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Biochemical effects of statins on lipid parameters among newly diagnosed dyslipidaemia subjects in primary care

Introduction: Statins have several pleiotropic effects including its primary effect of lipid lowering that is important to prevent cardiovascular disease (CVD). Subjects often have heterogeneous responses to statin. This study aims to determine the biochemical effects of statins on lipid parameters...

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Main Authors: Meor Anuar Shuhaili, Meor Fairuz Rizal, Samsudin, Intan Nureslyna, Chew, Boon How, Abdul Rahman, Hejar, Stanslas, Johnson, Sumon, Md. Shariful Hasan, Ahmad, Zalinah, Chellappah Thambiah, Subashini
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Language:English
Published: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2018
Online Access:http://psasir.upm.edu.my/id/eprint/59692/1/2018031608372202_MJMHS_Vol14_No1_Jan2018_0057_-_4th_proof.pdf
http://psasir.upm.edu.my/id/eprint/59692/
http://www.medic.upm.edu.my/upload/dokumen/2018031608372202_MJMHS_Vol14_No1_Jan2018_0057_-_4th_proof.pdf
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spelling my.upm.eprints.596922018-03-19T03:04:40Z http://psasir.upm.edu.my/id/eprint/59692/ Biochemical effects of statins on lipid parameters among newly diagnosed dyslipidaemia subjects in primary care Meor Anuar Shuhaili, Meor Fairuz Rizal Samsudin, Intan Nureslyna Chew, Boon How Abdul Rahman, Hejar Stanslas, Johnson Sumon, Md. Shariful Hasan Ahmad, Zalinah Chellappah Thambiah, Subashini Introduction: Statins have several pleiotropic effects including its primary effect of lipid lowering that is important to prevent cardiovascular disease (CVD). Subjects often have heterogeneous responses to statin. This study aims to determine the biochemical effects of statins on lipid parameters among newly diagnosed dyslipidaemia subjects. Methods: This was a prospective observational study involving 118 newly diagnosed adults with dyslipidaemia from three government health clinics in Selangor, Malaysia. Biochemical analyses including fasting lipid profile [triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C)] and apolipoproteins (apoA1, apoB) were taken at baseline and follow-up after a month on statin. Results: Majority of subjects (61.9%) were prescribed with lovastatin, with the rest on simvastatin. At baseline, the median values for all lipid profile parameters (TC, LDL-C, HDL-C) and non-conventional lipid parameters (LDL-C:HDL-C ratio, non-HDL-C, TC:HDL-C ratio, apoB:apoA1 ratio) were deranged except for TG and apoA1. On follow up, all parameters showed median values within the reference range except for HDL-C, non-HDL-C and TC:HDL-C ratio. There was significant difference in the effect of statins on lipid parameters including predictors of cardiovascular risk, simvastatin having better effects. Conclusions: Different statins have varying effects on lipid parameters. Simvastatin showed significantly better effects compared to lovastatin. Non-HDL value should be included in the standard lipid profile report given its ease of use and implementation as it’s both a marker of coronary artery disease (CAD) risk stratification as well as an established determinant of goal attainment during therapy. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/59692/1/2018031608372202_MJMHS_Vol14_No1_Jan2018_0057_-_4th_proof.pdf Meor Anuar Shuhaili, Meor Fairuz Rizal and Samsudin, Intan Nureslyna and Chew, Boon How and Abdul Rahman, Hejar and Stanslas, Johnson and Sumon, Md. Shariful Hasan and Ahmad, Zalinah and Chellappah Thambiah, Subashini (2018) Biochemical effects of statins on lipid parameters among newly diagnosed dyslipidaemia subjects in primary care. Malaysian Journal of Medicine and Health Sciences, 14 (1). pp. 7-14. ISSN 1675-8544 http://www.medic.upm.edu.my/upload/dokumen/2018031608372202_MJMHS_Vol14_No1_Jan2018_0057_-_4th_proof.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Introduction: Statins have several pleiotropic effects including its primary effect of lipid lowering that is important to prevent cardiovascular disease (CVD). Subjects often have heterogeneous responses to statin. This study aims to determine the biochemical effects of statins on lipid parameters among newly diagnosed dyslipidaemia subjects. Methods: This was a prospective observational study involving 118 newly diagnosed adults with dyslipidaemia from three government health clinics in Selangor, Malaysia. Biochemical analyses including fasting lipid profile [triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C)] and apolipoproteins (apoA1, apoB) were taken at baseline and follow-up after a month on statin. Results: Majority of subjects (61.9%) were prescribed with lovastatin, with the rest on simvastatin. At baseline, the median values for all lipid profile parameters (TC, LDL-C, HDL-C) and non-conventional lipid parameters (LDL-C:HDL-C ratio, non-HDL-C, TC:HDL-C ratio, apoB:apoA1 ratio) were deranged except for TG and apoA1. On follow up, all parameters showed median values within the reference range except for HDL-C, non-HDL-C and TC:HDL-C ratio. There was significant difference in the effect of statins on lipid parameters including predictors of cardiovascular risk, simvastatin having better effects. Conclusions: Different statins have varying effects on lipid parameters. Simvastatin showed significantly better effects compared to lovastatin. Non-HDL value should be included in the standard lipid profile report given its ease of use and implementation as it’s both a marker of coronary artery disease (CAD) risk stratification as well as an established determinant of goal attainment during therapy.
format Article
author Meor Anuar Shuhaili, Meor Fairuz Rizal
Samsudin, Intan Nureslyna
Chew, Boon How
Abdul Rahman, Hejar
Stanslas, Johnson
Sumon, Md. Shariful Hasan
Ahmad, Zalinah
Chellappah Thambiah, Subashini
spellingShingle Meor Anuar Shuhaili, Meor Fairuz Rizal
Samsudin, Intan Nureslyna
Chew, Boon How
Abdul Rahman, Hejar
Stanslas, Johnson
Sumon, Md. Shariful Hasan
Ahmad, Zalinah
Chellappah Thambiah, Subashini
Biochemical effects of statins on lipid parameters among newly diagnosed dyslipidaemia subjects in primary care
author_facet Meor Anuar Shuhaili, Meor Fairuz Rizal
Samsudin, Intan Nureslyna
Chew, Boon How
Abdul Rahman, Hejar
Stanslas, Johnson
Sumon, Md. Shariful Hasan
Ahmad, Zalinah
Chellappah Thambiah, Subashini
author_sort Meor Anuar Shuhaili, Meor Fairuz Rizal
title Biochemical effects of statins on lipid parameters among newly diagnosed dyslipidaemia subjects in primary care
title_short Biochemical effects of statins on lipid parameters among newly diagnosed dyslipidaemia subjects in primary care
title_full Biochemical effects of statins on lipid parameters among newly diagnosed dyslipidaemia subjects in primary care
title_fullStr Biochemical effects of statins on lipid parameters among newly diagnosed dyslipidaemia subjects in primary care
title_full_unstemmed Biochemical effects of statins on lipid parameters among newly diagnosed dyslipidaemia subjects in primary care
title_sort biochemical effects of statins on lipid parameters among newly diagnosed dyslipidaemia subjects in primary care
publisher Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/59692/1/2018031608372202_MJMHS_Vol14_No1_Jan2018_0057_-_4th_proof.pdf
http://psasir.upm.edu.my/id/eprint/59692/
http://www.medic.upm.edu.my/upload/dokumen/2018031608372202_MJMHS_Vol14_No1_Jan2018_0057_-_4th_proof.pdf
_version_ 1643837146213122048
score 13.211869

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