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Evaluation of the neurotoxic effects of chronic embryonic exposure with inorganic mercury on motor and anxiety-like responses in zebrafish (Danio rerio) larvae

Chronic exposure to mercury (Hg) can lead to cumulative impairments in motor and cognitive functions including alteration in anxiety responses. Although several risk factors have been identified in recent year, little is known about the environmental factors that either due exposure toward low level...

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Main Authors: Abu Bakar, Noraini, Mohd Sata, Nurul Syafida Asma', Ramlan, Nurul Farhana, Wan Ibrahim, Wan Norhamidah, Zulkifli, Syaizwan Zahmir, Che Abdullah, Che Azurahanim, Ahmad, Syahida, Azmai, Mohammad Noor Amal
Format: Article
Language:English
Published: 2017
Online Access:http://psasir.upm.edu.my/id/eprint/61797/1/Evaluation%20of%20the%20neurotoxic%20effects%20of%20chronic%20embryonic%20exposure%20.pdf
http://psasir.upm.edu.my/id/eprint/61797/
https://www.sciencedirect.com/science/article/pii/S0892036216301532?via%3Dihub
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spelling my.upm.eprints.617972019-01-28T03:02:49Z http://psasir.upm.edu.my/id/eprint/61797/ Evaluation of the neurotoxic effects of chronic embryonic exposure with inorganic mercury on motor and anxiety-like responses in zebrafish (Danio rerio) larvae Abu Bakar, Noraini Mohd Sata, Nurul Syafida Asma' Ramlan, Nurul Farhana Wan Ibrahim, Wan Norhamidah Zulkifli, Syaizwan Zahmir Che Abdullah, Che Azurahanim Ahmad, Syahida Azmai, Mohammad Noor Amal Chronic exposure to mercury (Hg) can lead to cumulative impairments in motor and cognitive functions including alteration in anxiety responses. Although several risk factors have been identified in recent year, little is known about the environmental factors that either due exposure toward low level of inorganic mercury that may led to the developmental disorders. The present study investigated the effects of embryonic exposure of mercury chloride on motor function and anxiety-like behavior. The embryo exposed to 6 different concentrations of HgCl2 (7.5, 15, 30, 100, 125, 250 nM) at 5 hpf until hatching (72 hpf) in a semi-static condition. The mortality rate increased in a dose dependent manner where the chronic embryonic exposure to 100 nM decreased the number of tail coiling, heartbeat, and swimming activity. Aversive stimulus was used to examine the effects of 100 nM interferes with the development of anxiety-related behavior. No elevation in both thigmotaxis and avoidance response of 6 dpf larvae exposed with 100 nM were found. Biochemical analysis showed HgCl2 exposure affects proteins, lipids, carbohydrates and nucleic acids of the zebrafish larvae. These results showed that implication of HgCl2 on locomotor and biochemical defects affects motor performance and anxiety-like responses. Yet, the potential underlying mechanisms these responses need to be further investigated which is crucial to prevent potential hazards on the developing organism due to neurotoxicant exposure. 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/61797/1/Evaluation%20of%20the%20neurotoxic%20effects%20of%20chronic%20embryonic%20exposure%20.pdf Abu Bakar, Noraini and Mohd Sata, Nurul Syafida Asma' and Ramlan, Nurul Farhana and Wan Ibrahim, Wan Norhamidah and Zulkifli, Syaizwan Zahmir and Che Abdullah, Che Azurahanim and Ahmad, Syahida and Azmai, Mohammad Noor Amal (2017) Evaluation of the neurotoxic effects of chronic embryonic exposure with inorganic mercury on motor and anxiety-like responses in zebrafish (Danio rerio) larvae. Neurotoxicology and Teratology, 59. pp. 53-61. ISSN 0892-0362; ESSN: 1872-9738 https://www.sciencedirect.com/science/article/pii/S0892036216301532?via%3Dihub 10.1016/j.ntt.2016.11.008
