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Mammary gland tumours in the dog, a spontaneous tumour model of comparative value to human breast cancer

Mammary gland tumours are the most common neoplasia diagnosed in the female dog. These tumours occur spontaneously or naturally as in humans, 50% of which are commonly diagnosed as malignant. Metastasis to other tissues especially the lung is a common cause of death in these dogs. Treatment of canin...

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Main Authors: Sahabi, Kabiru, Rajendren, Sujey Kumar, Foong, Jia Ning, Selvarajah, Gayathri Thevi
Format: Article
Language:English
Published: Universiti Putra Malaysia Press 2018
Online Access:http://psasir.upm.edu.my/id/eprint/64490/1/03%20JTAS%20Vol%2041%20%282%29%20May%202018_JTAS-1197-2017_pg541-574.pdf
http://psasir.upm.edu.my/id/eprint/64490/
http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2041%20(2)%20May.%202018/03%20JTAS%20Vol%2041%20(2)%20May%202018_JTAS-1197-2017_pg541-574.pdf
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spelling my.upm.eprints.644902018-07-06T09:17:33Z http://psasir.upm.edu.my/id/eprint/64490/ Mammary gland tumours in the dog, a spontaneous tumour model of comparative value to human breast cancer Sahabi, Kabiru Rajendren, Sujey Kumar Foong, Jia Ning Selvarajah, Gayathri Thevi Mammary gland tumours are the most common neoplasia diagnosed in the female dog. These tumours occur spontaneously or naturally as in humans, 50% of which are commonly diagnosed as malignant. Metastasis to other tissues especially the lung is a common cause of death in these dogs. Treatment of canine mammary gland tumours (CMT) involves mainly surgical resection with wide margin followed by chemotherapy with cytotoxic drugs for those with lymph node and distant metastasis. With the dog continuously described as a very suitable and valuable large animal model of human breast cancer, it becomes very obvious that CMT can be a model to further understand the biology of cancer as well as screening for new therapeutic agents that could be used to treat human breast cancer and CMT more effectively. This review focuses on research work that has been done on CMT over the past years, describing the epidemiology, diagnostics and recent advances in therapy for CMT as well as discussing the significance of the dog CMT as spontaneous animal model for human breast cancer. Universiti Putra Malaysia Press 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/64490/1/03%20JTAS%20Vol%2041%20%282%29%20May%202018_JTAS-1197-2017_pg541-574.pdf Sahabi, Kabiru and Rajendren, Sujey Kumar and Foong, Jia Ning and Selvarajah, Gayathri Thevi (2018) Mammary gland tumours in the dog, a spontaneous tumour model of comparative value to human breast cancer. Pertanika Journal of Tropical Agricultural Science, 41 (2). pp. 541-574. ISSN 1511-3701; ESSN: 2231-8542 http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2041%20(2)%20May.%202018/03%20JTAS%20Vol%2041%20(2)%20May%202018_JTAS-1197-2017_pg541-574.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Mammary gland tumours are the most common neoplasia diagnosed in the female dog. These tumours occur spontaneously or naturally as in humans, 50% of which are commonly diagnosed as malignant. Metastasis to other tissues especially the lung is a common cause of death in these dogs. Treatment of canine mammary gland tumours (CMT) involves mainly surgical resection with wide margin followed by chemotherapy with cytotoxic drugs for those with lymph node and distant metastasis. With the dog continuously described as a very suitable and valuable large animal model of human breast cancer, it becomes very obvious that CMT can be a model to further understand the biology of cancer as well as screening for new therapeutic agents that could be used to treat human breast cancer and CMT more effectively. This review focuses on research work that has been done on CMT over the past years, describing the epidemiology, diagnostics and recent advances in therapy for CMT as well as discussing the significance of the dog CMT as spontaneous animal model for human breast cancer.
format Article
author Sahabi, Kabiru
Rajendren, Sujey Kumar
Foong, Jia Ning
Selvarajah, Gayathri Thevi
spellingShingle Sahabi, Kabiru
Rajendren, Sujey Kumar
Foong, Jia Ning
Selvarajah, Gayathri Thevi
Mammary gland tumours in the dog, a spontaneous tumour model of comparative value to human breast cancer
author_facet Sahabi, Kabiru
Rajendren, Sujey Kumar
Foong, Jia Ning
Selvarajah, Gayathri Thevi
author_sort Sahabi, Kabiru
title Mammary gland tumours in the dog, a spontaneous tumour model of comparative value to human breast cancer
title_short Mammary gland tumours in the dog, a spontaneous tumour model of comparative value to human breast cancer
title_full Mammary gland tumours in the dog, a spontaneous tumour model of comparative value to human breast cancer
title_fullStr Mammary gland tumours in the dog, a spontaneous tumour model of comparative value to human breast cancer
title_full_unstemmed Mammary gland tumours in the dog, a spontaneous tumour model of comparative value to human breast cancer
title_sort mammary gland tumours in the dog, a spontaneous tumour model of comparative value to human breast cancer
publisher Universiti Putra Malaysia Press
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/64490/1/03%20JTAS%20Vol%2041%20%282%29%20May%202018_JTAS-1197-2017_pg541-574.pdf
http://psasir.upm.edu.my/id/eprint/64490/
http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2041%20(2)%20May.%202018/03%20JTAS%20Vol%2041%20(2)%20May%202018_JTAS-1197-2017_pg541-574.pdf
_version_ 1643838038738993152
score 13.222552

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