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Immunohistochemical expression of NANOG in urothelial carcinoma of the bladder

Urothelial carcinoma is a common malignant neoplasm that has a poor prognosis and a high frequency of recurrence and metastasis. Constant disease surveillance with periodic and long term cystoscopy examination is necessary for management of the disease. However, the monitoring and therapy regimen is...

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Main Authors: Md Akhir, Mohd Khairul Anuar, Hussin, Huzlinda, Veerakumarasivam, Abhimanyu, Choy, Chan Soon, Abdullah, Maizaton Atmadini, Abdul Ghani, Fauzah
Format: Article
Language:English
Published: Malaysian Society of Pathologists 2017
Online Access:http://psasir.upm.edu.my/id/eprint/62086/1/Immunohistochemical%20expression%20of%20NANOG%20in%20urothelial%20carcinoma%20of%20the%20bladder.pdf
http://psasir.upm.edu.my/id/eprint/62086/
http://www.mjpath.org.my/2017/v39n3/index.php
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spelling my.upm.eprints.620862019-03-25T04:36:19Z http://psasir.upm.edu.my/id/eprint/62086/ Immunohistochemical expression of NANOG in urothelial carcinoma of the bladder Md Akhir, Mohd Khairul Anuar Hussin, Huzlinda Veerakumarasivam, Abhimanyu Choy, Chan Soon Abdullah, Maizaton Atmadini Abdul Ghani, Fauzah Urothelial carcinoma is a common malignant neoplasm that has a poor prognosis and a high frequency of recurrence and metastasis. Constant disease surveillance with periodic and long term cystoscopy examination is necessary for management of the disease. However, the monitoring and therapy regimen is expensive, incurring a massive burden to patients and the government. Therefore, the development of specific biomarkers for urothelial carcinoma at an early stage and recurrence detection becomes a priority. Homeobox genes are a family of genes that are involved in tumourigenesis. They might be potential prognostic markers for urothelial carcinoma. The study investigated the expression pattern of NANOG which is one of a homeobox gene in different stages and grades of urothelial carcinoma. NANOG expressions were also correlated with patient demographic factors and clinicopathological parameters. The expression of NANOG in 100 formalin-fixed paraffin-embedded urothelial carcinoma tissues was determined by immunohistochemistry. Immunohistochemistry showed positive expression of NANOG in all specimens with detection in the cytoplasm, nuclei and the nuclear membrane of the cancer cells. The immunohistochemical expression of NANOG increased across stages and grades of the tumour. The expression of NANOG was not significantly associated with demographic factors; gender (p = 0.376), race (p = 0.718) and age (p = 0.058) as well as with most of the clinicopathological parameters; pathological stage (p = 0.144), grade (p = 0.625), lymph node involvement (p = 0.174) and distant metastasis (p = 0.228). However, NANOG expression showed significant correlation with tumour invasion (p = 0.019). We concluded that NANOG might be a potential biomarker for early diagnosis of urothelial carcinoma of the bladder. Malaysian Society of Pathologists 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/62086/1/Immunohistochemical%20expression%20of%20NANOG%20in%20urothelial%20carcinoma%20of%20the%20bladder.pdf Md Akhir, Mohd Khairul Anuar and Hussin, Huzlinda and Veerakumarasivam, Abhimanyu and Choy, Chan Soon and Abdullah, Maizaton Atmadini and Abdul Ghani, Fauzah (2017) Immunohistochemical expression of NANOG in urothelial carcinoma of the bladder. The Malaysian Journal of Pathology, 39 (3). 227 - 234. ISSN 0126-8635 http://www.mjpath.org.my/2017/v39n3/index.php
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Urothelial carcinoma is a common malignant neoplasm that has a poor prognosis and a high frequency of recurrence and metastasis. Constant disease surveillance with periodic and long term cystoscopy examination is necessary for management of the disease. However, the monitoring and therapy regimen is expensive, incurring a massive burden to patients and the government. Therefore, the development of specific biomarkers for urothelial carcinoma at an early stage and recurrence detection becomes a priority. Homeobox genes are a family of genes that are involved in tumourigenesis. They might be potential prognostic markers for urothelial carcinoma. The study investigated the expression pattern of NANOG which is one of a homeobox gene in different stages and grades of urothelial carcinoma. NANOG expressions were also correlated with patient demographic factors and clinicopathological parameters. The expression of NANOG in 100 formalin-fixed paraffin-embedded urothelial carcinoma tissues was determined by immunohistochemistry. Immunohistochemistry showed positive expression of NANOG in all specimens with detection in the cytoplasm, nuclei and the nuclear membrane of the cancer cells. The immunohistochemical expression of NANOG increased across stages and grades of the tumour. The expression of NANOG was not significantly associated with demographic factors; gender (p = 0.376), race (p = 0.718) and age (p = 0.058) as well as with most of the clinicopathological parameters; pathological stage (p = 0.144), grade (p = 0.625), lymph node involvement (p = 0.174) and distant metastasis (p = 0.228). However, NANOG expression showed significant correlation with tumour invasion (p = 0.019). We concluded that NANOG might be a potential biomarker for early diagnosis of urothelial carcinoma of the bladder.
format Article
author Md Akhir, Mohd Khairul Anuar
Hussin, Huzlinda
Veerakumarasivam, Abhimanyu
Choy, Chan Soon
Abdullah, Maizaton Atmadini
Abdul Ghani, Fauzah
spellingShingle Md Akhir, Mohd Khairul Anuar
Hussin, Huzlinda
Veerakumarasivam, Abhimanyu
Choy, Chan Soon
Abdullah, Maizaton Atmadini
Abdul Ghani, Fauzah
Immunohistochemical expression of NANOG in urothelial carcinoma of the bladder
author_facet Md Akhir, Mohd Khairul Anuar
Hussin, Huzlinda
Veerakumarasivam, Abhimanyu
Choy, Chan Soon
Abdullah, Maizaton Atmadini
Abdul Ghani, Fauzah
author_sort Md Akhir, Mohd Khairul Anuar
title Immunohistochemical expression of NANOG in urothelial carcinoma of the bladder
title_short Immunohistochemical expression of NANOG in urothelial carcinoma of the bladder
title_full Immunohistochemical expression of NANOG in urothelial carcinoma of the bladder
title_fullStr Immunohistochemical expression of NANOG in urothelial carcinoma of the bladder
title_full_unstemmed Immunohistochemical expression of NANOG in urothelial carcinoma of the bladder
title_sort immunohistochemical expression of nanog in urothelial carcinoma of the bladder
publisher Malaysian Society of Pathologists
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/62086/1/Immunohistochemical%20expression%20of%20NANOG%20in%20urothelial%20carcinoma%20of%20the%20bladder.pdf
http://psasir.upm.edu.my/id/eprint/62086/
http://www.mjpath.org.my/2017/v39n3/index.php
_version_ 1643837667043966976
score 13.211869

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