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Flower-like copper sulfide nanocrystals are highly effective against chloroquine-resistant plasmodium falciparum and the malaria vector Anopheles stephensi

Anopheles stephensi is a mosquito of outstanding public health relevance, acting as a major vector of malaria in a number of tropical and subtropical areas worldwide. In recent years, important efforts have been conducted to propose nano-formulated larvicides as valuable alternatives to synthetic in...

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Main Authors: Theerthagiri, Jayaraman, Madhavan, Jagan, Murugan, Kadarkarai, Samidoss, Christina Mary, Kumar, Suresh, Higuchi, Akon, Benelli, Giovanni
Format: Article
Language:English
Published: Springer Link 2017
Online Access:http://psasir.upm.edu.my/id/eprint/61900/1/Flower-like%20copper%20sulfide%20nanocrystals%20.pdf
http://psasir.upm.edu.my/id/eprint/61900/
https://link.springer.com/article/10.1007/s10876-016-1128-2
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spelling my.upm.eprints.619002019-02-26T08:52:34Z http://psasir.upm.edu.my/id/eprint/61900/ Flower-like copper sulfide nanocrystals are highly effective against chloroquine-resistant plasmodium falciparum and the malaria vector Anopheles stephensi Theerthagiri, Jayaraman Madhavan, Jagan Murugan, Kadarkarai Samidoss, Christina Mary Kumar, Suresh Higuchi, Akon Benelli, Giovanni Anopheles stephensi is a mosquito of outstanding public health relevance, acting as a major vector of malaria in a number of tropical and subtropical areas worldwide. In recent years, important efforts have been conducted to propose nano-formulated larvicides as valuable alternatives to synthetic insecticides currently marketed. In the present study, the toxicity of flower-like copper sulfide (CuS) nanocrystals has been investigated on the malaria vector A. stephensi and Plasmodium parasites. Characterization of synthesized CuS nanocrystals was carried out using FTIR spectroscopy, XRD analysis, FESEM, HR-TEM and EDS. In mosquitocidal assays, LC50 values ranged from 23.347 ppm (first-instar larvae) to 48.789 ppm (pupae). In vitro anti-plasmodial activity of CuS nanoflowers was evaluated against chloroquine-resistant (CQ-r) and CQ-sensitive (CQ-s) strains of Plasmodium falciparum. IC50were 83.44 μg/mL (CQ-s) and 87.15 μg/mL (CQ-r). However, in vivo antiplasmodial experiments conducted on Plasmodium berghei infecting albino mice showed limited activity of CuS nanocrystals, if compared to CQ. Overall, our findings showed that chemically synthesized flower-like CuS nanocrystals are promising to improve the effectiveness of mosquito control programs, as well as to develop novel antiplasmodial drugs. Springer Link 2017-01 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/61900/1/Flower-like%20copper%20sulfide%20nanocrystals%20.pdf Theerthagiri, Jayaraman and Madhavan, Jagan and Murugan, Kadarkarai and Samidoss, Christina Mary and Kumar, Suresh and Higuchi, Akon and Benelli, Giovanni (2017) Flower-like copper sulfide nanocrystals are highly effective against chloroquine-resistant plasmodium falciparum and the malaria vector Anopheles stephensi. Journal of Cluster Science, 28 (1). 581 - 594. ISSN 1040-7278; ESSN: 1572-8862 https://link.springer.com/article/10.1007/s10876-016-1128-2 10.1007/s10876-016-1128-2
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Anopheles stephensi is a mosquito of outstanding public health relevance, acting as a major vector of malaria in a number of tropical and subtropical areas worldwide. In recent years, important efforts have been conducted to propose nano-formulated larvicides as valuable alternatives to synthetic insecticides currently marketed. In the present study, the toxicity of flower-like copper sulfide (CuS) nanocrystals has been investigated on the malaria vector A. stephensi and Plasmodium parasites. Characterization of synthesized CuS nanocrystals was carried out using FTIR spectroscopy, XRD analysis, FESEM, HR-TEM and EDS. In mosquitocidal assays, LC50 values ranged from 23.347 ppm (first-instar larvae) to 48.789 ppm (pupae). In vitro anti-plasmodial activity of CuS nanoflowers was evaluated against chloroquine-resistant (CQ-r) and CQ-sensitive (CQ-s) strains of Plasmodium falciparum. IC50were 83.44 μg/mL (CQ-s) and 87.15 μg/mL (CQ-r). However, in vivo antiplasmodial experiments conducted on Plasmodium berghei infecting albino mice showed limited activity of CuS nanocrystals, if compared to CQ. Overall, our findings showed that chemically synthesized flower-like CuS nanocrystals are promising to improve the effectiveness of mosquito control programs, as well as to develop novel antiplasmodial drugs.
format Article
author Theerthagiri, Jayaraman
Madhavan, Jagan
Murugan, Kadarkarai
Samidoss, Christina Mary
Kumar, Suresh
Higuchi, Akon
Benelli, Giovanni
spellingShingle Theerthagiri, Jayaraman
Madhavan, Jagan
Murugan, Kadarkarai
Samidoss, Christina Mary
Kumar, Suresh
Higuchi, Akon
Benelli, Giovanni
Flower-like copper sulfide nanocrystals are highly effective against chloroquine-resistant plasmodium falciparum and the malaria vector Anopheles stephensi
author_facet Theerthagiri, Jayaraman
Madhavan, Jagan
Murugan, Kadarkarai
Samidoss, Christina Mary
Kumar, Suresh
Higuchi, Akon
Benelli, Giovanni
author_sort Theerthagiri, Jayaraman
title Flower-like copper sulfide nanocrystals are highly effective against chloroquine-resistant plasmodium falciparum and the malaria vector Anopheles stephensi
title_short Flower-like copper sulfide nanocrystals are highly effective against chloroquine-resistant plasmodium falciparum and the malaria vector Anopheles stephensi
title_full Flower-like copper sulfide nanocrystals are highly effective against chloroquine-resistant plasmodium falciparum and the malaria vector Anopheles stephensi
title_fullStr Flower-like copper sulfide nanocrystals are highly effective against chloroquine-resistant plasmodium falciparum and the malaria vector Anopheles stephensi
title_full_unstemmed Flower-like copper sulfide nanocrystals are highly effective against chloroquine-resistant plasmodium falciparum and the malaria vector Anopheles stephensi
title_sort flower-like copper sulfide nanocrystals are highly effective against chloroquine-resistant plasmodium falciparum and the malaria vector anopheles stephensi
publisher Springer Link
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/61900/1/Flower-like%20copper%20sulfide%20nanocrystals%20.pdf
http://psasir.upm.edu.my/id/eprint/61900/
https://link.springer.com/article/10.1007/s10876-016-1128-2
_version_ 1643837620885651456
score 13.222552

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