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Novel anti-tuberculosis nanodelivery formulation of ethambutol with graphene oxide

Tuberculosis (TB) is a bacterial disease responsible for millions of infections and preventable deaths each year. Its treatment is complicated by patients’ noncompliance due to dosing frequency, lengthy treatment, and adverse side effects associated with current chemotherapy. However, no modificatio...

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Main Authors: Bullo, Saifullah, Chrzastek, Alina, Maitra, Arundhati, Naeemullah, Bullo, Fakurazi, Sharida, Bhakta, Sanjib, Hussein, Mohd Zobir
Format: Article
Language:English
Published: Multidisciplinary Digital Publishing Institute 2017
Online Access:http://psasir.upm.edu.my/id/eprint/62548/1/TB.pdf
http://psasir.upm.edu.my/id/eprint/62548/
https://www.mdpi.com/1420-3049/22/10/1560
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spelling my.upm.eprints.625482021-04-29T02:16:01Z http://psasir.upm.edu.my/id/eprint/62548/ Novel anti-tuberculosis nanodelivery formulation of ethambutol with graphene oxide Bullo, Saifullah Chrzastek, Alina Maitra, Arundhati Naeemullah, Bullo Fakurazi, Sharida Bhakta, Sanjib Hussein, Mohd Zobir Tuberculosis (TB) is a bacterial disease responsible for millions of infections and preventable deaths each year. Its treatment is complicated by patients’ noncompliance due to dosing frequency, lengthy treatment, and adverse side effects associated with current chemotherapy. However, no modifications to the half-a-century old standard chemotherapy have been made based on a nanoformulation strategy to improve pharmacokinetic efficacy. In this study, we have designed a new nanodelivery formulation, using graphene oxide as the nanocarrier, loaded with the anti-TB antibiotic, ethambutol. The designed formulation was characterized using a number of molecular analytical techniques. It was found that sustained release of the drug resulted in better bioavailability. In addition, the designed formulation demonstrated high biocompatibility with mouse fibroblast cells. The anti-TB activity of the nanodelivery formulation was determined using whole-cell resazurin microtiter plate assay, modified-spot culture growth inhibition assay, and biofilm inhibition assay. The nanodelivery formulation showed good anti-mycobacterial activity. The anti-mycobacterial activity of Ethambutol was unaffected by the drug loading and release process. The results of this study demonstrated the potential of this new nanodelivery formulation strategy to be considered for modifying existing chemotherapy to yield more efficacious antibiotic treatment against TB. Multidisciplinary Digital Publishing Institute 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/62548/1/TB.pdf Bullo, Saifullah and Chrzastek, Alina and Maitra, Arundhati and Naeemullah, Bullo and Fakurazi, Sharida and Bhakta, Sanjib and Hussein, Mohd Zobir (2017) Novel anti-tuberculosis nanodelivery formulation of ethambutol with graphene oxide. Molecules, 22 (10). pp. 1-12. ISSN 1420-3049 https://www.mdpi.com/1420-3049/22/10/1560 10.3390/molecules22101560
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Tuberculosis (TB) is a bacterial disease responsible for millions of infections and preventable deaths each year. Its treatment is complicated by patients’ noncompliance due to dosing frequency, lengthy treatment, and adverse side effects associated with current chemotherapy. However, no modifications to the half-a-century old standard chemotherapy have been made based on a nanoformulation strategy to improve pharmacokinetic efficacy. In this study, we have designed a new nanodelivery formulation, using graphene oxide as the nanocarrier, loaded with the anti-TB antibiotic, ethambutol. The designed formulation was characterized using a number of molecular analytical techniques. It was found that sustained release of the drug resulted in better bioavailability. In addition, the designed formulation demonstrated high biocompatibility with mouse fibroblast cells. The anti-TB activity of the nanodelivery formulation was determined using whole-cell resazurin microtiter plate assay, modified-spot culture growth inhibition assay, and biofilm inhibition assay. The nanodelivery formulation showed good anti-mycobacterial activity. The anti-mycobacterial activity of Ethambutol was unaffected by the drug loading and release process. The results of this study demonstrated the potential of this new nanodelivery formulation strategy to be considered for modifying existing chemotherapy to yield more efficacious antibiotic treatment against TB.
format Article
author Bullo, Saifullah
Chrzastek, Alina
Maitra, Arundhati
Naeemullah, Bullo
Fakurazi, Sharida
Bhakta, Sanjib
Hussein, Mohd Zobir
spellingShingle Bullo, Saifullah
Chrzastek, Alina
Maitra, Arundhati
Naeemullah, Bullo
Fakurazi, Sharida
Bhakta, Sanjib
Hussein, Mohd Zobir
Novel anti-tuberculosis nanodelivery formulation of ethambutol with graphene oxide
author_facet Bullo, Saifullah
Chrzastek, Alina
Maitra, Arundhati
Naeemullah, Bullo
Fakurazi, Sharida
Bhakta, Sanjib
Hussein, Mohd Zobir
author_sort Bullo, Saifullah
title Novel anti-tuberculosis nanodelivery formulation of ethambutol with graphene oxide
title_short Novel anti-tuberculosis nanodelivery formulation of ethambutol with graphene oxide
title_full Novel anti-tuberculosis nanodelivery formulation of ethambutol with graphene oxide
title_fullStr Novel anti-tuberculosis nanodelivery formulation of ethambutol with graphene oxide
title_full_unstemmed Novel anti-tuberculosis nanodelivery formulation of ethambutol with graphene oxide
title_sort novel anti-tuberculosis nanodelivery formulation of ethambutol with graphene oxide
publisher Multidisciplinary Digital Publishing Institute
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/62548/1/TB.pdf
http://psasir.upm.edu.my/id/eprint/62548/
https://www.mdpi.com/1420-3049/22/10/1560
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score 13.211869

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