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Characterisation of sol-gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro

In this study, nanocrystalline magnesium zinc ferrite nanoparticles were successfully prepared by a simple sol-gel method using copper nitrate and ferric nitrate as raw materials. The calcined samples were characterised by differential thermal analysis/thermogravimetric analysis, Fourier transform i...

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Main Authors: Nordin, Noraini, Kanagesan, Samikannu, Zamberi, Nur Rizi, Yeap, Swee Keong, Abu, Nadiah, Tamilselvan, Subramani, Hashim, Mansor, Mohammed Alitheen, Noorjahan Banu
Format: Article
Language:English
Published: The Institution of Engineering and Technology 2017
Online Access:http://psasir.upm.edu.my/id/eprint/61081/1/Characterisation%20of%20sol-gel%20method%20synthesised%20MgZnFe2O4%20nanoparticles%20and%20its%20cytotoxic%20effects%20on%20breast%20cancer%20cell%20line%2C%20MDA%20MB-231%20in%20vitro.pdf
http://psasir.upm.edu.my/id/eprint/61081/
https://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=7891249
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spelling my.upm.eprints.610812019-05-06T08:21:06Z http://psasir.upm.edu.my/id/eprint/61081/ Characterisation of sol-gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro Nordin, Noraini Kanagesan, Samikannu Zamberi, Nur Rizi Yeap, Swee Keong Abu, Nadiah Tamilselvan, Subramani Hashim, Mansor Mohammed Alitheen, Noorjahan Banu In this study, nanocrystalline magnesium zinc ferrite nanoparticles were successfully prepared by a simple sol-gel method using copper nitrate and ferric nitrate as raw materials. The calcined samples were characterised by differential thermal analysis/thermogravimetric analysis, Fourier transform infrared spectroscopy and X-ray diffraction. Transmission electron microscopy revealed that the average particle size of the calcined sample was in a range of 17-41 nm with an average of 29 nm and has spherical size. A cytotoxicity test was performed on human breast cancer cells (MDA MB-231) and (MCF-7) at various concentrations starting from (0 µg/ml) to (800 µg/ml). The sample possessed a mild toxic effect toward MDA MB-231 and MCF-7 after being examined with MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5 diphenyltetrazolium bromide) assay for up to 72 h of incubation. Higher reduction of cells viability was observed as the concentration of sample was increased in MDA MB-231 cell line than in MCF-7. Therefore, further cytotoxicity tests were performed on MDA MB-231 cell line. The Institution of Engineering and Technology 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/61081/1/Characterisation%20of%20sol-gel%20method%20synthesised%20MgZnFe2O4%20nanoparticles%20and%20its%20cytotoxic%20effects%20on%20breast%20cancer%20cell%20line%2C%20MDA%20MB-231%20in%20vitro.pdf Nordin, Noraini and Kanagesan, Samikannu and Zamberi, Nur Rizi and Yeap, Swee Keong and Abu, Nadiah and Tamilselvan, Subramani and Hashim, Mansor and Mohammed Alitheen, Noorjahan Banu (2017) Characterisation of sol-gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro. IET Nanobiotechnology, 11 (3). 343 - 348. ISSN 1751-8741; ESSN: 1751-875X https://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=7891249 10.1049/iet-nbt.2016.0007
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description In this study, nanocrystalline magnesium zinc ferrite nanoparticles were successfully prepared by a simple sol-gel method using copper nitrate and ferric nitrate as raw materials. The calcined samples were characterised by differential thermal analysis/thermogravimetric analysis, Fourier transform infrared spectroscopy and X-ray diffraction. Transmission electron microscopy revealed that the average particle size of the calcined sample was in a range of 17-41 nm with an average of 29 nm and has spherical size. A cytotoxicity test was performed on human breast cancer cells (MDA MB-231) and (MCF-7) at various concentrations starting from (0 µg/ml) to (800 µg/ml). The sample possessed a mild toxic effect toward MDA MB-231 and MCF-7 after being examined with MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5 diphenyltetrazolium bromide) assay for up to 72 h of incubation. Higher reduction of cells viability was observed as the concentration of sample was increased in MDA MB-231 cell line than in MCF-7. Therefore, further cytotoxicity tests were performed on MDA MB-231 cell line.
format Article
author Nordin, Noraini
Kanagesan, Samikannu
Zamberi, Nur Rizi
Yeap, Swee Keong
Abu, Nadiah
Tamilselvan, Subramani
Hashim, Mansor
Mohammed Alitheen, Noorjahan Banu
spellingShingle Nordin, Noraini
Kanagesan, Samikannu
Zamberi, Nur Rizi
Yeap, Swee Keong
Abu, Nadiah
Tamilselvan, Subramani
Hashim, Mansor
Mohammed Alitheen, Noorjahan Banu
Characterisation of sol-gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro
author_facet Nordin, Noraini
Kanagesan, Samikannu
Zamberi, Nur Rizi
Yeap, Swee Keong
Abu, Nadiah
Tamilselvan, Subramani
Hashim, Mansor
Mohammed Alitheen, Noorjahan Banu
author_sort Nordin, Noraini
title Characterisation of sol-gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro
title_short Characterisation of sol-gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro
title_full Characterisation of sol-gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro
title_fullStr Characterisation of sol-gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro
title_full_unstemmed Characterisation of sol-gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro
title_sort characterisation of sol-gel method synthesised mgznfe2o4 nanoparticles and its cytotoxic effects on breast cancer cell line, mda mb-231 in vitro
publisher The Institution of Engineering and Technology
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/61081/1/Characterisation%20of%20sol-gel%20method%20synthesised%20MgZnFe2O4%20nanoparticles%20and%20its%20cytotoxic%20effects%20on%20breast%20cancer%20cell%20line%2C%20MDA%20MB-231%20in%20vitro.pdf
http://psasir.upm.edu.my/id/eprint/61081/
https://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=7891249
_version_ 1643837501180215296
score 13.211869

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