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Haematological and histopathological evaluation of dried kacangma (Leonurus sibiricus) in New Zealand White rabbits

Kacangma (Leonurus sibiricus L.) is a popular traditional herb that has been consumed for decades by the people of Sarawak as herbal medicine and culinary ingredient. This study was conducted to evaluate the toxicity of kacangma herb on New Zealand White male and female rabbits through subchronic st...

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Main Authors: Chua, Hun Pin, Marimuthu, Murugaiyah, Abdullah, Aminah
Format: Article
Language:English
Published: Malaysian Agricultural Research and Development Institute (MARDI) 2016
Online Access:http://psasir.upm.edu.my/id/eprint/64081/1/Haematological%20and%20histopathological%20evaluation%20of%20dried%20kacangma%20%28Leonurus%20sibiricus%29%20in%20New%20Zealand%20White%20rabbits.pdf
http://psasir.upm.edu.my/id/eprint/64081/
http://ejtafs.mardi.gov.my/index.php/publication/issues/current/193-2017/volume-45-no-1/1375-450105
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spelling my.upm.eprints.640812018-06-11T08:17:43Z http://psasir.upm.edu.my/id/eprint/64081/ Haematological and histopathological evaluation of dried kacangma (Leonurus sibiricus) in New Zealand White rabbits Chua, Hun Pin Marimuthu, Murugaiyah Abdullah, Aminah Kacangma (Leonurus sibiricus L.) is a popular traditional herb that has been consumed for decades by the people of Sarawak as herbal medicine and culinary ingredient. This study was conducted to evaluate the toxicity of kacangma herb on New Zealand White male and female rabbits through subchronic studies. Effects of kacangma herb intake at the level of 0.5, 5.0 and 25.0 g/kg body weight was evaluated for 90 days with focus on hematological and histopathological studies. The haematological study revealed no significant changes in all parameters studied i.e. heamoglobin, red blood cell value, white blood cell value, packed cell volume, mean cell volume, mean cell haemoglobin and mean cell haemoglobin concentration. Vice versa, in the histophatological study, administration of dried kacangma herb at medium and high dose was found to cause adverse effects on histopathological structure in liver and kidney of both male and female rabbits. However, since low dose group showed no significant differences to the control group, therefore it is considered safe and less chance of developing toxicity if the herb is consumed at the low dose of 0.5 g/kg body weight as observed throughout the 90 days period of subchronic study. Malaysian Agricultural Research and Development Institute (MARDI) 2016 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/64081/1/Haematological%20and%20histopathological%20evaluation%20of%20dried%20kacangma%20%28Leonurus%20sibiricus%29%20in%20New%20Zealand%20White%20rabbits.pdf Chua, Hun Pin and Marimuthu, Murugaiyah and Abdullah, Aminah (2016) Haematological and histopathological evaluation of dried kacangma (Leonurus sibiricus) in New Zealand White rabbits. Journal of Tropical Agriculture and Food Science, 44 (2). pp. 51-59. ISSN 1394-9829; ESSN: 2289-9650 http://ejtafs.mardi.gov.my/index.php/publication/issues/current/193-2017/volume-45-no-1/1375-450105
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Kacangma (Leonurus sibiricus L.) is a popular traditional herb that has been consumed for decades by the people of Sarawak as herbal medicine and culinary ingredient. This study was conducted to evaluate the toxicity of kacangma herb on New Zealand White male and female rabbits through subchronic studies. Effects of kacangma herb intake at the level of 0.5, 5.0 and 25.0 g/kg body weight was evaluated for 90 days with focus on hematological and histopathological studies. The haematological study revealed no significant changes in all parameters studied i.e. heamoglobin, red blood cell value, white blood cell value, packed cell volume, mean cell volume, mean cell haemoglobin and mean cell haemoglobin concentration. Vice versa, in the histophatological study, administration of dried kacangma herb at medium and high dose was found to cause adverse effects on histopathological structure in liver and kidney of both male and female rabbits. However, since low dose group showed no significant differences to the control group, therefore it is considered safe and less chance of developing toxicity if the herb is consumed at the low dose of 0.5 g/kg body weight as observed throughout the 90 days period of subchronic study.
format Article
author Chua, Hun Pin
Marimuthu, Murugaiyah
Abdullah, Aminah
spellingShingle Chua, Hun Pin
Marimuthu, Murugaiyah
Abdullah, Aminah
Haematological and histopathological evaluation of dried kacangma (Leonurus sibiricus) in New Zealand White rabbits
author_facet Chua, Hun Pin
Marimuthu, Murugaiyah
Abdullah, Aminah
author_sort Chua, Hun Pin
title Haematological and histopathological evaluation of dried kacangma (Leonurus sibiricus) in New Zealand White rabbits
title_short Haematological and histopathological evaluation of dried kacangma (Leonurus sibiricus) in New Zealand White rabbits
title_full Haematological and histopathological evaluation of dried kacangma (Leonurus sibiricus) in New Zealand White rabbits
title_fullStr Haematological and histopathological evaluation of dried kacangma (Leonurus sibiricus) in New Zealand White rabbits
title_full_unstemmed Haematological and histopathological evaluation of dried kacangma (Leonurus sibiricus) in New Zealand White rabbits
title_sort haematological and histopathological evaluation of dried kacangma (leonurus sibiricus) in new zealand white rabbits
publisher Malaysian Agricultural Research and Development Institute (MARDI)
publishDate 2016
url http://psasir.upm.edu.my/id/eprint/64081/1/Haematological%20and%20histopathological%20evaluation%20of%20dried%20kacangma%20%28Leonurus%20sibiricus%29%20in%20New%20Zealand%20White%20rabbits.pdf
http://psasir.upm.edu.my/id/eprint/64081/
http://ejtafs.mardi.gov.my/index.php/publication/issues/current/193-2017/volume-45-no-1/1375-450105
_version_ 1643837921438990336
score 13.211869

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