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Development of bio-health products from rice bran ferulates

Rice bran, the major byproduct of the rice milling industry is also the source of high quality vegetable oil viz. rice bran oil (RBO). Rice bran oil has attracted much medical attention due to its strong hypocholesterolemic properties primarily attributable to its balanced fatty acid composition and...

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Main Authors: Bagalkotkar, Gururaj, Ismail, Maznah, Ho, K. L., R., Nur Hazwani
Format: Conference or Workshop Item
Language:English
Published: Sarawak Biodiversity Centre 2008
Online Access:http://psasir.upm.edu.my/id/eprint/64275/1/PROCEEDING_100719-12.pdf
http://psasir.upm.edu.my/id/eprint/64275/
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spelling my.upm.eprints.642752018-07-04T02:31:41Z http://psasir.upm.edu.my/id/eprint/64275/ Development of bio-health products from rice bran ferulates Bagalkotkar, Gururaj Ismail, Maznah Ho, K. L. R., Nur Hazwani Rice bran, the major byproduct of the rice milling industry is also the source of high quality vegetable oil viz. rice bran oil (RBO). Rice bran oil has attracted much medical attention due to its strong hypocholesterolemic properties primarily attributable to its balanced fatty acid composition and high levels of antioxidant phytochemicals such as oryzanols, tocopherols and tocotrienols. Rice bran and rice bran oil have particularly been under investigation recently because of their potential benefits. Rice bran oil is also rich source of phytochemicals with nutraceutical and antioxidant properties and product development could certainly add value to these bio-resources that are available in abundance. Nevertheless, there is yet a study on the biological properties and identification of stabilized rice bran phytochemical rich fractions and biotransformation products from rice bran oil. The phytochemical rich fractions from RBO were successfully extracted using SFE and sequential extraction methods. Ferulate esters were isolated and purified using R-HPLC and Prep-HPLC and analyzed using LC-MS (Q-TOF). Antioxidant activity of ferulate rich fractions from RBO has been determined using DPPH method and anticancer activity of ferulate derivatives from RBO has been determined using MTS assay against HT-29 cancer cell lines. The extracted ferulic acid and its derivatives (campesteryl ferulate (1) and sitosterol ferulate (2)) were tested against human colon cancer (HT-29) cell line using MTS cytotoxic assay. Ferulic acid derivatives (campesteryl ferulate (1) and sitosterol ferulate (2)) exhibited significant cytotoxic activity against the tested cancer cell line with the IC50 values of 420 and 465 μg/ml, respectively. These enriched fractions and phtytochemicals from rice bran could find application as antitumour agents and natural antioxidants for processed foods or as dietary supplements. Sarawak Biodiversity Centre 2008 Conference or Workshop Item PeerReviewed text en http://psasir.upm.edu.my/id/eprint/64275/1/PROCEEDING_100719-12.pdf Bagalkotkar, Gururaj and Ismail, Maznah and Ho, K. L. and R., Nur Hazwani (2008) Development of bio-health products from rice bran ferulates. In: Biodiversity and Biotechnology Symposium 2008, 19-21 Nov. 2008, Kuching, Sarawak, Malaysia. (pp. 361-363).
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Rice bran, the major byproduct of the rice milling industry is also the source of high quality vegetable oil viz. rice bran oil (RBO). Rice bran oil has attracted much medical attention due to its strong hypocholesterolemic properties primarily attributable to its balanced fatty acid composition and high levels of antioxidant phytochemicals such as oryzanols, tocopherols and tocotrienols. Rice bran and rice bran oil have particularly been under investigation recently because of their potential benefits. Rice bran oil is also rich source of phytochemicals with nutraceutical and antioxidant properties and product development could certainly add value to these bio-resources that are available in abundance. Nevertheless, there is yet a study on the biological properties and identification of stabilized rice bran phytochemical rich fractions and biotransformation products from rice bran oil. The phytochemical rich fractions from RBO were successfully extracted using SFE and sequential extraction methods. Ferulate esters were isolated and purified using R-HPLC and Prep-HPLC and analyzed using LC-MS (Q-TOF). Antioxidant activity of ferulate rich fractions from RBO has been determined using DPPH method and anticancer activity of ferulate derivatives from RBO has been determined using MTS assay against HT-29 cancer cell lines. The extracted ferulic acid and its derivatives (campesteryl ferulate (1) and sitosterol ferulate (2)) were tested against human colon cancer (HT-29) cell line using MTS cytotoxic assay. Ferulic acid derivatives (campesteryl ferulate (1) and sitosterol ferulate (2)) exhibited significant cytotoxic activity against the tested cancer cell line with the IC50 values of 420 and 465 μg/ml, respectively. These enriched fractions and phtytochemicals from rice bran could find application as antitumour agents and natural antioxidants for processed foods or as dietary supplements.
format Conference or Workshop Item
author Bagalkotkar, Gururaj
Ismail, Maznah
Ho, K. L.
R., Nur Hazwani
spellingShingle Bagalkotkar, Gururaj
Ismail, Maznah
Ho, K. L.
R., Nur Hazwani
Development of bio-health products from rice bran ferulates
author_facet Bagalkotkar, Gururaj
Ismail, Maznah
Ho, K. L.
R., Nur Hazwani
author_sort Bagalkotkar, Gururaj
title Development of bio-health products from rice bran ferulates
title_short Development of bio-health products from rice bran ferulates
title_full Development of bio-health products from rice bran ferulates
title_fullStr Development of bio-health products from rice bran ferulates
title_full_unstemmed Development of bio-health products from rice bran ferulates
title_sort development of bio-health products from rice bran ferulates
publisher Sarawak Biodiversity Centre
publishDate 2008
url http://psasir.upm.edu.my/id/eprint/64275/1/PROCEEDING_100719-12.pdf
http://psasir.upm.edu.my/id/eprint/64275/
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score 13.211869

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