammed Alitheen, Noorjahan Banu Newcastle disease virus (NDV) has been well characterised and classified. We have reported the differential regulation of cytokines/chemokines expression in spleen post-infected with genotype VII and VIII NDV. To further understand the regulation of adaptive immunity by these strains of NDV, we compared the viral load, cytokines expression and oxidative stress in bursa of infected chicken. Genotype VII IBS002 was recorded with higher viral load in bursa of infected chicken comparing to genotype VIII AF2240. Although both strains of NDV upregulated proinflammatory cytokines (IFN-ɣ, CXCLi2 and IL-18) expression and nitric oxide in bursa of infected chicken, level of upregulation was greater in the bursa of AF2240 infected chicken. These findings supporting the idea of acute infection by AF2240, which resulted to earlier mortality than chicken infected with IBS002. Faculty of Veterinary Medicine, Universiti Putra Malaysia 2015 Conference or Workshop Item PeerReviewed text en http://psasir.upm.edu.my/id/eprint/65047/1/PA-46.pdf Teo, Kristeen Ye Wen and Yeap, Swee Keong and Tan, Sheau Wei and Omar, Abdul Rahman and Ideris, Aini and Tan, Soon Guan and Mohammed Alitheen, Noorjahan Banu (2015) Regulation of bursa immune response by velogenic NDV. In: World Veterinary Poultry Association (Malaysia Branch) and World's Poultry Science Association (Malaysia Branch) Scientific Conference 2015, 21-22 Sept. 2015, Kuala Lumpur Convention Centre, Kuala Lumpur, Malaysia. (pp. 210-211).
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Newcastle disease virus (NDV) has been well characterised and classified. We have reported the differential regulation of cytokines/chemokines expression in spleen post-infected with genotype VII and VIII NDV. To further understand the regulation of adaptive immunity by these strains of NDV, we compared the viral load, cytokines expression and oxidative stress in bursa of infected chicken. Genotype VII IBS002 was recorded with higher viral load in bursa of infected chicken comparing to genotype VIII AF2240. Although both strains of NDV upregulated proinflammatory cytokines (IFN-ɣ, CXCLi2 and IL-18) expression and nitric oxide in bursa of infected chicken, level of upregulation was greater in the bursa of AF2240 infected chicken. These findings supporting the idea of acute infection by AF2240, which resulted to earlier mortality than chicken infected with IBS002.
format Conference or Workshop Item
author Teo, Kristeen Ye Wen
Yeap, Swee Keong
Tan, Sheau Wei
Omar, Abdul Rahman
Ideris, Aini
Tan, Soon Guan
Mohammed Alitheen, Noorjahan Banu
spellingShingle Teo, Kristeen Ye Wen
Yeap, Swee Keong
Tan, Sheau Wei
Omar, Abdul Rahman
Ideris, Aini
Tan, Soon Guan
Mohammed Alitheen, Noorjahan Banu
Regulation of bursa immune response by velogenic NDV
author_facet Teo, Kristeen Ye Wen
Yeap, Swee Keong
Tan, Sheau Wei
Omar, Abdul Rahman
Ideris, Aini
Tan, Soon Guan
Mohammed Alitheen, Noorjahan Banu
author_sort Teo, Kristeen Ye Wen
title Regulation of bursa immune response by velogenic NDV
title_short Regulation of bursa immune response by velogenic NDV
title_full Regulation of bursa immune response by velogenic NDV
title_fullStr Regulation of bursa immune response by velogenic NDV
title_full_unstemmed Regulation of bursa immune response by velogenic NDV
title_sort regulation of bursa immune response by velogenic ndv
publisher Faculty of Veterinary Medicine, Universiti Putra Malaysia
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/65047/1/PA-46.pdf
http://psasir.upm.edu.my/id/eprint/65047/
_version_ 1643838203684192256
score 13.211869

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