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The synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications

Minerals substituted apatite (M-HA) nanoparticles were prepared by the precipitation of minerals and phosphate reactants in choline chloride-Thiourea (ChCl–TU) deep eutectic solvent (DESs) as a facile and green way approach. After preparation of nanoparticles (F-M-HA (F = Fresh solvent)), the DESs w...

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Main Authors: Govindaraj, Dharman, Rajan, Mariappan, Munusamy, Murugan A., Alarfaj, Abdullah A., Sadasivuni, Kishor Kumar, Kumar, S. Suresh
Format: Article
Language:English
Published: Elsevier 2017
Online Access:http://psasir.upm.edu.my/id/eprint/63534/1/The%20synthesis%2C%20characterization%20and%20in%20vivo%20study%20of%20mineral%20substituted%20hydroxyapatite%20for%20prospective%20bone%20tissue%20rejuvenation%20applications.pdf
http://psasir.upm.edu.my/id/eprint/63534/
https://www.sciencedirect.com/science/article/pii/S1549963417301478?via%3Dihub
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spelling my.upm.eprints.635342018-11-05T00:00:57Z http://psasir.upm.edu.my/id/eprint/63534/ The synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications Govindaraj, Dharman Rajan, Mariappan Munusamy, Murugan A. Alarfaj, Abdullah A. Sadasivuni, Kishor Kumar Kumar, S. Suresh Minerals substituted apatite (M-HA) nanoparticles were prepared by the precipitation of minerals and phosphate reactants in choline chloride-Thiourea (ChCl–TU) deep eutectic solvent (DESs) as a facile and green way approach. After preparation of nanoparticles (F-M-HA (F = Fresh solvent)), the DESs was recovered productively and reprocess for the preparation of R-M-HA nanoparticles (R = Recycle solvent).The functional groups, phase, surface texture and the elemental composition of the M-HA nanoparticles were evaluated by advance characterization methods. The physicochemical results of the current work authoritative the successful uses of the novel (ChCl–TU) DESs as eco-friendly recuperate and give the medium for the preparation of M-HA nanoparticles. Moreover, the as-synthesized both M-HA nanoparticles exhibit excellent biocompatibility, consisting of cell co-cultivation and cell adhesion, in vivo according to surgical implantation of Wistar rats. Elsevier 2017-11 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/63534/1/The%20synthesis%2C%20characterization%20and%20in%20vivo%20study%20of%20mineral%20substituted%20hydroxyapatite%20for%20prospective%20bone%20tissue%20rejuvenation%20applications.pdf Govindaraj, Dharman and Rajan, Mariappan and Munusamy, Murugan A. and Alarfaj, Abdullah A. and Sadasivuni, Kishor Kumar and Kumar, S. Suresh (2017) The synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications. Nanomedicine: Nanotechnology Biology and Medicine, 13 (8). 2661 - 2669. ISSN 1549-9634 https://www.sciencedirect.com/science/article/pii/S1549963417301478?via%3Dihub 10.1016/j.nano.2017.07.017
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Minerals substituted apatite (M-HA) nanoparticles were prepared by the precipitation of minerals and phosphate reactants in choline chloride-Thiourea (ChCl–TU) deep eutectic solvent (DESs) as a facile and green way approach. After preparation of nanoparticles (F-M-HA (F = Fresh solvent)), the DESs was recovered productively and reprocess for the preparation of R-M-HA nanoparticles (R = Recycle solvent).The functional groups, phase, surface texture and the elemental composition of the M-HA nanoparticles were evaluated by advance characterization methods. The physicochemical results of the current work authoritative the successful uses of the novel (ChCl–TU) DESs as eco-friendly recuperate and give the medium for the preparation of M-HA nanoparticles. Moreover, the as-synthesized both M-HA nanoparticles exhibit excellent biocompatibility, consisting of cell co-cultivation and cell adhesion, in vivo according to surgical implantation of Wistar rats.
format Article
author Govindaraj, Dharman
Rajan, Mariappan
Munusamy, Murugan A.
Alarfaj, Abdullah A.
Sadasivuni, Kishor Kumar
Kumar, S. Suresh
spellingShingle Govindaraj, Dharman
Rajan, Mariappan
Munusamy, Murugan A.
Alarfaj, Abdullah A.
Sadasivuni, Kishor Kumar
Kumar, S. Suresh
The synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications
author_facet Govindaraj, Dharman
Rajan, Mariappan
Munusamy, Murugan A.
Alarfaj, Abdullah A.
Sadasivuni, Kishor Kumar
Kumar, S. Suresh
author_sort Govindaraj, Dharman
title The synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications
title_short The synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications
title_full The synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications
title_fullStr The synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications
title_full_unstemmed The synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications
title_sort synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications
publisher Elsevier
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/63534/1/The%20synthesis%2C%20characterization%20and%20in%20vivo%20study%20of%20mineral%20substituted%20hydroxyapatite%20for%20prospective%20bone%20tissue%20rejuvenation%20applications.pdf
http://psasir.upm.edu.my/id/eprint/63534/
https://www.sciencedirect.com/science/article/pii/S1549963417301478?via%3Dihub
_version_ 1643837824756088832
score 13.211869

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