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Evaluation of in vitro wound healing efficacy of breadfruit derived starch hydrolysate

To study the wound healing efficacy of breadfruit starch hydrolysate, an in vitro wound scratch assay was conducted, in which the migration rate of wounded NIH 3T3 fibroblasts was determined. Wounds treated with lower dextrose equivalent (DE), (DE 10-14) starch hydrolysate were found capable to impr...

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Main Authors: Mohamed Amin, Zahiah, Koh, Soo Peng, Tan, Chin Ping, Yeap, Swee Keong, Abdul Hamid, Nur Syazwani, Long, Kamariah
Format: Article
Language:English
Published: Faculty of Food Science and Technology, Universiti Putra Malaysia 2017
Online Access:http://psasir.upm.edu.my/id/eprint/58367/1/%2855%29.pdf
http://psasir.upm.edu.my/id/eprint/58367/
http://www.ifrj.upm.edu.my/24%20(04)%202017/(55).pdf
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spelling my.upm.eprints.583672018-01-12T08:17:15Z http://psasir.upm.edu.my/id/eprint/58367/ Evaluation of in vitro wound healing efficacy of breadfruit derived starch hydrolysate Mohamed Amin, Zahiah Koh, Soo Peng Tan, Chin Ping Yeap, Swee Keong Abdul Hamid, Nur Syazwani Long, Kamariah To study the wound healing efficacy of breadfruit starch hydrolysate, an in vitro wound scratch assay was conducted, in which the migration rate of wounded NIH 3T3 fibroblasts was determined. Wounds treated with lower dextrose equivalent (DE), (DE 10-14) starch hydrolysate were found capable to improve the wound healing of NIH 3T3 fibroblast cell with the percentage of wound closure improvement of 77%, respectively when compared with higher DE range (DE 15-19 and DE 20-24). The findings obtained in the BrdU uptake and MTT viability assays confirmed the wound healing properties of breadfruit starch hydrolysate as the starch hydrolysate-treated wounded NIH 3T3 fibroblasts were able to proliferate well and no cytotoxicity was observed. Together, these findings indicated that the newly developed breadfruit starch hydrolysate performed better than commercial (COM) starch hydrolysate of the same DE ranges. In conclusion, breadfruit starch hydrolysate had better functional properties than did starch hydrolysates derived from other sources and that they could play a beneficial role in wound healing applications. Faculty of Food Science and Technology, Universiti Putra Malaysia 2017 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/58367/1/%2855%29.pdf Mohamed Amin, Zahiah and Koh, Soo Peng and Tan, Chin Ping and Yeap, Swee Keong and Abdul Hamid, Nur Syazwani and Long, Kamariah (2017) Evaluation of in vitro wound healing efficacy of breadfruit derived starch hydrolysate. International Food Research Journal, 24 (4). pp. 1771-1781. ISSN 1985-4668; ESSN: 2231-7546 http://www.ifrj.upm.edu.my/24%20(04)%202017/(55).pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description To study the wound healing efficacy of breadfruit starch hydrolysate, an in vitro wound scratch assay was conducted, in which the migration rate of wounded NIH 3T3 fibroblasts was determined. Wounds treated with lower dextrose equivalent (DE), (DE 10-14) starch hydrolysate were found capable to improve the wound healing of NIH 3T3 fibroblast cell with the percentage of wound closure improvement of 77%, respectively when compared with higher DE range (DE 15-19 and DE 20-24). The findings obtained in the BrdU uptake and MTT viability assays confirmed the wound healing properties of breadfruit starch hydrolysate as the starch hydrolysate-treated wounded NIH 3T3 fibroblasts were able to proliferate well and no cytotoxicity was observed. Together, these findings indicated that the newly developed breadfruit starch hydrolysate performed better than commercial (COM) starch hydrolysate of the same DE ranges. In conclusion, breadfruit starch hydrolysate had better functional properties than did starch hydrolysates derived from other sources and that they could play a beneficial role in wound healing applications.
format Article
author Mohamed Amin, Zahiah
Koh, Soo Peng
Tan, Chin Ping
Yeap, Swee Keong
Abdul Hamid, Nur Syazwani
Long, Kamariah
spellingShingle Mohamed Amin, Zahiah
Koh, Soo Peng
Tan, Chin Ping
Yeap, Swee Keong
Abdul Hamid, Nur Syazwani
Long, Kamariah
Evaluation of in vitro wound healing efficacy of breadfruit derived starch hydrolysate
author_facet Mohamed Amin, Zahiah
Koh, Soo Peng
Tan, Chin Ping
Yeap, Swee Keong
Abdul Hamid, Nur Syazwani
Long, Kamariah
author_sort Mohamed Amin, Zahiah
title Evaluation of in vitro wound healing efficacy of breadfruit derived starch hydrolysate
title_short Evaluation of in vitro wound healing efficacy of breadfruit derived starch hydrolysate
title_full Evaluation of in vitro wound healing efficacy of breadfruit derived starch hydrolysate
title_fullStr Evaluation of in vitro wound healing efficacy of breadfruit derived starch hydrolysate
title_full_unstemmed Evaluation of in vitro wound healing efficacy of breadfruit derived starch hydrolysate
title_sort evaluation of in vitro wound healing efficacy of breadfruit derived starch hydrolysate
publisher Faculty of Food Science and Technology, Universiti Putra Malaysia
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/58367/1/%2855%29.pdf
http://psasir.upm.edu.my/id/eprint/58367/
http://www.ifrj.upm.edu.my/24%20(04)%202017/(55).pdf
_version_ 1643836762741538816
score 13.211869

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