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Chemical constituents and toxicity screening of three aromatic plant species from Peninsular Malaysia

Medicinal and aromatic plants (MAPs) are widely valued for their aromas, tastes, and treatments for various human illnesses. The chemical constituents and toxicity content of three aromatic plant species, Syzygium polyanthum Wight (Walp.), Monocarpia marginalis (Scheff.) J. Sinclair, and Chromolaena...

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Main Authors: Jumaat, Siti Rahimah, Tajuddin, Saiful Nizam, Sudmoon, Runglawan, Chaveerach, Arunrat, Abdullah, Ummi Hani, Mohamed, Rozi
Format: Article
Language:English
Published: North Carolina State University 2017
Online Access:http://psasir.upm.edu.my/id/eprint/61105/1/Chemical%20constituents%20and%20toxicity%20screening%20of%20three%20aromatic%20plant%20species%20from%20Peninsular%20Malaysia.pdf
http://psasir.upm.edu.my/id/eprint/61105/
http://ojs.cnr.ncsu.edu/index.php/BioRes/article/view/BioRes_12_3_5878_Jumaat_Chemical_Constituents_Toxicity_Screening
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spelling my.upm.eprints.611052018-09-20T09:15:17Z http://psasir.upm.edu.my/id/eprint/61105/ Chemical constituents and toxicity screening of three aromatic plant species from Peninsular Malaysia Jumaat, Siti Rahimah Tajuddin, Saiful Nizam Sudmoon, Runglawan Chaveerach, Arunrat Abdullah, Ummi Hani Mohamed, Rozi Medicinal and aromatic plants (MAPs) are widely valued for their aromas, tastes, and treatments for various human illnesses. The chemical constituents and toxicity content of three aromatic plant species, Syzygium polyanthum Wight (Walp.), Monocarpia marginalis (Scheff.) J. Sinclair, and Chromolaena odorata (L.) R.M. King & H. Rob, were determined, via gas chromatography (GC) with mass spectrometry (MS), and flame ionization detector (FID). Altogether, 116 compounds were identified in the essential oils and hexane and methanol extracts. Toxicity evaluations were carried out on human peripheral blood mononuclear cells (PBMCs). Three plant samples were found toxic to human PBMCs. The essential oils of M. marginalis and C. odorata, and the hexane extract of C. odorata yielded IC50 and LD50 values of 76 mg/mL and 6,913 mg/kg, 14 mg/mL and 3,684 mg/kg, and 2.45 mg/mL and 1,927 mg/kg, respectively. Based on the LD50 values, M. marginalis and C. odorata can be classified as slightly and moderately hazardous, respectively. A detailed toxicity evaluation via comet assay showed that M. marginalis and C. odorata induced significant DNA damage (p < 0.05). As for S. polyanthum, the species did not give any cytotoxic or genotoxic evidences. North Carolina State University 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/61105/1/Chemical%20constituents%20and%20toxicity%20screening%20of%20three%20aromatic%20plant%20species%20from%20Peninsular%20Malaysia.pdf Jumaat, Siti Rahimah and Tajuddin, Saiful Nizam and Sudmoon, Runglawan and Chaveerach, Arunrat and Abdullah, Ummi Hani and Mohamed, Rozi (2017) Chemical constituents and toxicity screening of three aromatic plant species from Peninsular Malaysia. BioResources, 12 (3). pp. 5878-5896. ISSN 1930-2126 http://ojs.cnr.ncsu.edu/index.php/BioRes/article/view/BioRes_12_3_5878_Jumaat_Chemical_Constituents_Toxicity_Screening
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Medicinal and aromatic plants (MAPs) are widely valued for their aromas, tastes, and treatments for various human illnesses. The chemical constituents and toxicity content of three aromatic plant species, Syzygium polyanthum Wight (Walp.), Monocarpia marginalis (Scheff.) J. Sinclair, and Chromolaena odorata (L.) R.M. King & H. Rob, were determined, via gas chromatography (GC) with mass spectrometry (MS), and flame ionization detector (FID). Altogether, 116 compounds were identified in the essential oils and hexane and methanol extracts. Toxicity evaluations were carried out on human peripheral blood mononuclear cells (PBMCs). Three plant samples were found toxic to human PBMCs. The essential oils of M. marginalis and C. odorata, and the hexane extract of C. odorata yielded IC50 and LD50 values of 76 mg/mL and 6,913 mg/kg, 14 mg/mL and 3,684 mg/kg, and 2.45 mg/mL and 1,927 mg/kg, respectively. Based on the LD50 values, M. marginalis and C. odorata can be classified as slightly and moderately hazardous, respectively. A detailed toxicity evaluation via comet assay showed that M. marginalis and C. odorata induced significant DNA damage (p < 0.05). As for S. polyanthum, the species did not give any cytotoxic or genotoxic evidences.
format Article
author Jumaat, Siti Rahimah
Tajuddin, Saiful Nizam
Sudmoon, Runglawan
Chaveerach, Arunrat
Abdullah, Ummi Hani
Mohamed, Rozi
spellingShingle Jumaat, Siti Rahimah
Tajuddin, Saiful Nizam
Sudmoon, Runglawan
Chaveerach, Arunrat
Abdullah, Ummi Hani
Mohamed, Rozi
Chemical constituents and toxicity screening of three aromatic plant species from Peninsular Malaysia
author_facet Jumaat, Siti Rahimah
Tajuddin, Saiful Nizam
Sudmoon, Runglawan
Chaveerach, Arunrat
Abdullah, Ummi Hani
Mohamed, Rozi
author_sort Jumaat, Siti Rahimah
title Chemical constituents and toxicity screening of three aromatic plant species from Peninsular Malaysia
title_short Chemical constituents and toxicity screening of three aromatic plant species from Peninsular Malaysia
title_full Chemical constituents and toxicity screening of three aromatic plant species from Peninsular Malaysia
title_fullStr Chemical constituents and toxicity screening of three aromatic plant species from Peninsular Malaysia
title_full_unstemmed Chemical constituents and toxicity screening of three aromatic plant species from Peninsular Malaysia
title_sort chemical constituents and toxicity screening of three aromatic plant species from peninsular malaysia
publisher North Carolina State University
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/61105/1/Chemical%20constituents%20and%20toxicity%20screening%20of%20three%20aromatic%20plant%20species%20from%20Peninsular%20Malaysia.pdf
http://psasir.upm.edu.my/id/eprint/61105/
http://ojs.cnr.ncsu.edu/index.php/BioRes/article/view/BioRes_12_3_5878_Jumaat_Chemical_Constituents_Toxicity_Screening
_version_ 1643837507442311168
score 13.211869

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