Mesenchymal stem cell-mediated T cell immunosuppression

Besides being a pool forstromal cells and connective tissues, the mesenchymal stem cells (MSCs) as well exert a potent immunosuppression against almost all types of immune cells, particularly T cells. Many in vitro and in vivo studies revealed that the reported regenerative property of MSCs is parti...

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Main Authors: Al-Graittee, Satar Jabbar Rahi, Lawal, Hamza, Ramasamy, Rajesh
Format: Article
Language:English
Published: Gavin Publishers 2017
Online Access:http://psasir.upm.edu.my/id/eprint/62394/1/Mesenchymal%20stem%20cell-mediated%20T%20cell%20immunosuppression.pdf
http://psasir.upm.edu.my/id/eprint/62394/
https://gavinpublishers.com/articles/research-article/Stem-Cell-Advanced-Research-and-Therapy/mesenchymal-stem-cell-mediated-t-cell-immunosuppression
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spelling my.upm.eprints.623942020-01-10T04:14:07Z http://psasir.upm.edu.my/id/eprint/62394/ Mesenchymal stem cell-mediated T cell immunosuppression Al-Graittee, Satar Jabbar Rahi Lawal, Hamza Ramasamy, Rajesh Besides being a pool forstromal cells and connective tissues, the mesenchymal stem cells (MSCs) as well exert a potent immunosuppression against almost all types of immune cells, particularly T cells. Many in vitro and in vivo studies revealed that the reported regenerative property of MSCs is partially due to the immunosuppressive activity of MSCs where it creates an optimal microenvironment for the execution of reparative and restorative processes. To date, MSCs caninteract with nearly all cells of the immune system, in a convoluted mechanism with theabilityof inhibiting the activation, proliferation, and function of T cells. These characteristicsshowcaseMSCs’ candidature as anaturalimmunosuppressive agent in regenerative medicine, therapies for immune disorders and tissue engineering. In this review, the intricate mechanisms of MSC-mediated immunosuppression on Tcellswere briefly evaluated. The physical, paracrine and molecular interactions that being toolsfor delivering the immunosuppressionwere also highlighted. Gavin Publishers 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/62394/1/Mesenchymal%20stem%20cell-mediated%20T%20cell%20immunosuppression.pdf Al-Graittee, Satar Jabbar Rahi and Lawal, Hamza and Ramasamy, Rajesh (2017) Mesenchymal stem cell-mediated T cell immunosuppression. Stem Cell: Advanced Research and Therapy, 2017 (3). pp. 1-5. ISSN 2637-9589 https://gavinpublishers.com/articles/research-article/Stem-Cell-Advanced-Research-and-Therapy/mesenchymal-stem-cell-mediated-t-cell-immunosuppression 10.29011/SCRT-119. 000019
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Besides being a pool forstromal cells and connective tissues, the mesenchymal stem cells (MSCs) as well exert a potent immunosuppression against almost all types of immune cells, particularly T cells. Many in vitro and in vivo studies revealed that the reported regenerative property of MSCs is partially due to the immunosuppressive activity of MSCs where it creates an optimal microenvironment for the execution of reparative and restorative processes. To date, MSCs caninteract with nearly all cells of the immune system, in a convoluted mechanism with theabilityof inhibiting the activation, proliferation, and function of T cells. These characteristicsshowcaseMSCs’ candidature as anaturalimmunosuppressive agent in regenerative medicine, therapies for immune disorders and tissue engineering. In this review, the intricate mechanisms of MSC-mediated immunosuppression on Tcellswere briefly evaluated. The physical, paracrine and molecular interactions that being toolsfor delivering the immunosuppressionwere also highlighted.
format Article
author Al-Graittee, Satar Jabbar Rahi
Lawal, Hamza
Ramasamy, Rajesh
spellingShingle Al-Graittee, Satar Jabbar Rahi
Lawal, Hamza
Ramasamy, Rajesh
Mesenchymal stem cell-mediated T cell immunosuppression
author_facet Al-Graittee, Satar Jabbar Rahi
Lawal, Hamza
Ramasamy, Rajesh
author_sort Al-Graittee, Satar Jabbar Rahi
title Mesenchymal stem cell-mediated T cell immunosuppression
title_short Mesenchymal stem cell-mediated T cell immunosuppression
title_full Mesenchymal stem cell-mediated T cell immunosuppression
title_fullStr Mesenchymal stem cell-mediated T cell immunosuppression
title_full_unstemmed Mesenchymal stem cell-mediated T cell immunosuppression
title_sort mesenchymal stem cell-mediated t cell immunosuppression
publisher Gavin Publishers
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/62394/1/Mesenchymal%20stem%20cell-mediated%20T%20cell%20immunosuppression.pdf
http://psasir.upm.edu.my/id/eprint/62394/
https://gavinpublishers.com/articles/research-article/Stem-Cell-Advanced-Research-and-Therapy/mesenchymal-stem-cell-mediated-t-cell-immunosuppression
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score 13.211869