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Chronic exposure to mercury (Hg) can lead to cumulative impairments in motor and cognitive functions including alteration in anxiety responses. Although several risk factors have been identified in recent year, little is known about the environmental factors that either due exposure toward low level of inorganic mercury that may led to the developmental disorders. The present study investigated the effects of embryonic exposure of mercury chloride on motor function and anxiety-like behavior. The embryo exposed to 6 different concentrations of HgCl2 (7.5, 15, 30, 100, 125, 250 nM) at 5 hpf until hatching (72 hpf) in a semi-static condition. The mortality rate increased in a dose dependent manner where the chronic embryonic exposure to 100 nM decreased the number of tail coiling, heartbeat, and swimming activity. Aversive stimulus was used to examine the effects of 100 nM interferes with the development of anxiety-related behavior. No elevation in both thigmotaxis and avoidance response of 6 dpf larvae exposed with 100 nM were found. Biochemical analysis showed HgCl2 exposure affects proteins, lipids, carbohydrates and nucleic acids of the zebrafish larvae. These results showed that implication of HgCl2 on locomotor and biochemical defects affects motor performance and anxiety-like responses. Yet, the potential underlying mechanisms these responses need to be further investigated which is crucial to prevent potential hazards on the developing organism due to neurotoxicant exposure.
format Article
author Abu Bakar, Noraini
Mohd Sata, Nurul Syafida Asma'
Ramlan, Nurul Farhana
Wan Ibrahim, Wan Norhamidah
Zulkifli, Syaizwan Zahmir
Che Abdullah, Che Azurahanim
Ahmad, Syahida
Azmai, Mohammad Noor Amal
spellingShingle Abu Bakar, Noraini
Mohd Sata, Nurul Syafida Asma'
Ramlan, Nurul Farhana
Wan Ibrahim, Wan Norhamidah
Zulkifli, Syaizwan Zahmir
Che Abdullah, Che Azurahanim
Ahmad, Syahida
Azmai, Mohammad Noor Amal
Evaluation of the neurotoxic effects of chronic embryonic exposure with inorganic mercury on motor and anxiety-like responses in zebrafish (Danio rerio) larvae
author_facet Abu Bakar, Noraini
Mohd Sata, Nurul Syafida Asma'
Ramlan, Nurul Farhana
Wan Ibrahim, Wan Norhamidah
Zulkifli, Syaizwan Zahmir
Che Abdullah, Che Azurahanim
Ahmad, Syahida
Azmai, Mohammad Noor Amal
author_sort Abu Bakar, Noraini
title Evaluation of the neurotoxic effects of chronic embryonic exposure with inorganic mercury on motor and anxiety-like responses in zebrafish (Danio rerio) larvae
title_short Evaluation of the neurotoxic effects of chronic embryonic exposure with inorganic mercury on motor and anxiety-like responses in zebrafish (Danio rerio) larvae
title_full Evaluation of the neurotoxic effects of chronic embryonic exposure with inorganic mercury on motor and anxiety-like responses in zebrafish (Danio rerio) larvae
title_fullStr Evaluation of the neurotoxic effects of chronic embryonic exposure with inorganic mercury on motor and anxiety-like responses in zebrafish (Danio rerio) larvae
title_full_unstemmed Evaluation of the neurotoxic effects of chronic embryonic exposure with inorganic mercury on motor and anxiety-like responses in zebrafish (Danio rerio) larvae
title_sort evaluation of the neurotoxic effects of chronic embryonic exposure with inorganic mercury on motor and anxiety-like responses in zebrafish (danio rerio) larvae
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/61797/1/Evaluation%20of%20the%20neurotoxic%20effects%20of%20chronic%20embryonic%20exposure%20.pdf
http://psasir.upm.edu.my/id/eprint/61797/
https://www.sciencedirect.com/science/article/pii/S0892036216301532?via%3Dihub
_version_ 1643837597743579136
score 13.211869

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