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Phytochemicals and cytotoxic studies of Zingiber cassumunar Roxb.

Zingiber cassumunar belongs to the family Zingiberaceae and is locally known as ‘bonglai’ in Malay and ‘plai’ among Thais. It has been traditionally used as treatment for women after giving birth or during confinement. Extraction and isolation of phytochemical compounds from the rhizome of Zingiber...

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Main Authors: Azid, Mohd Zulkhairi, Sukari, Mohd Aspollah, Ee, Gwendoline Cheng Lian, Abdul, Ahmad Bustamam
Format: Article
Language:English
Published: Malaysian Agricultural Research and Development Institute (MARDI) 2017
Online Access:http://psasir.upm.edu.my/id/eprint/64083/1/Phytochemicals%20and%20cytotoxic%20studies%20of%20Zingiber%20cassumunar%20Roxb..pdf
http://psasir.upm.edu.my/id/eprint/64083/
http://ejtafs.mardi.gov.my/index.php/publication/issues/current/194-2017/volume-45-no-2/1392-450208
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spelling my.upm.eprints.640832018-06-11T08:17:47Z http://psasir.upm.edu.my/id/eprint/64083/ Phytochemicals and cytotoxic studies of Zingiber cassumunar Roxb. Azid, Mohd Zulkhairi Sukari, Mohd Aspollah Ee, Gwendoline Cheng Lian Abdul, Ahmad Bustamam Zingiber cassumunar belongs to the family Zingiberaceae and is locally known as ‘bonglai’ in Malay and ‘plai’ among Thais. It has been traditionally used as treatment for women after giving birth or during confinement. Extraction and isolation of phytochemical compounds from the rhizome of Zingiber cassumunar Roxb. using various chromatographic techniques identified five compounds, namely, cis-3-(3’,4’-dimethoxyphenyl)-4-[(E)-3’’’,4’’’-dimethoxystyryl]cyclo-hex- 1-ene (1), (E)-4-(3’,4’-dimethoxyphenyl) but-3-en-1-ol (2), 3,4-dimethoxybenzoic acid (3), 8-(13,14-dimethoxyphenyl)-2-methoxynaphto-1,4-quinone (4) and β-sitosterol (5). Structure elucidation of these compounds was carried out by various spectroscopic means. The cytotoxic activity of isolated compounds against human T-acute lymphoblastic leukemia cancer cells (CEMss) and human cervical cancer cells (HeLa) were carried out using MTT assay. Only the chloroform extract showed strong activity against CEMss cancer cells with IC50 values of 9.20 ± 0.02 μg/ml. Compounds (1), (2) and (4) showed strong cytotoxicity activity against HeLa cancer cells with IC50 values <15 μg/ml whilst compounds (1) and (4) demonstrated moderate cytotoxicity activity against CEMss cells with 1C50 values of 28.34 ± 0.39 μg/ml and 25.96 ± 0.94 μg/ml respectively. Therefore, Zingiber cassumunar has high potential to be commercially domesticated based on the anti-cancer properties of its compounds. Malaysian Agricultural Research and Development Institute (MARDI) 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/64083/1/Phytochemicals%20and%20cytotoxic%20studies%20of%20Zingiber%20cassumunar%20Roxb..pdf Azid, Mohd Zulkhairi and Sukari, Mohd Aspollah and Ee, Gwendoline Cheng Lian and Abdul, Ahmad Bustamam (2017) Phytochemicals and cytotoxic studies of Zingiber cassumunar Roxb. Journal of Tropical Agriculture and Food Science, 45 (2). pp. 187-197. ISSN 1394-9829; ESSN: 2289-9650 http://ejtafs.mardi.gov.my/index.php/publication/issues/current/194-2017/volume-45-no-2/1392-450208
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Zingiber cassumunar belongs to the family Zingiberaceae and is locally known as ‘bonglai’ in Malay and ‘plai’ among Thais. It has been traditionally used as treatment for women after giving birth or during confinement. Extraction and isolation of phytochemical compounds from the rhizome of Zingiber cassumunar Roxb. using various chromatographic techniques identified five compounds, namely, cis-3-(3’,4’-dimethoxyphenyl)-4-[(E)-3’’’,4’’’-dimethoxystyryl]cyclo-hex- 1-ene (1), (E)-4-(3’,4’-dimethoxyphenyl) but-3-en-1-ol (2), 3,4-dimethoxybenzoic acid (3), 8-(13,14-dimethoxyphenyl)-2-methoxynaphto-1,4-quinone (4) and β-sitosterol (5). Structure elucidation of these compounds was carried out by various spectroscopic means. The cytotoxic activity of isolated compounds against human T-acute lymphoblastic leukemia cancer cells (CEMss) and human cervical cancer cells (HeLa) were carried out using MTT assay. Only the chloroform extract showed strong activity against CEMss cancer cells with IC50 values of 9.20 ± 0.02 μg/ml. Compounds (1), (2) and (4) showed strong cytotoxicity activity against HeLa cancer cells with IC50 values <15 μg/ml whilst compounds (1) and (4) demonstrated moderate cytotoxicity activity against CEMss cells with 1C50 values of 28.34 ± 0.39 μg/ml and 25.96 ± 0.94 μg/ml respectively. Therefore, Zingiber cassumunar has high potential to be commercially domesticated based on the anti-cancer properties of its compounds.
format Article
author Azid, Mohd Zulkhairi
Sukari, Mohd Aspollah
Ee, Gwendoline Cheng Lian
Abdul, Ahmad Bustamam
spellingShingle Azid, Mohd Zulkhairi
Sukari, Mohd Aspollah
Ee, Gwendoline Cheng Lian
Abdul, Ahmad Bustamam
Phytochemicals and cytotoxic studies of Zingiber cassumunar Roxb.
author_facet Azid, Mohd Zulkhairi
Sukari, Mohd Aspollah
Ee, Gwendoline Cheng Lian
Abdul, Ahmad Bustamam
author_sort Azid, Mohd Zulkhairi
title Phytochemicals and cytotoxic studies of Zingiber cassumunar Roxb.
title_short Phytochemicals and cytotoxic studies of Zingiber cassumunar Roxb.
title_full Phytochemicals and cytotoxic studies of Zingiber cassumunar Roxb.
title_fullStr Phytochemicals and cytotoxic studies of Zingiber cassumunar Roxb.
title_full_unstemmed Phytochemicals and cytotoxic studies of Zingiber cassumunar Roxb.
title_sort phytochemicals and cytotoxic studies of zingiber cassumunar roxb.
publisher Malaysian Agricultural Research and Development Institute (MARDI)
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/64083/1/Phytochemicals%20and%20cytotoxic%20studies%20of%20Zingiber%20cassumunar%20Roxb..pdf
http://psasir.upm.edu.my/id/eprint/64083/
http://ejtafs.mardi.gov.my/index.php/publication/issues/current/194-2017/volume-45-no-2/1392-450208
_version_ 1643837922031435776
score 13.211869

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