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Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules

Considering the health benefits of tocotrienols, continuous works have been done on the encapsulation and delivery of these compounds. In this study, we encapsulated tocotrienols in chitosan-alginate microcapsules and evaluated their release profile. Generally, these tocotrienols microcapsules (TM)...

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Main Authors: Tan, Phui Yee, Tan, Tai Boon, Chang, Hon Weng, Tey, Beng Ti, Chan, Eng Seng, Lai, Oi Ming, Baharin, Badlishah Sham, Nehdi, Imededdine Arbi, Tan, Chin Ping
Format: Article
Language:English
Published: American Chemical Society 2017
Online Access:http://psasir.upm.edu.my/id/eprint/61648/1/Effects%20of%20environmental%20stresses%20and%20in%20vitro%20digestion%20.pdf
http://psasir.upm.edu.my/id/eprint/61648/
https://pubs.acs.org/doi/abs/10.1021/acs.jafc.7b03521
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spelling my.upm.eprints.616482018-10-24T08:11:40Z http://psasir.upm.edu.my/id/eprint/61648/ Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules Tan, Phui Yee Tan, Tai Boon Chang, Hon Weng Tey, Beng Ti Chan, Eng Seng Lai, Oi Ming Baharin, Badlishah Sham Nehdi, Imededdine Arbi Tan, Chin Ping Considering the health benefits of tocotrienols, continuous works have been done on the encapsulation and delivery of these compounds. In this study, we encapsulated tocotrienols in chitosan-alginate microcapsules and evaluated their release profile. Generally, these tocotrienols microcapsules (TM) displayed high thermal stability. When subjected to pH adjustments (pH 1–9), we observed that the release of tocotrienols was the highest (33.78 ± 0.18%) under basic conditions. The TM were also unstable against the effect of ionic strength, with a high release (70.73 ± 0.04%) of tocotrienols even at a low sodium chloride concentration (50 mM). As for the individual isomers, δ-tocotrienol was the most sensitive to pH and ionic strength. In contrast, β-/γ-tocotrienols were the most ionic-stable isomers but more responsive toward thermal treatment. Simulated gastrointestinal model showed that the chitosan-alginate-based TM could be used to retain tocotrienols in the gastric and subsequently release them in the intestines for possible absorption. American Chemical Society 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/61648/1/Effects%20of%20environmental%20stresses%20and%20in%20vitro%20digestion%20.pdf Tan, Phui Yee and Tan, Tai Boon and Chang, Hon Weng and Tey, Beng Ti and Chan, Eng Seng and Lai, Oi Ming and Baharin, Badlishah Sham and Nehdi, Imededdine Arbi and Tan, Chin Ping (2017) Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules. Journal of Agricultural and Food Chemistry, 65 (48). 10651 - 10657. ISSN 0021-8561 https://pubs.acs.org/doi/abs/10.1021/acs.jafc.7b03521 10.1021/acs.jafc.7b03521
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Considering the health benefits of tocotrienols, continuous works have been done on the encapsulation and delivery of these compounds. In this study, we encapsulated tocotrienols in chitosan-alginate microcapsules and evaluated their release profile. Generally, these tocotrienols microcapsules (TM) displayed high thermal stability. When subjected to pH adjustments (pH 1–9), we observed that the release of tocotrienols was the highest (33.78 ± 0.18%) under basic conditions. The TM were also unstable against the effect of ionic strength, with a high release (70.73 ± 0.04%) of tocotrienols even at a low sodium chloride concentration (50 mM). As for the individual isomers, δ-tocotrienol was the most sensitive to pH and ionic strength. In contrast, β-/γ-tocotrienols were the most ionic-stable isomers but more responsive toward thermal treatment. Simulated gastrointestinal model showed that the chitosan-alginate-based TM could be used to retain tocotrienols in the gastric and subsequently release them in the intestines for possible absorption.
format Article
author Tan, Phui Yee
Tan, Tai Boon
Chang, Hon Weng
Tey, Beng Ti
Chan, Eng Seng
Lai, Oi Ming
Baharin, Badlishah Sham
Nehdi, Imededdine Arbi
Tan, Chin Ping
spellingShingle Tan, Phui Yee
Tan, Tai Boon
Chang, Hon Weng
Tey, Beng Ti
Chan, Eng Seng
Lai, Oi Ming
Baharin, Badlishah Sham
Nehdi, Imededdine Arbi
Tan, Chin Ping
Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules
author_facet Tan, Phui Yee
Tan, Tai Boon
Chang, Hon Weng
Tey, Beng Ti
Chan, Eng Seng
Lai, Oi Ming
Baharin, Badlishah Sham
Nehdi, Imededdine Arbi
Tan, Chin Ping
author_sort Tan, Phui Yee
title Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules
title_short Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules
title_full Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules
title_fullStr Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules
title_full_unstemmed Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules
title_sort effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules
publisher American Chemical Society
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/61648/1/Effects%20of%20environmental%20stresses%20and%20in%20vitro%20digestion%20.pdf
http://psasir.upm.edu.my/id/eprint/61648/
https://pubs.acs.org/doi/abs/10.1021/acs.jafc.7b03521
_version_ 1643837564695609344
score 13.211869

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