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Three divergent subpopulations of the malaria parasite Plasmodium knowlesi

Multilocus microsatellite genotyping of Plasmodium knowlesi isolates previously indicated 2 divergent parasite subpopulations in humans on the island of Borneo, each associated with a different macaque reservoir host species. Geographic divergence was also apparent, and independent sequence data hav...

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Main Authors: Divis, Paul C. S., Lee, C. Lin, Rovie-Ryan, Jeffrine Japning, Kadir, Khamisah Abdul, Anderios, Fread, Hisam, Shamilah, Sharma, Reuben S. K., Singh, Balbir, Conway, David J.
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2017
Online Access:http://psasir.upm.edu.my/id/eprint/63570/1/Three%20divergent%20subpopulations%20of%20the%20malaria%20Parasite%20plasmodium%20knowlesi.pdf
http://psasir.upm.edu.my/id/eprint/63570/
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spelling my.upm.eprints.635702018-11-05T02:23:06Z http://psasir.upm.edu.my/id/eprint/63570/ Three divergent subpopulations of the malaria parasite Plasmodium knowlesi Divis, Paul C. S. Lee, C. Lin Rovie-Ryan, Jeffrine Japning Kadir, Khamisah Abdul Anderios, Fread Hisam, Shamilah Sharma, Reuben S. K. Singh, Balbir Conway, David J. Multilocus microsatellite genotyping of Plasmodium knowlesi isolates previously indicated 2 divergent parasite subpopulations in humans on the island of Borneo, each associated with a different macaque reservoir host species. Geographic divergence was also apparent, and independent sequence data have indicated particularly deep divergence between parasites from mainland Southeast Asia and Borneo. To resolve the overall population structure, multilocus microsatellite genotyping was conducted on a new sample of 182 P. knowlesi infections (obtained from 134 humans and 48 wild macaques) from diverse areas of Malaysia, first analyzed separately and then in combination with previous data. All analyses confirmed 2 divergent clusters of human cases in Malaysian Borneo, associated with long-tailed macaques and pig-tailed macaques, and a third cluster in humans and most macaques in peninsular Malaysia. High levels of pairwise divergence between each of these sympatric and allopatric subpopulations have implications for the epidemiology and control of this zoonotic species. Centers for Disease Control and Prevention 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/63570/1/Three%20divergent%20subpopulations%20of%20the%20malaria%20Parasite%20plasmodium%20knowlesi.pdf Divis, Paul C. S. and Lee, C. Lin and Rovie-Ryan, Jeffrine Japning and Kadir, Khamisah Abdul and Anderios, Fread and Hisam, Shamilah and Sharma, Reuben S. K. and Singh, Balbir and Conway, David J. (2017) Three divergent subpopulations of the malaria parasite Plasmodium knowlesi. Emerging Infectious Diseases, 23 (4). 616 - 624. ISSN 1080-6040; ESSN: 1080-6059 10.3201/eid2304.161738
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Multilocus microsatellite genotyping of Plasmodium knowlesi isolates previously indicated 2 divergent parasite subpopulations in humans on the island of Borneo, each associated with a different macaque reservoir host species. Geographic divergence was also apparent, and independent sequence data have indicated particularly deep divergence between parasites from mainland Southeast Asia and Borneo. To resolve the overall population structure, multilocus microsatellite genotyping was conducted on a new sample of 182 P. knowlesi infections (obtained from 134 humans and 48 wild macaques) from diverse areas of Malaysia, first analyzed separately and then in combination with previous data. All analyses confirmed 2 divergent clusters of human cases in Malaysian Borneo, associated with long-tailed macaques and pig-tailed macaques, and a third cluster in humans and most macaques in peninsular Malaysia. High levels of pairwise divergence between each of these sympatric and allopatric subpopulations have implications for the epidemiology and control of this zoonotic species.
format Article
author Divis, Paul C. S.
Lee, C. Lin
Rovie-Ryan, Jeffrine Japning
Kadir, Khamisah Abdul
Anderios, Fread
Hisam, Shamilah
Sharma, Reuben S. K.
Singh, Balbir
Conway, David J.
spellingShingle Divis, Paul C. S.
Lee, C. Lin
Rovie-Ryan, Jeffrine Japning
Kadir, Khamisah Abdul
Anderios, Fread
Hisam, Shamilah
Sharma, Reuben S. K.
Singh, Balbir
Conway, David J.
Three divergent subpopulations of the malaria parasite Plasmodium knowlesi
author_facet Divis, Paul C. S.
Lee, C. Lin
Rovie-Ryan, Jeffrine Japning
Kadir, Khamisah Abdul
Anderios, Fread
Hisam, Shamilah
Sharma, Reuben S. K.
Singh, Balbir
Conway, David J.
author_sort Divis, Paul C. S.
title Three divergent subpopulations of the malaria parasite Plasmodium knowlesi
title_short Three divergent subpopulations of the malaria parasite Plasmodium knowlesi
title_full Three divergent subpopulations of the malaria parasite Plasmodium knowlesi
title_fullStr Three divergent subpopulations of the malaria parasite Plasmodium knowlesi
title_full_unstemmed Three divergent subpopulations of the malaria parasite Plasmodium knowlesi
title_sort three divergent subpopulations of the malaria parasite plasmodium knowlesi
publisher Centers for Disease Control and Prevention
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/63570/1/Three%20divergent%20subpopulations%20of%20the%20malaria%20Parasite%20plasmodium%20knowlesi.pdf
http://psasir.upm.edu.my/id/eprint/63570/
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score 13.211869

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