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Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats

The predominant saturated fatty acids (SFA) in human diets are lauric acid (LA, C12:0), myristic acid (MA, C14:0), palmitic acid (PA, C16:0) and stearic acid (SA, C18:0). The aim of this study was to investigate whether diets containing individual SFA together with excess simple carbohydrates induce...

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Main Authors: Sekar, Sunderajhan, Shafie, Siti Raihanah, Prasadam, Indira, Crawford, Ross, Panchal, Sunil K., Brown, Lindsay, Xiao, Yin
Format: Article
Language:English
Published: Nature Publishing Group 2017
Online Access:http://psasir.upm.edu.my/id/eprint/63174/1/Saturated%20fatty%20acids%20induce%20development%20of%20both%20metabolic%20syndrome%20and%20osteoarthritis%20in%20rats.pdf
http://psasir.upm.edu.my/id/eprint/63174/
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spelling my.upm.eprints.631742018-08-20T01:19:01Z http://psasir.upm.edu.my/id/eprint/63174/ Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats Sekar, Sunderajhan Shafie, Siti Raihanah Prasadam, Indira Crawford, Ross Panchal, Sunil K. Brown, Lindsay Xiao, Yin The predominant saturated fatty acids (SFA) in human diets are lauric acid (LA, C12:0), myristic acid (MA, C14:0), palmitic acid (PA, C16:0) and stearic acid (SA, C18:0). The aim of this study was to investigate whether diets containing individual SFA together with excess simple carbohydrates induce osteoarthritis (OA)-like changes in knee joints and signs of metabolic syndrome in rats. Rats were given either a corn starch diet or a diet composed of simple carbohydrates together with 20% LA, MA, PA, SA or beef tallow for 16 weeks. Rats fed beef tallow, SA, MA or PA diets developed signs of metabolic syndrome, and also exhibited cartilage degradation and subchondral bone changes similar to OA. In contrast, replacement of beef tallow with LA decreased signs of metabolic syndrome together with decreased cartilage degradation. Furthermore, PA and SA but not LA increased release of matrix sulphated proteoglycans in cultures of bovine cartilage explants or human chondrocytes. In conclusion, we have shown that longer-chain dietary SFA in rats induce both metabolic syndrome and OA-like knee changes. Thus, diets containing SFA are strongly relevant to the development or prevention of both OA and metabolic syndrome. Nature Publishing Group 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/63174/1/Saturated%20fatty%20acids%20induce%20development%20of%20both%20metabolic%20syndrome%20and%20osteoarthritis%20in%20rats.pdf Sekar, Sunderajhan and Shafie, Siti Raihanah and Prasadam, Indira and Crawford, Ross and Panchal, Sunil K. and Brown, Lindsay and Xiao, Yin (2017) Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats. Scientific Reports, 7. art. no. 46457. pp. 1-11. ISSN 2045-2322 10.1038/srep46457
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The predominant saturated fatty acids (SFA) in human diets are lauric acid (LA, C12:0), myristic acid (MA, C14:0), palmitic acid (PA, C16:0) and stearic acid (SA, C18:0). The aim of this study was to investigate whether diets containing individual SFA together with excess simple carbohydrates induce osteoarthritis (OA)-like changes in knee joints and signs of metabolic syndrome in rats. Rats were given either a corn starch diet or a diet composed of simple carbohydrates together with 20% LA, MA, PA, SA or beef tallow for 16 weeks. Rats fed beef tallow, SA, MA or PA diets developed signs of metabolic syndrome, and also exhibited cartilage degradation and subchondral bone changes similar to OA. In contrast, replacement of beef tallow with LA decreased signs of metabolic syndrome together with decreased cartilage degradation. Furthermore, PA and SA but not LA increased release of matrix sulphated proteoglycans in cultures of bovine cartilage explants or human chondrocytes. In conclusion, we have shown that longer-chain dietary SFA in rats induce both metabolic syndrome and OA-like knee changes. Thus, diets containing SFA are strongly relevant to the development or prevention of both OA and metabolic syndrome.
format Article
author Sekar, Sunderajhan
Shafie, Siti Raihanah
Prasadam, Indira
Crawford, Ross
Panchal, Sunil K.
Brown, Lindsay
Xiao, Yin
spellingShingle Sekar, Sunderajhan
Shafie, Siti Raihanah
Prasadam, Indira
Crawford, Ross
Panchal, Sunil K.
Brown, Lindsay
Xiao, Yin
Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats
author_facet Sekar, Sunderajhan
Shafie, Siti Raihanah
Prasadam, Indira
Crawford, Ross
Panchal, Sunil K.
Brown, Lindsay
Xiao, Yin
author_sort Sekar, Sunderajhan
title Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats
title_short Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats
title_full Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats
title_fullStr Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats
title_full_unstemmed Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats
title_sort saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats
publisher Nature Publishing Group
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/63174/1/Saturated%20fatty%20acids%20induce%20development%20of%20both%20metabolic%20syndrome%20and%20osteoarthritis%20in%20rats.pdf
http://psasir.upm.edu.my/id/eprint/63174/
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score 13.211869

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