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Metabolomics study in methylotrophic yeast: a minireview

Methylotrophic yeast has been used as a cost-effective and valuable host for expression of recombinant protein due to its unique methanol utilisation pathway. It has an AOX (alcohol oxidase) protein which has been characterised to be a strong and tightly methanol-inducible dependent promoter. Metabo...

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Main Authors: Fam, Jye Ping, Sabri, Suriana, Baharum, Syarul Nataqain, Salleh, Abu Bakar, Oslan, Siti Nurbaya
Format: Article
Language:English
Published: Kamla-Raj Enterprises 2017
Online Access:http://psasir.upm.edu.my/id/eprint/62398/1/Metabolomics%20study%20in%20methylotrophic%20yeast.pdf
http://psasir.upm.edu.my/id/eprint/62398/
http://www.davidpublisher.org/index.php/Home/Article/index?id=31671.html
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spelling my.upm.eprints.623982020-01-10T06:19:56Z http://psasir.upm.edu.my/id/eprint/62398/ Metabolomics study in methylotrophic yeast: a minireview Fam, Jye Ping Sabri, Suriana Baharum, Syarul Nataqain Salleh, Abu Bakar Oslan, Siti Nurbaya Methylotrophic yeast has been used as a cost-effective and valuable host for expression of recombinant protein due to its unique methanol utilisation pathway. It has an AOX (alcohol oxidase) protein which has been characterised to be a strong and tightly methanol-inducible dependent promoter. Metabolomics is the systematic study and inclusive analysis of small molecules called metabolites in a biological system. Metabolomics plays an important part in connecting the phenotype and genotype gap because it magnifies the modifications in the proteome and provides a better phenotype representation of an organism. This quantitative study has provided a new perception on the metabolic burden derived from the overexpression of recombinant protein in methylotrophic yeast. In this review, we discuss the fundamental aspect of metabolomics in methylotrophic yeast followed by their latest developments. Kamla-Raj Enterprises 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/62398/1/Metabolomics%20study%20in%20methylotrophic%20yeast.pdf Fam, Jye Ping and Sabri, Suriana and Baharum, Syarul Nataqain and Salleh, Abu Bakar and Oslan, Siti Nurbaya (2017) Metabolomics study in methylotrophic yeast: a minireview. Journal of Life Sciences, 11. pp. 11-18. ISSN 1934-7391; ESSN: 1934-7405 http://www.davidpublisher.org/index.php/Home/Article/index?id=31671.html 10.17265/1934-7391/2017.01.002
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Methylotrophic yeast has been used as a cost-effective and valuable host for expression of recombinant protein due to its unique methanol utilisation pathway. It has an AOX (alcohol oxidase) protein which has been characterised to be a strong and tightly methanol-inducible dependent promoter. Metabolomics is the systematic study and inclusive analysis of small molecules called metabolites in a biological system. Metabolomics plays an important part in connecting the phenotype and genotype gap because it magnifies the modifications in the proteome and provides a better phenotype representation of an organism. This quantitative study has provided a new perception on the metabolic burden derived from the overexpression of recombinant protein in methylotrophic yeast. In this review, we discuss the fundamental aspect of metabolomics in methylotrophic yeast followed by their latest developments.
format Article
author Fam, Jye Ping
Sabri, Suriana
Baharum, Syarul Nataqain
Salleh, Abu Bakar
Oslan, Siti Nurbaya
spellingShingle Fam, Jye Ping
Sabri, Suriana
Baharum, Syarul Nataqain
Salleh, Abu Bakar
Oslan, Siti Nurbaya
Metabolomics study in methylotrophic yeast: a minireview
author_facet Fam, Jye Ping
Sabri, Suriana
Baharum, Syarul Nataqain
Salleh, Abu Bakar
Oslan, Siti Nurbaya
author_sort Fam, Jye Ping
title Metabolomics study in methylotrophic yeast: a minireview
title_short Metabolomics study in methylotrophic yeast: a minireview
title_full Metabolomics study in methylotrophic yeast: a minireview
title_fullStr Metabolomics study in methylotrophic yeast: a minireview
title_full_unstemmed Metabolomics study in methylotrophic yeast: a minireview
title_sort metabolomics study in methylotrophic yeast: a minireview
publisher Kamla-Raj Enterprises
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/62398/1/Metabolomics%20study%20in%20methylotrophic%20yeast.pdf
http://psasir.upm.edu.my/id/eprint/62398/
http://www.davidpublisher.org/index.php/Home/Article/index?id=31671.html
_version_ 1657489298488819712
score 13.211869

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